scholarly journals Optimizing the Production of a Human Umbilical Cord Blood‐Derived Cell Therapy Product, DUOC ‐01

2021 ◽  
Vol 10 (S1) ◽  
Author(s):  
Li Xu ◽  
Roberta Parrott ◽  
Madison French ◽  
Joanne Kurtzberg ◽  
Anthony Filiano
Keyword(s):  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cell Therapy Product

scholarly journals Nanofiber‐expanded human umbilical cord blood–derived CD 34 + cell therapy accelerates cutaneous wound closure in NOD / SCID mice

2014 ◽  
Vol 18 (4) ◽  
pp. 685-697 ◽  
Author(s):  
Suman Kanji ◽  
Manjusri Das ◽  
Reeva Aggarwal ◽  
Jingwei Lu ◽  
Matthew Joseph ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Wound Closure ◽  
Scid Mice ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cutaneous Wound ◽  
Cd 34

Human Umbilical Cord Blood as an Emerging Stem Cell Therapy for Diabetes Mellitus

2010 ◽  
Vol 5 (4) ◽  
pp. 356-361 ◽  
Author(s):  
Alluru S. Reddi ◽  
Kishore Kuppasani ◽  
Norman Ende
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Stem Cell Therapy ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

scholarly journals Experimental research Effects of intravenous human umbilical cord blood CD34+ stem cell therapy versus levodopa

2013 ◽  
Vol 6 ◽  
pp. 1138-1151 ◽  
Author(s):  
Noha Abo-Grisha ◽  
Soha Essawy ◽  
Dina M. Abo-ElMatty ◽  
Zenab Abdel-Hady
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Experimental Research ◽  
Stem Cell Therapy ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cd34

scholarly journals Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy accelerates murine cutaneous wound closure by attenuating pro-inflammatory factors and secreting IL-10

2014 ◽  
Vol 12 (1) ◽  
pp. 275-288 ◽  
Author(s):  
Suman Kanji ◽  
Manjusri Das ◽  
Reeva Aggarwal ◽  
Jingwei Lu ◽  
Matthew Joseph ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Wound Closure ◽  
Inflammatory Factors ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cutaneous Wound

Experimental BPD – cells from human umbilical cord blood improve lung development in a double-hit mouse model

2012 ◽  
Vol 224 (07) ◽  
Author(s):  
D Monz ◽  
E Tutdibi ◽  
CF Mildau ◽  
J Shen ◽  
M Kasoha ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Lung Development ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Double Hit

Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

2019 ◽  
Vol 14 (6) ◽  
pp. 460-465 ◽  
Author(s):  
Jing Jia ◽  
Baitao Ma ◽  
Shaoshuai Wang ◽  
Ling Feng
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Tissue Regeneration ◽  
Umbilical Cord Blood ◽  
Therapeutic Potential ◽  
Human Umbilical Cord Blood ◽  
Proliferative Potential ◽  
Human Umbilical Cord ◽  
Preclinical Studies ◽  
Endothelial Colony Forming Cells

Endothelial progenitor cells (EPCs) are implicated in multiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs’ characteristics, classification and origins, a summary of the progress in preclinical studies with regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions.

Hoechst dye efflux reveals a novel CD7+CD34− lymphoid progenitor in human umbilical cord blood

Blood ◽  
2000 ◽  
Vol 96 (6) ◽  
pp. 2125-2133 ◽  
Author(s):  
Robert W. Storms ◽  
Margaret A. Goodell ◽  
Alan Fisher ◽  
Richard C. Mulligan ◽  
Clay Smith
Keyword(s):  
Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Large Population ◽  
Lymphoid Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Hematopoietic Stem ◽  
Cd34 Cells

Abstract A novel Hoechst 33342 dye efflux assay was recently developed that identifies a population of hematopoietic cells termed side population (SP) cells. In the bone marrow of multiple species, including mice and primates, the SP is composed primarily of CD34−cells, yet has many of the functional properties of hematopoietic stem cells (HSCs). This report characterizes SP cells from human umbilical cord blood (UCB). The SP in unfractionated UCB was enriched for CD34+ cells but also contained a large population of CD34− cells, many of which were mature lymphocytes. SP cells isolated from UCB that had been depleted of lineage-committed cells (Lin− UCB) contained CD34+ and CD34− cells in approximately equivalent proportions. Similar to previous descriptions of human HSCs, the CD34+Lin− SP cells were CD38dimHLA-DRdimThy-1dimCD45RA−CD71−and were enriched for myelo-erythroid precursors. In contrast, the CD34−Lin− SP cells were CD38−HLA-DR−Thy-1−CD71−and failed to generate myelo-erythroid progeny in vitro. The majority of these cells were CD7+CD11b+CD45RA+, as might be expected of early lymphoid cells, but did not express other lymphoid markers. The CD7+CD34−Lin− UCB SP cells did not proliferate in simple suspension cultures but did differentiate into natural killer cells when cultured on stroma with various cytokines. In conclusion, the human Lin− UCB SP contains both CD34+ multipotential stem cells and a novel CD7+CD34−Lin− lymphoid progenitor. This observation adds to the growing body of evidence that CD34− progenitors exist in humans.

scholarly journals Endothelial cell precursors are normal components of human umbilical cord blood

1997 ◽  
Vol 98 (3) ◽  
pp. 775-777 ◽  
Author(s):  
Mie Nieda ◽  
Andrew Nicol ◽  
Patricia Denning‐Kendall ◽  
John Sweetenham ◽  
Ben Bradley ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord
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