Hypolipidemic Effect and Mechanism of Palmatine from Coptis chinensis in Hamsters Fed High-Fat diet

2015 ◽  
Vol 29 (5) ◽  
pp. 668-673 ◽  
Author(s):  
Na Ning ◽  
Kai He ◽  
Yanzhi Wang ◽  
Zongyao Zou ◽  
Hao Wu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Effect ◽  
High Fat ◽  
Coptis Chinensis

Perinatal maternal high-fat diet promotes alterations in hepatic lipid metabolism and resistance to the hypolipidemic effect of fish oil in adolescent rat offspring

2016 ◽  
Vol 60 (11) ◽  
pp. 2493-2504 ◽  
Author(s):  
Lorraine S. Oliveira ◽  
Luana L. Souza ◽  
Aline F. P. Souza ◽  
Aline Cordeiro ◽  
George E. G. Kluck ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fish Oil ◽  
High Fat Diet ◽  
Hypolipidemic Effect ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Rat Offspring

scholarly journals Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

2018 ◽  
Vol 19 (12) ◽  
pp. 4023 ◽  
Author(s):  
Pengpeng Hua ◽  
Zhiying Yu ◽  
Yu Xiong ◽  
Bin Liu ◽  
Lina Zhao
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Spirulina Platensis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Public Health Issue ◽  
Peroxisome Proliferator ◽  
Hypolipidemic Effect ◽  
High Fat

Lipid metabolism disorder (LMD) is a public health issue. Spirulina platensis is a widely used natural weight-reducing agent and Spirulina platensis is a kind of protein source. In the present study, we aimed to evaluate the effect of Spirulina platensis protease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Our study showed that SPPH decreased the levels of triglyceride (TG), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), and aspartate transaminase (AST), but increased the level of high-density-lipoprotein cholesterol (HDL-c) in serum and liver. Moreover, SPPH had a hypolipidemic effect as indicated by the down-regulation of sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl CoA carboxylase (ACC), SREBP-1c, and peroxisome proliferator-activated receptor-γ (PPARγ) and the up-regulation of adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) and peroxisome proliferator-activated receptorα (PPARα) at the mRNA level in liver. SPPH treatment enriched the abundance of beneficial bacteria. In conclusion, our study showed that SPPH might be produce glucose metabolic benefits in rats with diet-induced LMD. The mechanisms underlying the beneficial effects of SPPH on the metabolism remain to be further investigated. Collectively, the above-mentioned findings illustrate that Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders, and our data provides evidence that SPPH might be used as an adjuvant therapy and functional food in obese and diabetic individuals.

scholarly journals Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet

2018 ◽  
Vol 7 (4) ◽  
pp. 252-259 ◽  
Author(s):  
Ayman Mohammed El-Anany ◽  
Rehab Farouk M. Ali
Keyword(s):  
High Fat Diet ◽  
Hypolipidemic Effect ◽  
High Fat

scholarly journals Passiflora edulis seed oil from west Cameroon: Chemical characterization and assessment of its hypolipidemic effect in high‐fat diet–induced rats

2019 ◽  
Vol 7 (11) ◽  
pp. 3751-3758
Author(s):  
Prosper Ngakou Takam ◽  
Fabrice Tonfack Djikeng ◽  
Dieudonné Kuate ◽  
Anne Pascale Nouemsi Kengne ◽  
Hermine Doungué Tsafack ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Seed Oil ◽  
Chemical Characterization ◽  
Hypolipidemic Effect ◽  
High Fat ◽  
Passiflora Edulis

The Mixture of Anemarrhena asphodeloides and Coptis chinensis Attenuates High-Fat Diet-Induced Colitis in Mice

2017 ◽  
Vol 45 (05) ◽  
pp. 1033-1046 ◽  
Author(s):  
Su-Min Lim ◽  
Hyun-Sik Choi ◽  
Dong-Hyun Kim
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Macrophage Activation ◽  
Myeloperoxidase Activity ◽  
High Fat ◽  
Trinitrobenzenesulfonic Acid ◽  
Coptis Chinensis ◽  
Induced Differentiation ◽  
Necrosis Factor Alpha ◽  
Anemarrhena Asphodeloides

Anemarrhena asphodeloides (AA, family Liliaceae) inhibits macrophage activation by inhibiting IRAK1 phosphorylation and helper T (Th)17 differentiation. Coptis chinensis (CC, family Ranunculaceae), which inhibits macrophage activation by inhibiting the binding of lipopolysaccharide (LPS) on toll-like receptor 4 and inducing regulatory T (Treg) cell differentiation. The mixture of AA and CC (AC-mix) synergistically attenuates 2,4,6-trinitrobenzenesulfonic acid or dextran sulfate sodium-induced colitis in mice by inhibiting NF-[Formula: see text]B activation and regulating Th17/Treg balance. In the present study, we examined the effect of AC-mix on high-fat diet (HFD)-induced colitis in mice, which induced NF-[Formula: see text]B activation and disturbed Th17/Treg balance. Long-term feeding of HFD in mice caused colitis, including increased macroscopic score and myeloperoxidase activity. Oral administration of AC-mix (20[Formula: see text]mg/kg) suppressed HFD-induced myeloperoxidase activity by 68% ([Formula: see text]). Furthermore, treatment with the AC-mix (20[Formula: see text]mg/kg) inhibited HFD-induced activation of NF-[Formula: see text]B and expression of cyclooxygenase-2, inducible NO synthase, interleukin (IL)-17, and tumor necrosis factor-alpha but increased HFD- suppressed expression of IL-10. AC-mix suppressed HFD-induced differentiation into Th17 cells by 46% ([Formula: see text]) and increased HFD-induced differentiation into regulatory T cells 2.2-fold ([Formula: see text]). AC-mix also suppressed the HFD-induced Proteobacteria/Bacteroidetes ratio on the gut microbiota by 48% ([Formula: see text]). These findings suggest that AC-mix can ameliorate HFD-induced colitis by regulating innate and adaptive immunities and correcting the disturbance of gut microbiota.

Hypolipidemic effect of oleanolic acid is mediated by the miR‐98‐5p/PGC‐1β axis in high‐fat diet‐induced hyperlipidemic mice

2016 ◽  
Vol 31 (3) ◽  
pp. 1085-1096 ◽  
Author(s):  
Siyu Chen ◽  
Xiaoan Wen ◽  
Wenxiang Zhang ◽  
Chen Wang ◽  
Jun Liu ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
High Fat Diet ◽  
Hypolipidemic Effect ◽  
High Fat
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