Lack of Effects of Transforming Growth Factor-α Gene Knockout on Peripheral Nerve Regeneration May Result from Compensatory Mechanisms

2001 ◽  
Vol 172 (1) ◽  
pp. 182-188 ◽  
Author(s):  
Cory J. Xian ◽  
Li Li ◽  
Yan-Shen Deng ◽  
Su-Ping Zhao ◽  
Xin-Fu Zhou
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Transforming Growth Factor ◽  
Gene Knockout ◽  
Peripheral Nerve Regeneration ◽  
Compensatory Mechanisms ◽  
Transforming Growth Factor Α ◽  
Factor Α

Improved Peripheral Nerve Regeneration in Streptozotocin-Induced Diabetic Rats by Oral Lumbrokinase

2015 ◽  
Vol 43 (02) ◽  
pp. 215-230 ◽  
Author(s):  
Han-Chung Lee ◽  
Yuan-Man Hsu ◽  
Chin-Chuan Tsai ◽  
Cherng-Jyh Ke ◽  
Chun-Hsu Yao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Transforming Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Interleukin 1 ◽  
Diabetic Rats ◽  
Therapeutic Effects ◽  
Nerve Lesion

We assessed the therapeutic effects of lumbrokinase, a group of enzymes extracted from the earthworm, on peripheral-nerve regeneration using well-defined sciatic nerve lesion paradigms in diabetic rats induced by the injection of streptozotocin (STZ). We found that lumbrokinase therapy could improve the rats' circulatory blood flow and promote the regeneration of axons in a silicone rubber conduit after nerve transection. Lumbrokinase treatment could also improve the neuromuscular functions with better nerve conductive performances. Immunohistochemical staining showed that lumbrokinase could dramatically promote calcitonin gene-related peptide (CGRP) expression in the lamina I–II regions in the dorsal horn ipsilateral to the injury and cause a marked increase in the number of macrophages recruited within the distal nerve stumps. In addition, the lumbrokinase could stimulate the secretion of interleukin-1 (IL-1), nerve growth factor (NGF), platelet-derived growth factor (PDGF), and transforming growth factor-β (TGF-β) in dissected diabetic sciatic nerve segments. In conclusion, the administration of lumbrokinase after nerve repair surgery in diabetic rats was found to have remarkable effects on promoting peripheral nerve regeneration and functional recovery.

scholarly journals Transforming growth factor-α in the mammalian brain

1989 ◽  
Vol 264 (7) ◽  
pp. 3880-3883
Author(s):  
J E Kudlow ◽  
A W Leung ◽  
M S Kobrin ◽  
A J Paterson ◽  
S L Asa
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Mammalian Brain ◽  
Transforming Growth Factor Α ◽  
Factor Α

scholarly journals Mammary Carcinogenesis Is Preceded by Altered Epithelial Cell Turnover in Transforming Growth Factor-α and c-myc Transgenic Mice

2006 ◽  
Vol 169 (5) ◽  
pp. 1821-1832 ◽  
Author(s):  
Teresa A. Rose-Hellekant ◽  
Kristin M. Wentworth ◽  
Sarah Nikolai ◽  
Donald W. Kundel ◽  
Eric P. Sandgren
Keyword(s):  
Growth Factor ◽  
Epithelial Cell ◽  
Transgenic Mice ◽  
Transforming Growth Factor ◽  
Mammary Carcinogenesis ◽  
Cell Turnover ◽  
Transforming Growth Factor Α ◽  
Factor Α
Sign in / Sign up

Export Citation Format

Share Document