Advanced glycation end‐products (AGEs) are lower in prostate tumor tissue and inversely related to proportion of West African ancestry

The Prostate ◽  
2021 ◽  
Author(s):  
Morgan L. Zenner ◽  
Yves B. Helou ◽  
Ryan J. Deaton ◽  
Maria Sverdlov ◽  
Heng Wang ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Tumor Tissue ◽  
African Ancestry ◽  
West African ◽  
Prostate Tumor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
West African Ancestry

scholarly journals Consumption of Dietary Advanced Glycation End Products Promotes Prostate Tumor Growth by Creating a Tumor Enhancing Stromal Microenvironment

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 359-359
Author(s):  
David Turner ◽  
Bradley Krisanits ◽  
Callan Frye ◽  
Lourdes Nogueira ◽  
Ried Schuster ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tumor Growth ◽  
Advanced Glycation End Products ◽  
Prostate Tumor ◽  
Migration And Invasion ◽  
Advanced Glycation ◽  
Neoplastic Growth ◽  
Incidence And Mortality ◽  
Glycation End Products ◽  
End Products

Abstract Objectives The literature regarding the role of advanced glycation end products (AGEs) on tumor biology has shown only moderate promise reflected by increases in cell growth, migration and invasion in vitro which is not supported by increased tumor growth in vivo14-16– A caveat to these studies is that they are centered upon a single AGE peptide and a subsequent assessment of their molecular effects on tumor epithelial cells. The objective is to show that by feeding mice a high AGE diet we can recapitulate a microenvironment comprising of a wide spectrum of AGEs which can influence neoplastic growth. Methods We recapitulated a dietary-AGE induced microenvironment in syngeneic xenograft and spontaneous breast and prostate mouse cancer models and the effects on tumor growth assessed. The mechanistic consequences of dietary-AGEs on the tumor microenvironment were further defined using mouse and human primary and immortalized two-compartment co-culture ex vivo culture models. Results Dietary-AGE consumption in breast and prostate tumor models significantly accelerated tumor growth by functioning as ligand to the transmembrane receptor for AGE (RAGE). Our studies demonstrate that AGEs promote neoplastic growth by functioning as ligand to RAGE expressed in the tumor stroma not the tumor epithelial cells. Dietary-AGE activation of RAGE in both breast and prostate tumors caused a regulatory program of ‘activated fibroblasts’ defined by increased expression of cancer associated fibroblast markers, NFkB and MYC upregulation, and pro-tumorigenic paracrine secretion. Complementary to this, our published studies show that high intake of dietary AGE after BCa diagnosis increases risk of mortality in postmenopausal women. Conclusions These data demonstrate, for the first time, the oncogenic potential of dietary-AGEs in promoting neoplastic growth. This lays the foundation for strategic changes aimed at reducing cancer incidence and mortality as pharmacological, educational and/or interventional strategies aimed at reducing the dietary-AGE accumulation pool may one day be viewed as universal cancer preventative and/or therapeutic initiatives especially when combined with existing therapies. Funding Sources David P. Turner was supported by grants from the NIH/NCI, R21 CA194469 and U54 CA21096..

Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth

2012 ◽  
Vol 417 (4) ◽  
pp. 1133-1138 ◽  
Author(s):  
Indira Elangovan ◽  
Sivasakthivel Thirugnanam ◽  
Aoshuang Chen ◽  
Guoxing Zheng ◽  
Maarten C. Bosland ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Advanced Glycation End Products ◽  
Prostate Tumor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Rage Expression

Der Rezeptor für advanced glycation end products (RAGE) mediiert Inflammation und fördert Tumorentstehung durch Interaktion mit Apoptosesignalwegen

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
M Brune ◽  
T Schilling ◽  
W Stremmel ◽  
PH Krammer ◽  
A Bierhaus ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Concentration time profiles of plasma pentosidine in healthy volunteers following a breakfast rich in advanced glycation end products

2009 ◽  
Vol 34 (03) ◽  
Author(s):  
G Faustmann ◽  
I Sundl ◽  
A Meinitzer ◽  
M Maritschnegg ◽  
B Tiran ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Time Profiles ◽  
Concentration Time ◽  
Glycation End Products ◽  
End Products
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