Role of phosphorylation in conformational adaptability of bovine myelin basic protein

1990 ◽  
Vol 7 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Gladys E. Deibler ◽  
Audrey L. Stone ◽  
Marian W. Kies
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein

scholarly journals Role of Very-late Antigen-4 (VLA-4) in Myelin Basic Protein-primed T Cell Contact-induced Expression of Proinflammatory Cytokines in Microglial Cells

2003 ◽  
Vol 278 (25) ◽  
pp. 22424-22431 ◽  
Author(s):  
Subhajit Dasgupta ◽  
Malabendu Jana ◽  
Xiaojuan Liu ◽  
Kalipada Pahan
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Proinflammatory Cytokines ◽  
Basic Protein ◽  
Microglial Cells ◽  
Cell Contact ◽  
Induced Expression ◽  
Late Antigen

scholarly journals Myelin Basic Protein-Specific TCR/HLA-DRB5*01:01 Transgenic Mice Support the Etiologic Role of DRB5*01:01 in Multiple Sclerosis

2012 ◽  
Vol 189 (6) ◽  
pp. 2897-2908 ◽  
Author(s):  
Jacqueline A. Quandt ◽  
Jaebong Huh ◽  
Mirza Baig ◽  
Karen Yao ◽  
Naoko Ito ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Transgenic Mice ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Etiologic Role

Lack of evidence for a role of the myelin basic protein gene in multiple sclerosis susceptibility in Sardinian patients

2002 ◽  
Vol 249 (11) ◽  
pp. 1552-1555 ◽  
Author(s):  
Eleonora Cocco ◽  
Cristina Mancosu ◽  
Elisabetta Fadda ◽  
Maria Rita Murru ◽  
Gianna Costa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Protein Gene ◽  
Multiple Sclerosis Susceptibility ◽  
Myelin Basic Protein Gene

The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation

1988 ◽  
Vol 444 (1) ◽  
pp. 195-198 ◽  
Author(s):  
David Johnson ◽  
Pierrette A. Seeldrayers ◽  
Howard L. Weiner
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Mast Cell Degranulation ◽  
Myelin Proteins

Crucial Role of CCL3/MIP-1α in the Recurrence of Autoimmune Anterior Uveitis Induced with Myelin Basic Protein in Lewis Rats

2002 ◽  
Vol 18 (4) ◽  
pp. 259-270 ◽  
Author(s):  
Maria Manczak ◽  
Shuguang Jiang ◽  
Beata Orzechowska ◽  
Grazyna Adamus
Keyword(s):  
Myelin Basic Protein ◽  
Anterior Uveitis ◽  
Crucial Role ◽  
Basic Protein ◽  
Lewis Rats

scholarly journals The role of polymorphic I-Ak beta chain residues in presentation of a peptide from myelin basic protein.

1989 ◽  
Vol 169 (6) ◽  
pp. 2239-2244 ◽  
Author(s):  
C B Davis ◽  
J M Buerstedde ◽  
D J McKean ◽  
P P Jones ◽  
H O McDevitt ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Antigen Presentation ◽  
Basic Protein ◽  
Mutant Cell ◽  
Peptide Binding ◽  
Beta Chain ◽  
Wild Type ◽  
Cell Clones ◽  
Peptide Interactions

Proteins encoded by genes in the MHC are highly polymorphic. For class II proteins the highest level of polymorphism is found in distinct regions of variability, notably in the membrane-distal domains. To investigate the role of such residues in antigen presentation, we have tested cells transfected with wild-type or mutant I-Ak beta chains for their ability to present the NH2-terminal peptide of myelin basic protein to a panel of T cell clones. We were unable to detect a gross effect on peptide binding, in that all of the mutant cell lines presented antigen to at least one of the cloned T cells. However, the results imply that the more NH2-terminal residues, particularly 12 and 14, are involved in peptide interactions. Mutations at these residues presented antigen only at high antigen concentrations. Furthermore, residues of the more COOH-terminal regions appear to determine TCR interactions. Mutations in the predicted alpha-helical regions of the beta chain affected antigen presentation without abolishing peptide binding.

Comparison of Proposed Putative Active Conformations of Myelin Basic Protein Epitope 87−99 Linear Altered Peptide Ligands by Spectroscopic and Modelling Studies:  The Role of Positions 91 and 96 in T-Cell Receptor Activation

2006 ◽  
Vol 49 (23) ◽  
pp. 6683-6691 ◽  
Author(s):  
Efthimia D. Mantzourani ◽  
Theodore V. Tselios ◽  
Simona Golic Grdadolnik ◽  
James A. Platts ◽  
Andrea Brancale ◽  
...  
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
T Cell Receptor ◽  
Basic Protein ◽  
Cell Receptor ◽  
Receptor Activation ◽  
Peptide Ligands ◽  
Altered Peptide Ligands ◽  
Modelling Studies
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