Cu II ‐Tyrosinase Enzyme Catalyst‐Mediated Synthesis of 2‐Thioxopyrimidine Derivatives with Potential Mosquito Larvicidal Activity: Spectroscopic and Computational Investigation as well as Molecular Docking Interaction with OBPs of Culex quinquefasciatus

2020 ◽  
Vol 5 (15) ◽  
pp. 4567-4574 ◽  
Author(s):  
Chidambaram SathishKumar ◽  
Selvaraj Keerthana ◽  
Anis Ahamed ◽  
Ibrahim A. Arif ◽  
Radhakrishnan SurendraKumar ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Larvicidal Activity ◽  
Culex Quinquefasciatus ◽  
Computational Investigation ◽  
Mosquito Larvicidal Activity ◽  
Enzyme Catalyst ◽  
Tyrosinase Enzyme ◽  
Docking Interaction

scholarly journals Synthesis of novel benzopyran-connected pyrimidine and pyrazole derivatives via a green method using Cu(ii)-tyrosinase enzyme catalyst as potential larvicidal, antifeedant activities

RSC Advances ◽  
2019 ◽  
Vol 9 (44) ◽  
pp. 25533-25543 ◽  
Author(s):  
Ashraf Abdel-Fattah Mostafa ◽  
Chidambaram SathishKumar ◽  
Abdulaziz Abdulrahman Al-Askar ◽  
Shaban R. M. Sayed ◽  
Radhakrishnan SurendraKumar ◽  
...  
Keyword(s):  
Larvicidal Activity ◽  
Pyrazole Derivatives ◽  
Green Method ◽  
Enzyme Catalyst ◽  
Tyrosinase Enzyme

Cu(ii)-tyrosinase catalytic help with the synthesis of benzopyran-connected pyrimidine and pyrazole derivatives and their larvicidal activity.

scholarly journals Tyrosinase enzyme mediated: Synthesis and larvicidal activity of 1,5-diphenyl pent-4-en-1-one derivatives against Culex quinquefasciatus and investigation of Ichthyotoxicity against O. mossambicus

2021 ◽  
Author(s):  
SathishKumar Chidambaram ◽  
Daoud Ali ◽  
Saud Alarifi ◽  
Surendra Kumar Radhakrishnan ◽  
Idhayadhulla Akbar
Keyword(s):  
Larvicidal Activity ◽  
Culex Quinquefasciatus ◽  
Oreochromis Mossambicus ◽  
Docking Studies ◽  
Reaction Conditions ◽  
Mass Spectral ◽  
H Nmr ◽  
Tyrosinase Enzyme ◽  
High Yields ◽  
C Nmr

Abstract Larvicidal activity of 1,5-diphenylpent-4-en-1-one derivatives were synthesized via grindstone method, tyrosinase enzyme used as a catalyst of this process. This method offers high yields with mild reaction conditions. Synthesized compounds were conformed from FTIR, 1H NMR, 13C NMR, mass spectral and elemental analysis. In this study, a total of 17 compounds (1a–1q) were synthesized, and their larvicidal and antifeedant activities were evaluated. Compound 1i (1-(5-oxo-1,5-diphenylpent-1-en-3-yl)-3-(3-phenylallylidene)thiourea) was extremely active (LD50: 12.09 µg/mL) against Culex quinquefasciatus compared with temephos and permethrin, whereas compounds 1i at 100 µg/mL generated 0% mortality within 24h against Oreochromis mossambicus in an antifeedant screening, and Ichthyotoxicity was determined as the death ratio (%) at 24 h. The compounds 1a, 1e, 1f, 1j, and 1k were found to be highly toxic whereas the 1i was not toxic in antifeedant screening. Therefore, 1i was found to have a high larvicidal activity against C. quinquefasciatus, and was non-toxic to non-target aquatic species. Molecular docking studies also supported the finding that 1i is a potent larvicide with more binding energy than the control (-10.0 vs. -7.6 Kcal/mol) in the 3OGN protein. The lead molecule is very important to larvicidal properties and insecticides.

scholarly journals Chemical characterization and mosquito larvicidal activity of essential oil from leaves of Persea americana Mill (Lauraceae) against Culex quinquefasciatus (Say)

2015 ◽  
Vol 5 (6) ◽  
pp. 463-467 ◽  
Author(s):  
Carlos Granados-Echegoyen ◽  
Rafael Pérez-Pacheco ◽  
Nancy Alonso-Hernández ◽  
Alfonso Vásquez-López ◽  
Luicita Lagunez-Rivera ◽  
...  
Keyword(s):  
Essential Oil ◽  
Larvicidal Activity ◽  
Culex Quinquefasciatus ◽  
Chemical Characterization ◽  
Persea Americana ◽  
Mosquito Larvicidal Activity

scholarly journals In vitro Mosquito Larvicidal Activity of Marine Algae Against the Human Vectors, Culex quinquefasciatus (Say) and Aedes aegypti (Linnaeus) (Diptera: Culicidae)

2011 ◽  
Vol 7 (3) ◽  
pp. 272-278 ◽  
Author(s):  
Aseer Manilal ◽  
Nooruddin Thajuddin ◽  
Joseph Selvin ◽  
Akbar Idhayadhul ◽  
Radhakrishnan Surendra K ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Culex Quinquefasciatus ◽  
Marine Algae ◽  
Mosquito Larvicidal Activity
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