scholarly journals Perturbing Nuclear Transport in Drosophila Eye Imaginal Discs Causes Specific Cell Adhesion and Axon Guidance Defects

2001 ◽  
Vol 240 (2) ◽  
pp. 315-325 ◽  
Author(s):  
Justin P. Kumar ◽  
Gavin S. Wilkie ◽  
Hildegard Tekotte ◽  
Kevin Moses ◽  
Ilan Davis
Keyword(s):  
Cell Adhesion ◽  
Axon Guidance ◽  
Nuclear Transport ◽  
Imaginal Discs ◽  
Specific Cell ◽  
Drosophila Eye

scholarly journals Glycan-to-Glycan Binding: Molecular Recognition through Polyvalent Interactions Mediates Specific Cell Adhesion

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 397
Author(s):  
Gradimir Misevic ◽  
Emanuela Garbarino
Keyword(s):  
Cell Adhesion ◽  
Plasma Membranes ◽  
Specific Cell ◽  
Cellular Interactions ◽  
New Paradigm ◽  
Tumor Cell Adhesion ◽  
Self Recognition ◽  
Structural And Functional Properties ◽  
Low Valent

Glycan-to-glycan binding was shown by biochemical and biophysical measurements to mediate xenogeneic self-recognition and adhesion in sponges, stage-specific cell compaction in mice embryos, and in vitro tumor cell adhesion in mammals. This intermolecular recognition process is accepted as the new paradigm accompanying high-affinity and low valent protein-to-protein and protein-to-glycan binding in cellular interactions. Glycan structures in sponges have novel species-specific sequences. Their common features are the large size >100 kD, polyvalency >100 repeats of the specific self-binding oligosaccharide, the presence of fucose, and sulfated and/or pyruvylated hexoses. These structural and functional properties, different from glycosaminoglycans, inspired their classification under the glyconectin name. The molecular mechanism underlying homophilic glyconectin-to-glyconectin binding relies on highly polyvalent, strong, and structure-specific interactions of small oligosaccharide motifs, possessing ultra-weak self-binding strength and affinity. Glyconectin localization at the glycocalyx outermost cell surface layer suggests their role in the initial recognition and adhesion event during the complex and multistep process. In mammals, Lex-to-Lex homophilic binding is structure-specific and has ultra-weak affinity. Cell adhesion is achieved through highly polyvalent interactions, enabled by clustering of small low valent structure in plasma membranes.

scholarly journals Carbohydrate-specific cell adhesion is mediated by immobilized glycolipids.

1983 ◽  
Vol 258 (2) ◽  
pp. 1180-1188 ◽  
Author(s):  
C C Blackburn ◽  
R L Schnaar
Keyword(s):  
Cell Adhesion ◽  
Specific Cell

scholarly journals Notch Controls Cell Adhesion in the Drosophila Eye

PLoS Genetics ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. e1004087 ◽  
Author(s):  
Sujin Bao
Keyword(s):  
Cell Adhesion ◽  
Drosophila Eye

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation

Development ◽  
1994 ◽  
Vol 120 (3) ◽  
pp. 535-544 ◽  
Author(s):  
S.A. Speicher ◽  
U. Thomas ◽  
U. Hinz ◽  
E. Knust
Keyword(s):  
Cell Proliferation ◽  
Transmembrane Protein ◽  
Ectopic Expression ◽  
Imaginal Discs ◽  
Specific Cell ◽  
Loss Of Function ◽  
Severe Reduction ◽  
Homozygous Mutant ◽  
Wing Imaginal Discs ◽  
Larval Lethality

