Analysis of Sequence Requirements for Biological Activity of Cyanovirin-N, a Potent HIV(Human Immunodeficiency Virus)-Inactivating Protein

1997 ◽  
Vol 238 (1) ◽  
pp. 218-222 ◽  
Author(s):  
Toshiyuki Mori ◽  
Robert H. Shoemaker ◽  
Robert J. Gulakowski ◽  
Benjamin L. Krepps ◽  
James B. McMahon ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Biological Activity ◽  
Immunodeficiency Virus ◽  
Sequence Requirements

scholarly journals MAJOR BIOACTIVE TRITERPENOIDS FROM GANODERMA SPECIES AND THEIR THERAPEUTIC ACTIVITY: A REVIEW

2019 ◽  
pp. 22-30 ◽  
Author(s):  
ZAHOOR AHMAD BHAT Bhat ◽  
ABDUL HAMID WANI ◽  
MOHD YAQUB BHAT ◽  
ABDUL RASHID MALIK
Keyword(s):  
Human Immunodeficiency Virus ◽  
Biological Activity ◽  
Chinese Medicine ◽  
Ganoderma Lucidum ◽  
Therapeutic Effects ◽  
High Grade ◽  
Therapeutic Activity ◽  
Immunodeficiency Virus ◽  
Medicinal Properties ◽  
Anti Inflammation

Ganoderma a traditional Chinese medicine popularly used for complementary cancer therapy and longevity for centuries. The vast amount of study has been performed on the medicinal properties of Ganoderma lucidum. G. lucidum contains various compounds with a high grade of biological activity, which increase the immunity. Several of these substances belong to the triterpenoids and polysaccharides. Proteins, sterols, phenols, lipids, etc., are also present. Ganoderma triterpenes are important secondary metabolites of G. lucidum. Ganoderma triterpenes are limestone-tetracyclic terpenes which have been reported to possess antioxidant, antitumor, anti-human immunodeficiency virus, anticancer, anti-inflammation, cytotoxic, hepatoprotective, and neuroprotective activities. This review deals with most important triterpenes isolated from Ganoderma and their therapeutic effects.

scholarly journals Lack of Effect of Cytoplasmic Tail Truncations on Human Immunodeficiency Virus Type 2 ROD Env Particle Release Activity

1999 ◽  
Vol 73 (1) ◽  
pp. 778-782 ◽  
Author(s):  
Stephan P. Bour ◽  
Claudia Aberham ◽  
Christèle Perrin ◽  
Klaus Strebel
Keyword(s):  
Human Immunodeficiency Virus ◽  
Biological Activity ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Amino Acid Level ◽  
Cytoplasmic Tail ◽  
Site Directed Mutagenesis ◽  
Particle Release ◽  
Immunodeficiency Virus

ABSTRACT In addition to its role in receptor binding, the envelope glycoprotein of certain human immunodeficiency virus type 2 (HIV-2) isolates, including ROD10, exhibits a biological activity that enhances the release of HIV-2, HIV-1, and simian immunodeficiency virus particles from infected cells. The present study aims at better defining the functional domains involved in this biological activity. To this end, we have characterized the envelope protein of the ROD14 isolate of HIV-2, which, despite 95% homology with the ROD10 envelope at the amino acid level, is unable to enhance viral particle release. Site-directed mutagenesis showed that the presence of a truncation in the cytoplasmic tail of the ROD14 envelope was not responsible for the lack of activity, as previously reported for the HIV-2 ST isolate (G. D. Ritter, Jr., G. Yamshchikov, S. J. Cohen, and M. J. Mulligan, J. Virol. 70:2669–2673, 1996). Similarly, several modifications of the length of the ROD10 envelope cytoplasmic tail did not impair its ability to enhance particle release, suggesting that, in the case of the HIV-2 ROD isolate, particle release activity is not regulated by the length of the cytoplasmic tail.

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