A mutation in the C-terminal domain of the RNA polymerase alpha subunit that destabilizes the open complexes formed at the phage φ29 late A3 promoter11Edited by I. B. Holland

2001 ◽  
Vol 307 (2) ◽  
pp. 487-497 ◽  
Author(s):  
Belén Calles ◽  
Marı́a Monsalve ◽  
Fernando Rojo ◽  
Margarita Salas
Keyword(s):  
Rna Polymerase ◽  
Alpha Subunit ◽  
Terminal Domain

scholarly journals Overexpression of the RNA Polymerase Alpha Subunit Reduces Transcription of Bvg-Activated Virulence Genes inBordetella pertussis

2000 ◽  
Vol 182 (2) ◽  
pp. 529-531 ◽  
Author(s):  
Nicholas H. Carbonetti ◽  
Alla Romashko ◽  
Teresa J. Irish
Keyword(s):  
Rna Polymerase ◽  
Virulence Factor ◽  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Virulence Genes ◽  
Transcriptional Activator ◽  
Alpha Subunit ◽  
Terminal Domain

ABSTRACT Overexpression of the RNA polymerase alpha subunit inBordetella pertussis reduces expression of the virulence factor pertussis toxin. Here we show that this reduction is at the level of transcription, is reversed by overexpression of the transcriptional activator BvgA, and is dependent on the C-terminal domain of alpha.

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