Regulatory Role of Transforming Growth Factor-β, Bone Morphogenetic Protein-2, and Protein-4 on Gene Expression of Extracellular Matrix Proteins and Differentiation of Dental Pulp Cells

1994 ◽  
Vol 162 (1) ◽  
pp. 18-28 ◽  
Author(s):  
Misako Nakashima ◽  
Hisashi Nagasawa ◽  
Yoshihiko Yamada ◽  
A.Hari Reddi
Keyword(s):  
Gene Expression ◽  
Dental Pulp ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Matrix Proteins ◽  
Bone Morphogenetic Protein 2 ◽  
Dental Pulp Cells ◽  
Morphogenetic Protein ◽  
Pulp Cells

Role of SIRT1 in Heat Stress- and Lipopolysaccharide-induced Immune and Defense Gene Expression in Human Dental Pulp Cells

2011 ◽  
Vol 37 (11) ◽  
pp. 1525-1530 ◽  
Author(s):  
Sang-Im Lee ◽  
Kyung-San Min ◽  
Won-Jung Bae ◽  
Young-Man Lee ◽  
So-Youn Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Stress ◽  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Defense Gene Expression ◽  
Defense Gene ◽  
Human Dental Pulp Cells ◽  
Human Dental Pulp ◽  
Pulp Cells

scholarly journals Characterization of Living Dental Pulp Cells in Direct Contact with Mineral Trioxide Aggregate

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2336
Author(s):  
Tamaki Hattori-Sanuki ◽  
Takeo Karakida ◽  
Risako Chiba-Ohkuma ◽  
Yasuo Miake ◽  
Ryuji Yamamoto ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Dental Pulp ◽  
Direct Contact ◽  
Transforming Growth Factor ◽  
Mineral Trioxide Aggregate ◽  
Dental Pulp Cells ◽  
Differentiation Markers ◽  
Morphogenetic Protein ◽  
Cell Substrate ◽  
Pulp Cells

Mineral trioxide aggregate (MTA) was introduced as a material for dental endodontic regenerative therapy. Here, we show the dynamics of living dental pulp cells in direct contact with an MTA disk. A red fluorescence protein (DsRed) was introduced into immortalized porcine dental pulp cells (PPU7) and cloned. DsRed-PPU7 cells were cultured on the MTA disk and cell proliferation, chemotaxis, the effects of growth factors and the gene expression of cells were investigated at the biological, histomorphological and genetic cell levels. Mineralized precipitates formed in the DsRed-PPU7 cells were characterized with crystal structural analysis. DsRed-PPU7 cells proliferated in the central part of the MTA disk until Day 6 and displayed a tendency to move to the outer circumference. Both transforming growth factor beta and bone morphogenetic protein promoted the proliferation and movement of DsRed-PPU7 cells and also enhanced the expression levels of odontoblastic gene differentiation markers. Mineralized precipitates formed in DsRed-PPU7 were composed of calcium and phosphate but its crystals were different in each position. Our investigation showed that DsRed-PPU7 cells in direct contact with the MTA disk could differentiate into odontoblasts by controlling cell–cell and cell–substrate interactions depending on cell adhesion and the surrounding environment of the MTA.

scholarly journals Transforming growth factor-β-induced gene product-h3 inhibits odontoblastic differentiation of dental pulp cells

2017 ◽  
Vol 78 ◽  
pp. 135-143 ◽  
Author(s):  
Suguru Serita ◽  
Atsushi Tomokiyo ◽  
Daigaku Hasegawa ◽  
Sayuri Hamano ◽  
Hideki Sugii ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Product ◽  
Dental Pulp ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Dental Pulp Cells ◽  
Odontoblastic Differentiation ◽  
Pulp Cells
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