The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: Implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer

2008 ◽  
Vol 26 (1) ◽  
pp. 110
Author(s):  
Yingming Li ◽  
Kenneth S. Koeneman
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Binding Protein ◽  
Ras Pathway ◽  
Finger Protein ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis

2011 ◽  
Vol 130 (4) ◽  
pp. 885-895 ◽  
Author(s):  
Mette Opstrup Abildgaard ◽  
Michael Borre ◽  
Martin Mørck Mortensen ◽  
Benedicte P. Ulhøi ◽  
Niels Tørring ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zinc Finger ◽  
Poor Prognosis ◽  
Zinc Finger Protein ◽  
Promoter Hypermethylation ◽  
Finger Protein

An anti-inflammatory role of A20 zinc finger protein during trauma combined with endotoxin challenge

2013 ◽  
Vol 185 (2) ◽  
pp. 717-725 ◽  
Author(s):  
Bo Liu ◽  
Dianming Jiang ◽  
Yunsheng Ou ◽  
Zhenming Hu ◽  
Jianxin Jiang ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Endotoxin Challenge ◽  
Finger Protein ◽  
Anti Inflammatory

scholarly journals The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus

2005 ◽  
Vol 34 (1) ◽  
pp. 107-118 ◽  
Author(s):  
J Kim ◽  
L Jia ◽  
M R Stallcup ◽  
G A Coetzee
Keyword(s):  
Prostate Cancer ◽  
Signal Transduction ◽  
Androgen Receptor ◽  
Protein Kinase ◽  
Specific Antigen ◽  
Element Binding Protein ◽  
Responsive Element ◽  
Camp Responsive Element Binding ◽  
Kinase A ◽  
Androgen Independent

Androgen-independent prostate cancer is a lethal form of the disease that is marked by metastasis and rapid proliferation in its final stages. As no effective therapy for this aggressive tumor currently exists, it is imperative to elucidate and target the mechanisms involved in the progression to androgen independence. Accumulating evidence indicates that aberrant activation of androgen receptor (AR) via signal transduction pathways, AR gene mutation and/or amplification, and/or coregulator alterations may contribute to the progression of prostate cancer. In the present study, the effects of protein kinase A (PKA) signaling and its downstream factors on AR activity at the prostate-specific antigen (PSA) gene were tested. Activation of PKA by forskolin resulted in enhanced androgen-induced expression of the PSA gene, an effect that was blocked by the AR antagonist, bicalutamide. Interestingly, when either p300 or CBP was overexpressed, PKA activation was sufficient to stimulate PSA promoter-driven transcription in the absence of androgen, which was not inhibited by bicalutamide. PKA activation did not significantly alter AR protein levels but significantly increased the phosphorylated form of its downstream effector, cAMP responsive element-binding protein (CREB) in the presence of androgen. Furthermore, chromatin immunoprecipitation showed that the combination of androgen and forskolin increased phosphorylated CREB occupancy, which was accompanied by histone acetylation, at the putative cAMP responsive element located in the 5′ upstream regulatory region of the PSA gene. Remarkably, mammalian two-hybrid assay indicated that p300/CBP may bridge the interaction between AR and CREB, suggesting a novel enhanceosomal cooperation. These results demonstrate an intriguing interplay between a signal transduction pathway, coactivator overexpression and AR signaling as a possible combined mechanism of progression to androgen-independent prostate cancer.

Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor

2010 ◽  
Vol 91 (6) ◽  
pp. 1494-1502 ◽  
Author(s):  
S. Kaufmann ◽  
M. Sauter ◽  
M. Schmitt ◽  
B. Baumert ◽  
B. Best ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Finger Protein

scholarly journals hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1)

The Prostate ◽  
2011 ◽  
Vol 71 (14) ◽  
pp. 1518-1524 ◽  
Author(s):  
Jing Zou ◽  
Beatrice C. Milon ◽  
Mohamed M. Desouki ◽  
Leslie C. Costello ◽  
Renty B. Franklin
Keyword(s):  
Prostate Cancer ◽  
Binding Protein ◽  
Zinc Transporter ◽  
Down Regulation ◽  
Element Binding Protein ◽  
Responsive Element

Abstract 5045: Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.

2013 ◽  
Author(s):  
Raffaella Spina ◽  
Gessica Filocamo ◽  
Enrico Iaccino ◽  
Stefania Scicchitano ◽  
Michela Lupia ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Critical Role ◽  
Finger Protein ◽  
Tumorigenic Potential

Role of the Tristetraprolin (Zinc Finger Protein 36 Homolog) Gene in Cancer

2018 ◽  
Vol 28 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Gaurav Gupta ◽  
Mary Bebawy ◽  
Terezinha de Jesus Andreoli Pinto ◽  
Dinesh Kumar Chellappan ◽  
Anurag Mishra ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein
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