Patients receiving palliative care often experience severe psychosocial distress, which may due to the perception of the situation, the community resources and support, educational level, comorbidities, coping skills, and socioeconomic status. However, the distress can be reduced by communication between patients, caregivers, and health care providers. Studies have shown that family conferences can be a safe and well-accepted means for communication between patients, caregivers, and health care providers in the palliative care setting. This chapter highlights key topics regarding the family conference and facilitation of patient–clinician communication in palliative care. The topics covered in this chapter include (a) key components of a family conference (e.g., the importance of listening, therapeutic communication, and missed opportunities), (b) proactive communication strategies in the intensive care unit, (c) use of patient navigators and communication facilitators to reduce family distress, and (d) the impact of advance care planning on end-of-life decision-making regarding resuscitation.