The Drosophila gene Serrate encodes a transmembrane protein with 14 EGF-like repeats in its extracellular domain. Here we show that loss-of-function mutations in this gene lead to larval lethality. Homozygous mutant larvae fail to differentiate the anterior spiracles, exhibit poorly developed mouth-hooks and show a severe reduction in the size of the wing and haltere primordia, which is not due to cell death. The few homozygous mutant escapers that pupariate develop into pharate adults that almost completely lack wings and halteres. Clonal analysis in the adult epidermis demonstrates a requirement for Serrate during wing and haltere development. Targeted ectopic expression of Serrate in the imaginal discs using the yeast transcriptional activator Gal4 results in regionally restricted induction of cell proliferation, e.g. the ventral tissues in the case of the wings and halteres. The results suggest that the wild-type function of Serrate is required for the control of position-specific cell proliferation during development of meso- and metathoracic dorsal discs, which in turn exerts a direct effect on morphogenesis.

Cadherin-Mediated Specific Cell Adhesion and Animal Morphogenesis

2007 ◽  
pp. 243-254
Author(s):  
Masatoshi Takeichi ◽  
Kohei Hatta ◽  
Akinao Nose ◽  
Akira Nagafuchi ◽  
Mayumi Matsunaga
Keyword(s):  
Cell Adhesion ◽  
Specific Cell

Folate receptor-specific cell-cell adhesion by using a folate-modified peptide-based anchor

2019 ◽  
Vol 30 (11) ◽  
pp. 983-993
Author(s):  
Hiroko Nagai ◽  
Wataru Hatanaka ◽  
Masayoshi Matsuda ◽  
Akihiro Kishimura ◽  
Yoshiki Katayama ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Folate Receptor ◽  
Specific Cell ◽  
Cell Cell

Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789

2001 ◽  
Vol 50 (11) ◽  
pp. 544-551 ◽  
Author(s):  
S. Ohta ◽  
Y. Inujima ◽  
M. Abe ◽  
Y. Uosaki ◽  
S. Sato ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cell Adhesion ◽  
Low Molecular Weight ◽  
Specific Cell

scholarly journals Potency of Fish Collagen as a Scaffold for Regenerative Medicine

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shizuka Yamada ◽  
Kohei Yamamoto ◽  
Takeshi Ikeda ◽  
Kajiro Yanagiguchi ◽  
Yoshihiko Hayashi
Keyword(s):  
Tissue Engineering ◽  
Cell Adhesion ◽  
Regenerative Medicine ◽  
Collagen Molecule ◽  
Specific Cell ◽  
Natural Polymers ◽  
Collagen Scaffolds ◽  
Rgd Motif ◽  
Cell Functions ◽  
Fish Collagen

Cells, growth factors, and scaffold are the crucial factors for tissue engineering. Recently, scaffolds consisting of natural polymers, such as collagen and gelatin, bioabsorbable synthetic polymers, such as polylactic acid and polyglycolic acid, and inorganic materials, such as hydroxyapatite, as well as composite materials have been rapidly developed. In particular, collagen is the most promising material for tissue engineering due to its biocompatibility and biodegradability. Collagen contains specific cell adhesion domains, including the arginine-glycine-aspartic acid (RGD) motif. After the integrin receptor on the cell surface binds to the RGD motif on the collagen molecule, cell adhesion is actively induced. This interaction contributes to the promotion of cell growth and differentiation and the regulation of various cell functions. However, it is difficult to use a pure collagen scaffold as a tissue engineering material due to its low mechanical strength. In order to make up for this disadvantage, collagen scaffolds are often modified using a cross-linker, such as gamma irradiation and carbodiimide. Taking into account the possibility of zoonosis, a variety of recent reports have been documented using fish collagen scaffolds. We herein review the potency of fish collagen scaffolds as well as associated problems to be addressed for use in regenerative medicine.

SPECIFIC CELL ADHESION ONTO URIDINE-CONTAINING GLYCOPOLYMER

2002 ◽  
Author(s):  
Kenichi Hatanaka ◽  
Yoshihide Yachi ◽  
Maria Carmelita Kasuya ◽  
Sae Matsunaga ◽  
Megumi Kunou
Keyword(s):  
Cell Adhesion ◽  
Specific Cell
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