scholarly journals Identification of novel biomarkers of hepatocellular carcinoma by high‐definition mass spectrometry: Ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging

2020 ◽  
Vol 34 (S1) ◽  
Author(s):  
Koshi Nagai ◽  
Baasanjav Uranbileg ◽  
Zhen Chen ◽  
Amane Fujioka ◽  
Takahiro Yamazaki ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Hepatocellular Carcinoma ◽  
Liquid Chromatography ◽  
Mass Spectrometry Imaging ◽  
Desorption Electrospray Ionization ◽  
Ionization Mass ◽  
High Definition ◽  
Flight Mass Spectrometry ◽  
Novel Biomarkers ◽  
Ultrahigh Performance Liquid Chromatography

scholarly journals Metabolomic estimation of the diagnosis of hepatocellular carcinoma based on ultrahigh performance liquid chromatography coupled with time-of-flight mass spectrometry

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9375-9382 ◽  
Author(s):  
Yuan-Feng Li ◽  
Shi Qiu ◽  
Li-Juan Gao ◽  
Ai-Hua Zhang
Keyword(s):  
Mass Spectrometry ◽  
Hepatocellular Carcinoma ◽  
Liquid Chromatography ◽  
Time Of Flight ◽  
Disease Diagnosis ◽  
Flight Mass Spectrometry ◽  
Ultrahigh Performance Liquid Chromatography

Metabolomics has been shown to be an effective tool for biomarker screening and pathway characterization and disease diagnosis.

scholarly journals Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study onCornus officinalis

2013 ◽  
Vol 2013 ◽  
pp. 1-10
Author(s):  
Gang Cao ◽  
Hao Cai ◽  
Xianke Yue ◽  
Sicong Tu ◽  
Baochang Cai ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Herbal Medicine ◽  
Rice Wine ◽  
Rat Urine ◽  
Flight Mass Spectrometry ◽  
Cornus Officinalis ◽  
Ultrahigh Performance Liquid Chromatography ◽  
Main Components

Ultrahigh-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS) was developed for rapid and sensitive analysis of the effect of rice wine on the metabolites of the main components of herbal medicine in rat urine. UsingCornus officinalisas a model of herbal medicine, the metabolite profiles of crude and processed (steaming the crude drug presteeped in rice wine)Cornus officinalisextracts in rat urine were investigated. The metabolites ofCornus officinaliswere identified by using dynamic adjustment of the fragmentor voltage to produce structure-relevant fragment ions. In this work, we identified the parent compounds and metabolites of crude and processedCornus officinalisin rats. In total, three parent compounds and seventeen new metabolites ofCornus officinaliswere found in rats. The contents of the parent compounds and metabolitesin vivovaried significantly after intragastric (i.g.) administration of aqueous extracts of crude and processedCornus officinalis. Data from this study suggests that UPLC-QTOF/MS could be used as a potential tool for uncovering the effects of excipients found in the metabolites of the main components of herbal medicine,in vivo, to predict and discover the processing mechanisms of herbal medicine.

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