A new FcεRI receptor-mimetic peptide (PepE) that blocks IgE binding to its high affinity receptor and prevents mediator release from RBL 2H3 cells

2011 ◽  
Vol 17 (9) ◽  
pp. 604-609 ◽  
Author(s):  
Annamaria Sandomenico ◽  
Simona M. Monti ◽  
Rosanna Palumbo ◽  
Menotti Ruvo
Keyword(s):  
Mediator Release ◽  
Mimetic Peptide ◽  
High Affinity ◽  
Ige Binding ◽  
High Affinity Receptor ◽  
Affinity Receptor

Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor

1996 ◽  
Vol 3 (5) ◽  
pp. 419-426 ◽  
Author(s):  
J.M. McDonnell ◽  
A.J. Beavil ◽  
G.A. Mackay ◽  
B.A. Jameson ◽  
R. Korngold ◽  
...  
Keyword(s):  
High Affinity ◽  
Ige Binding ◽  
High Affinity Receptor ◽  
Affinity Receptor

scholarly journals The High-Affinity Receptor for IgE Is the Predominant IgE-Binding Structure in Lesional Skin of Atopic Dermatitis Patient

1997 ◽  
Vol 108 (3) ◽  
pp. 336-342 ◽  
Author(s):  
Radek Klubal ◽  
Birgit Osterhoff ◽  
Binghe Wang ◽  
Jean-Pierre Kinet ◽  
Dieter Maurer ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Atopic Dermatitis Patient ◽  
Lesional Skin ◽  
High Affinity ◽  
Ige Binding ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Binding Structure

Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor FcεRI

1997 ◽  
Vol 25 (2) ◽  
pp. 387-392 ◽  
Author(s):  
J. M. McDonnell ◽  
A. J. Beavil ◽  
G. A. Mackay ◽  
A. J. Henry ◽  
J. P. D. Cook ◽  
...  
Keyword(s):  
High Affinity ◽  
Ige Binding ◽  
High Affinity Receptor ◽  
Affinity Receptor

scholarly journals IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 145
Author(s):  
Leonardo Cristinziano ◽  
Remo Poto ◽  
Gjada Criscuolo ◽  
Anne Lise Ferrara ◽  
Maria Rosaria Galdiero ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Lung ◽  
Protein A ◽  
Protein L ◽  
Variable Regions ◽  
Prolonged Incubation ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Pleiotropic Functions

Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are strategically located in different compartments of human lung, where they play a role in several inflammatory disorders and cancer. Immunoglobulin superantigens (e.g., protein A of Staphylococcus aureus and protein L of Peptostreptococcus magnus) bind to the variable regions of either the heavy (VH3) or light chain (κ) of IgE. IL-33 is a cytokine expressed by epithelial cells that exerts pleiotropic functions in the lung. The present study investigated whether immunoglobulin superantigens protein A and protein L and IL-33 caused the release of inflammatory (histamine), angiogenic (VEGF-A) and lymphangiogenic (VEGF-C) factors from HLMCs. The results show that protein A and protein L induced the rapid (30 min) release of preformed histamine from HLMCs. By contrast, IL-33 did not induce the release of histamine from lung mast cells. Prolonged incubation (12 h) of HLMCs with superantigens and IL-33 induced the release of VEGF-A and VEGF-C. Preincubation with IL-33 potentiated the superantigenic release of histamine, angiogenic and lymphangiogenic factors from HLMCs. Our results suggest that IL-33 might enhance the inflammatory, angiogenic and lymphangiogenic activities of lung mast cells in pulmonary disorders.

The Temporal Distribution of the 1α,25-Dihydroxycholecalciferol Receptor in the Rat Jejunal Villus

1984 ◽  
Vol 67 (3) ◽  
pp. 285-290 ◽  
Author(s):  
S. D. H. Chan ◽  
D. Atkins
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Calcium Absorption ◽  
Sedimentation Coefficient ◽  
Temporal Distribution ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Cell Fractions ◽  
Crypt Cells

1. The distribution of the 1α,25-dihydroxycholecalciferol receptor was studied in enterocytes isolated from the upper, mid and lower villus and crypt cells of the jejunum of normal and rachitic rats. 2. In all cell fractions a high-affinity receptor (KD ⋍ 0.07 nmol/l) with a sedimentation coefficient of 3.5S was demonstrated. 3. In normal rats there was a 60% reduction in receptor numbers in crypt cells compared with the mid and upper villous cells. 4. Vitamin D deficiency led to a reduction in receptor numbers in all cell fractions (45% upper villus, 78% crypt cells). 5. The data are compatible with the concept of calcium absorption occurring in the differentiated villous cells and also account for the reduction in absorption in rachitic animals.

scholarly journals Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

Neuron ◽  
1997 ◽  
Vol 19 (3) ◽  
pp. 547-559 ◽  
Author(s):  
Hang Chen ◽  
Alain Chédotal ◽  
Zhigang He ◽  
Corey S Goodman ◽  
Marc Tessier-Lavigne
Keyword(s):  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor
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