Interference effects on vortex-induced vibrations of two side-by-side elastic cylinders, fixed at both ends (with no deflection and displacement) in a cross-flow, were experimentally investigated. The dynamic responses of the cylinders were measured using two fiber-optic Bragg grating (FBG) sensors. Simultaneously, a single hot wire was used to measure the velocity in the wake. It has been previously observed that violent resonance occurs when transverse cylinder spacing ratio, T/d, is either large (>2.0) or small (<1.2), but not for intermediate cylinder spacing, i.e., T/d=1.2∼2.0. This work aims to improve the understanding of the physics behind this observation, and mostly focuses on the fluid-structure interaction in the flow regime of intermediate cylinder spacing. It is well known that in this flow regime the fluid dynamics around one cylinder is totally different from that around the other; the vortical structures are characterized by different dominant frequencies, i.e., about 0.1 and 0.3 (normalized), respectively. The present data indicates that the vortical structures at these frequencies are either weak or different in the formation process from the case of T/d>2.0 or T/d<1.2, thus resulting in a weak excitation and subsequently an absence of violent resonance. The interrelationship between the vortical structures generated by the two cylinders is also investigated and interpreted in terms of different vortex generation mechanisms. The different fluid dynamics around each cylinder is further found to be responsible for a deviation between the natural frequencies of the combined fluid-cylinder system associated with each cylinder.