Janus Particles: Temperature‐Responsive Janus Particles as Microsurfactants for On‐Demand Coalescence of Emulsions (Small 49/2020)

Temporal elasticity and roughness modulation with temperature-responsive poly(ε-caprolactone) induced the alternation of hepatocellular function dynamically.

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PLA-HPC Fibrous Membranes for Temperature-Responsive Drug Release

Nano Hybrids and Composites ◽

10.4028/www.scientific.net/nhc.18.34 ◽

2017 ◽

Vol 18 ◽

pp. 34-41

Author(s):

Manish Kumar ◽

Dagmar Wengerowsky ◽

Florian Böttcher ◽

Ralf Sindelar ◽

Vesa P. Hytönen ◽

...

Keyword(s):

Methylene Blue ◽

Phase Transitions ◽

Drug Release ◽

Polylactic Acid ◽

Hydroxypropyl Cellulose ◽

External Temperature ◽

Temperature Responsive ◽

On Demand ◽

Hydrophilic Drug ◽

Fibrous Membranes

In this study, Polylactic acid and Hydroxypropyl cellulose (PLA-HPC) fibers were fabricated by electrospinning. Methylene blue (MEB), as a model hydrophilic drug was embedded into PLA-HPC fibrous membranes. SEM results depicted that fibers are smooth, cylindrical, uniform and it confirmed the incorporation of MEB in PLA fibers alter the fibers morphology. Studies show the on-demand release of drug from PLA-HPC fibrous membranes under temperature stimuli which were absent in membranes manufactured out of PLA. This can be attributed to reversible volume phase transitions of HPC molecules in response to applied external temperature. This study may provide more efficient strategies for developing materials with on-demand drug release capability.

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UV-Triggered On-Demand Temperature-Responsive Reversible and Irreversible Gelation of Cellulose Nanocrystals

Biomacromolecules ◽

10.1021/acs.biomac.9b01519 ◽

2020 ◽

Vol 21 (2) ◽

pp. 830-838 ◽

Cited By ~ 1

Author(s):

Christoph Hörenz ◽

Kia Bertula ◽

Tony Tiainen ◽

Sami Hietala ◽

Ville Hynninen ◽

...

Keyword(s):

Cellulose Nanocrystals ◽

Temperature Responsive ◽

On Demand

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Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery

Micromachines ◽

10.3390/mi12080975 ◽

2021 ◽

Vol 12 (8) ◽

pp. 975

Author(s):

Shahrukh Zaman Akash ◽

Farjana Yesmin Lucky ◽

Murad Hossain ◽

Asim Kumar Bepari ◽

G. M. Sayedur Rahman ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Drug Carriers ◽

Delivery Systems ◽

Burst Release ◽

Therapeutic Effects ◽

Microbial Infection ◽

Temperature Responsive ◽

On Demand

The development of externally controlled drug delivery systems that can rapidly trigger drug release is widely expected to change the landscape of future drug carriers. In this study, a drug delivery system was developed for on-demand therapeutic effects. The thermoresponsive paraffin film can be loaded on the basis of therapeutic need, including local anesthetic (lidocaine) or topical antibiotic (neomycin), controlled remotely by a portable mini-heater. The application of mild temperature (45 °C) to the drug-loaded paraffin film allowed a rapid stimulus response within a short time (5 min). This system exploits regular drug release and the rapid generation of mild heat to trigger a burst release of 80% within 6 h of any locally administered drug. The in vitro drug release studies and in vivo therapeutic activity were observed for local anesthesia and wound healing using a neomycin-loaded film. The studies demonstrated on-demand drug release with minimized inflammation and microbial infection. This temperature-responsive drug-loaded film can be triggered remotely to provide flexible control of dose magnitude and timing. Our preclinical studies on these remotely adjustable drug delivery systems can significantly improve patient compliance and medical practice.

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