Bilobalide protects astrocytes from oxygen and glucose deprivation‐induced oxidative injury by upregulating manganese superoxide dismutase

2019 ◽  
Vol 33 (9) ◽  
pp. 2329-2336 ◽  
Author(s):  
Jun Xiang ◽  
Jingsi Zhang ◽  
Xiaofang Cai ◽  
Feng Yang ◽  
Wen Zhu ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Oxidative Injury ◽  
Glucose Deprivation ◽  
Oxygen And Glucose Deprivation ◽  
Manganese Superoxide

Polysaccharide Krestin Enhances Manganese Superoxide Dismutase Activity and mRNA Expression in Mouse Peritoneal Macrophages

2000 ◽  
Vol 28 (03n04) ◽  
pp. 331-341 ◽  
Author(s):  
Zhan-Jun Pang ◽  
Yuan Chen ◽  
Mei Zhou
Keyword(s):  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Tumor Therapy ◽  
Density Lipoprotein ◽  
Oxidative Injury ◽  
Peritoneal Macrophages ◽  
Sod Activity ◽  
Manganese Superoxide ◽  
Mouse Peritoneal Macrophages ◽  
Mnsod Activity

Manganese superoxide dismutase (MnSOD), an inductive antioxidant enzyme, can protect cells from oxidative injury to the mitochondria. The elevation of MnSOD activity in cells can effectively prevent many diseases associated with oxidative stress. Polysaccharide Krestin (PSK), a kind of protein-bound polysaccharide extracted from Coriolus versicolor, is used as an immune response modifier in anti-tumor therapy. We have previously found that PSK could alleviate the oxidative injury that oxidized low density lipoprotein (Ox-LDL) brought to monocytes/macrophages, and therefore had some preventive or therapeutic effect on atherosclerosis. In order to find out if the effects of PSK were associated with the alteration of antioxidant enzymes, we investigated its effect on MnSOD activity and gene expression in mouse peritoneal macrophages. The results showed that PSK could enhance SOD activity and increase the contents of MnSOD mRNA in mouse peritoneal macrophages. Furthermore, the induction of MnSOD by PSk could be blocked by cycloheximide and actinomycin D.

Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells.

2021 ◽  
pp. 105825
Author(s):  
Giacomo Russo ◽  
Giulia Iaccarino ◽  
Marialuisa Piccolo ◽  
Maria Grazia Ferraro ◽  
Raffaele Vecchione ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cancer Cells ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide

scholarly journals Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute Adriamycin-induced mitochondrial toxicity

2005 ◽  
Vol 4 (7) ◽  
pp. 1056-1064 ◽  
Author(s):  
Luksana Chaiswing ◽  
Marsha P. Cole ◽  
Wanida Ittarat ◽  
Luke I. Szweda ◽  
Daret K. St. Clair ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Manganese Superoxide Dismutase ◽  
Mitochondrial Toxicity ◽  
Manganese Superoxide ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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