Ginsenoside Re protects against chronic restraint stress‐induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice

2021 ◽  
Author(s):  
Haixia Wang ◽  
Jingwei Lv ◽  
Ning Jiang ◽  
Hong Huang ◽  
Qiong Wang ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
Ginsenoside Re

Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice

2015 ◽  
Vol 288 ◽  
pp. 1-10 ◽  
Author(s):  
Pengcheng Huang ◽  
Cai Li ◽  
Tianli Fu ◽  
Dan Zhao ◽  
Zhen Yi ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
Male Mice ◽  
Hippocampal Apoptosis

Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice

2017 ◽  
Vol 33 (2) ◽  
pp. 421-431 ◽  
Author(s):  
Gwladys Temkou Ngoupaye ◽  
Francis Bray Yassi ◽  
Doriane Amanda Nguepi Bahane ◽  
Elisabeth Ngo Bum
Keyword(s):  
Cognitive Deficits ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
Corticosterone Treatment

Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice

Life Sciences ◽  
2020 ◽  
Vol 258 ◽  
pp. 118107 ◽  
Author(s):  
Haixia Wang ◽  
Ning Jiang ◽  
Jingwei Lv ◽  
Hong Huang ◽  
Xinmin Liu
Keyword(s):  
Cognitive Deficits ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
Ginsenoside Rd ◽  
Creb Pathway

scholarly journals Chronic restraint stress impairs cognition via modulating HDAC2 expression

2021 ◽  
Vol 12 (1) ◽  
pp. 154-163
Author(s):  
Jie Wu ◽  
Cui Liu ◽  
Ling Zhang ◽  
Bing He ◽  
Wei-Ping Shi ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurons ◽  
Restraint Stress ◽  
Glucocorticoid Receptors ◽  
Chronic Restraint Stress ◽  
Akt Signaling Pathway ◽  
Object Recognition Test ◽  
Protein Levels ◽  
Synaptic Functions ◽  
Plus Maze

Abstract Background To investigate the effects of chronic restraint stress on cognition and the probable molecular mechanism in mice. Methods In the current work, a restraining tube was used as a way to induce chronic stress in mice. The protein levels were determined with ELISA and western blot. A series of behavior tests, including the Morris water maze, elevated plus maze, open field test, and novel object recognition test, were also performed to examine the anxiety and the ability of learning and memory. Moreover, murine neuroblastoma N2a cells were used to confirm the findings from mice under chronic stress. Results Decreased synaptic functions were impaired in chronic stress with the downregulation of PSD95, GluR-1, the neurotrophic factor BDNF, and immediate-onset genes Arc and Egr. Chronic restraint decreased the histone acetylation level in hippocampal neurons while HDAC2 was increased and was co-localized with glucocorticoid receptors. Moreover, chronic stress inhibited the PI3K/AKT signaling pathway and induced energy metabolism dysfunctions. Conclusion This work examining the elevated levels of HDAC2 in the hippocampus may provide new insights and targets for drug development for treating many neurodegenerative diseases.

Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

2020 ◽  
Vol 18 (11) ◽  
pp. 872-880
Author(s):  
Ying-Li ZHU ◽  
Lin-Yuan WANG ◽  
Dan-Ping ZHAO ◽  
Cheng-Long WANG ◽  
Rui ZHANG ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
No Signaling

Effects of acute and chronic restraint stress on nitroglycerin-induced hyperalgesia in rats

2005 ◽  
Vol 383 (1-2) ◽  
pp. 7-11 ◽  
Author(s):  
A. Costa ◽  
A. Smeraldi ◽  
C. Tassorelli ◽  
R. Greco ◽  
G. Nappi
Keyword(s):  
Restraint Stress ◽  
Chronic Restraint Stress

scholarly journals Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF- β 1 generation

2014 ◽  
Vol 5 (6) ◽  
pp. e1308-e1308 ◽  
Author(s):  
X Yang ◽  
Z-P Han ◽  
S-S Zhang ◽  
P-X Zhu ◽  
C Hao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Injury ◽  
Restraint Stress ◽  
Chronic Restraint Stress
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