Evaluation of antifungal activities and structure-activity relationships of coumarin derivatives

2016 ◽  
Vol 73 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Ping-Ping Song ◽  
Jun Zhao ◽  
Zong-Liang Liu ◽  
Ya-Bing Duan ◽  
Yi-Ping Hou ◽  
...  
Keyword(s):  
Coumarin Derivatives ◽  
Antifungal Activities ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity

2013 ◽  
Vol 14 (1) ◽  
pp. 1293-1309 ◽  
Author(s):  
Rodrigo de Araújo ◽  
Felipe Guerra ◽  
Edeltrudes de O. Lima ◽  
Carlos de Simone ◽  
Josean Tavares ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
In Silico ◽  
Coumarin Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
In Silico Studies

scholarly journals Design, characterization, in vitro antibacterial, antitubercular evaluation and structure–activity relationships of new hydrazinyl thiazolyl coumarin derivatives

2017 ◽  
Vol 26 (6) ◽  
pp. 1139-1148 ◽  
Author(s):  
Samina KhanYusufzai ◽  
Hasnah Osman ◽  
Mohammad Shaheen Khan ◽  
Suriyati Mohamad ◽  
Othman Sulaiman ◽  
...  
Keyword(s):  
Coumarin Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and antifungal activities of 3-substituted phthalide derivatives

2019 ◽  
Vol 74 (11-12) ◽  
pp. 811-818 ◽  
Author(s):  
Lingling Fan ◽  
Bilan Luo ◽  
Zhongfu Luo ◽  
Li Zhang ◽  
Judi Fan ◽  
...  
Keyword(s):  
Growth Rate ◽  
Bioactive Compounds ◽  
Mycelial Growth ◽  
Phytopathogenic Fungi ◽  
Antifungal Activities ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Mycelial Growth Rate ◽  
Rate Method

AbstractIn order to obtain novel bioactive compounds with significant antifungal activities, two series of 3-substituted phthalide derivatives were designed and synthesized via reduction, bromine substitution, and etherification. In addition, the antifungal activities of all target compounds against nine phytopathogenic fungi in vitro were tested by using the mycelial growth rate method at the concentration of 50 μg mL−1. Preliminary bioassay tests showed that some compounds exhibited more potent antifungal activities as compared with hymexazol. The preliminary structure-activity relationships (SARs) of all target compounds were also investigated.

Bis-coumarin Derivatives and Their Biological Activities

2018 ◽  
Vol 18 (2) ◽  
pp. 101-113 ◽  
Author(s):  
Qing-Cheng Ren ◽  
Chuan Gao ◽  
Zhi Xu ◽  
Lian-Shun Feng ◽  
Ming-Liang Liu ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Active Sites ◽  
Noncovalent Interactions ◽  
Biological Activities ◽  
Coumarin Derivatives ◽  
Antitumor Activities ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Biological Potential

Bis-coumarins have caused great interests in the recent years. These compounds exhibit diverse biological activities which are ascribed to their ability to exert noncovalent interactions with the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous biscoumarin derivatives have been synthesized and screened for their biological activities, and many of them showed promising potency. This review is focused on the biological potential of bis-coumarin derivatives with particular mention of those exhibiting antibacterial, anticoagulant, antiinflammatory, antiviral, anti-parasite and antitumor activities, and their structure-activity relationships are also discussed.

Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure–activity relationships

2014 ◽  
Vol 105 ◽  
pp. 101-108 ◽  
Author(s):  
Markus Bohnert ◽  
Hans-Wilhelm Nützmann ◽  
Volker Schroeckh ◽  
Fabian Horn ◽  
Hans-Martin Dahse ◽  
...  
Keyword(s):  
Antifungal Activities ◽  
Structure Activity Relationships ◽  
Structure Activity
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