Increased risk of craniosynostosis with maternal cigarette smoking during pregnancy

Teratology ◽  
1994 ◽  
Vol 50 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Beth W. Alderman ◽  
Cynthia M. Bradley ◽  
Carol Greene ◽  
Sandra K. Fernbach ◽  
Anna E. Barón
Keyword(s):  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Increased Risk

scholarly journals The epigenetics of maternal cigarette smoking during pregnancy and effects on child development

2012 ◽  
Vol 24 (4) ◽  
pp. 1377-1390 ◽  
Author(s):  
Valerie S. Knopik ◽  
Matthew A. Maccani ◽  
Sarah Francazio ◽  
John E. McGeary
Keyword(s):  
Cigarette Smoking ◽  
Fetal Growth ◽  
Growth And Development ◽  
Well Being ◽  
In Utero ◽  
Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Increased Risk ◽  
And Behavior

AbstractThe period of in utero development is one of the most critical windows during which adverse intrauterine conditions and exposures can influence the growth and development of the fetus as well as the child's future postnatal health and behavior. Maternal cigarette smoking during pregnancy remains a relatively common but nonetheless hazardous in utero exposure. Previous studies have associated prenatal smoke exposure with reduced birth weight, poor developmental and psychological outcomes, and increased risk for diseases and behavioral disorders later in life. Researchers are now learning that many of the mechanisms whereby maternal smoke exposure may affect key pathways crucial for proper fetal growth and development are epigenetic in nature. Maternal cigarette smoking during pregnancy has been associated with altered DNA methylation and dysregulated expression of microRNA, but a deeper understanding of the epigenetics of maternal cigarette smoking during pregnancy as well as how these epigenetic changes may affect later health and behavior remain to be elucidated. This article seeks to explore many of the previously described epigenetic alterations associated with maternal cigarette smoking during pregnancy and assess how such changes may have consequences for both fetal growth and development, as well as later child health, behavior, and well-being. We also outline future directions for this new and exciting field of research.

Intellectual Impairment in Children of Women Who Smoke Cigarettes During Pregnancy

PEDIATRICS ◽  
1994 ◽  
Vol 93 (2) ◽  
pp. 221-227 ◽  
Author(s):  
David L. Olds ◽  
Charles R. Henderson ◽  
Robert Tatelbaum
Keyword(s):  
New York ◽  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Upstate New York ◽  
Wide Range ◽  
Neurodevelopmental Impairment ◽  
The Relationship ◽  
Additional Reason

Objective. To examine the relationship between maternal cigarette smoking during pregnancy and children's intellectual functioning during the first 4 years of life. Design. Prospective follow-up of participants in a randomized trial of pregnancy and infancy nurse home visitation. Setting. Semirural community in Upstate New York. Participants. 400 families in which the mothers registered before the 30th week of pregnancy and had no previous live births. Eighty-five percent of the mothers were either teenagers (<19 years at registration), unmarried, or poor. Analysis limited to whites who comprised 89% of the sample. Main results. Children in the comparison group whose mothers smoked 10 or more cigarettes per day during pregnancy had Stanford-Binet scores at 3 and 4 years of age that were 4.35 (95% CI: 0.02, 8.68) points lower (after controlling for a wide range of variables) than their counterparts whose mothers did not smoke during pregnancy. Conclusions. The results of this study add to the increasingly consistent evidence that maternal cigarette smoking during pregnancy poses a unique risk for neurodevelopmental impairment among children and provide an additional reason for pregnant women not to smoke cigarettes.

scholarly journals Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife

Epigenetics ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Parisa Tehranifar ◽  
Hui-Chen Wu ◽  
Jasmine A. McDonald ◽  
Farzana Jasmine ◽  
Regina M. Santella ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking

Smoking during Pregnancy and Adverse Birth and Maternal Outcomes in California, 2007 to 2016

2019 ◽  
Vol 37 (13) ◽  
pp. 1364-1376
Author(s):  
Anura W.G. Ratnasiri ◽  
Lauren Gordon ◽  
Ronald A. Dieckmann ◽  
Henry C. Lee ◽  
Steven S. Parry ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
First Trimester ◽  
Population Based ◽  
Maternal Outcomes ◽  
Smoking During Pregnancy ◽  
Maternal Risk ◽  
Maternal Cigarette Smoking ◽  
Increased Risk

Abstract Objective This study aimed to determine associations between maternal cigarette smoking and adverse birth and maternal outcomes. Study Design This is a 10-year population-based retrospective cohort study including 4,971,896 resident births in California. Pregnancy outcomes of maternal smokers were compared with those of nonsmokers. The outcomes of women who stopped smoking before or during various stages of pregnancy were also investigated. Results Infants of women who smoked during pregnancy were twice as likely to have low birth weight (LBW) and be small for gestational age (SGA), 57% more likely to have very LBW (VLBW) or be a preterm birth (PTB), and 59% more likely to have a very PTB compared with infants of nonsmokers. During the study period, a significant widening of gaps developed in both rates of LBW and PTB and the percentage of SGA between infants of maternal smokers and nonsmokers. Conclusion Smoking during pregnancy is associated with a significantly increased risk of adverse birth and maternal outcomes, and differences in rates of LBW, PTB, and SGA between infants of maternal smokers and nonsmokers increased during this period. Stopping smoking before pregnancy or even during the first trimester significantly decreased the infant risks of LBW, PTB, SGA, and the maternal risk for cesarean delivery.

scholarly journals Nicotine and metabolites in meconium as evidence of maternal cigarette smoking during pregnancy and predictors of neonatal growth deficits

2010 ◽  
Vol 12 (6) ◽  
pp. 658-664 ◽  
Author(s):  
T. R. Gray ◽  
R. D. Eiden ◽  
K. E. Leonard ◽  
G. Connors ◽  
S. Shisler ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Neonatal Growth

scholarly journals Maternal Cigarette Smoking during Pregnancy and Risk of Oral Clefts in Newborns

1999 ◽  
Vol 150 (7) ◽  
pp. 683-694 ◽  
Author(s):  
S. Lieff ◽  
A. F. Olshan ◽  
M. Werler ◽  
R. P. Strauss ◽  
J. Smith ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Oral Clefts ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking

scholarly journals Maternal cigarette smoking during pregnancy and pubertal development in sons. A follow-up study of a birth cohort

Andrology ◽  
2013 ◽  
Vol 1 (2) ◽  
pp. 348-355 ◽  
Author(s):  
L. B. Håkonsen ◽  
J. Olsen ◽  
H. Støvring ◽  
A. Ernst ◽  
A. M. Thulstrup ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Birth Cohort ◽  
Pubertal Development ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Follow Up Study
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