Effect of biodegradable polymer poly (L-lactic acid) on the cellular function of human astrocytes

Author(s):  
Naohito Nakamura ◽  
Toshie Tsuchiya
2021 ◽  
pp. 40-43
Author(s):  
Дмитрий Михайлович Мяленко

Вопросы защиты окружающей среды и улучшения экологической обстановки приобретают глобальный характер. Количество производимых в России и зарубежных странах синтетических полимерных материалов постоянно увеличивается, что заставляет задуматься о подходах к разработке современных биоразлагаемых полимерных материалов из полностью возобновляемого растительного сырья. Один из таких материалов - это линейный алифатический биополимер, полученный путем гидролиза молочной кислоты: полилактид (PLA). В данной статье представлены результаты исследований способности к биоразложению полимерных материалов на основе PLA при их компостировании в течение 3 мес. The issues of environmental protection and improvement of the ecological situation are becoming global in nature. The number of synthetic polymeric materials produced from Russia and foreign countries is constantly increasing, which makes us think about approaches to the development of modern biodegradable polymeric materials from completely renewable plant materials. One such material is a linear aliphatic biopolymer made by hydrolysis of lactic acid: polylactide (PLA). This article presents the results of studies on the biodegradability of PLA-based polymeric materials when composted for 3 months.


2016 ◽  
Vol 19 (4) ◽  
pp. 58-65
Author(s):  
Ha Thi Thai La

In this research, the PLA-diol were synthesized from lactic acid (LA) and 1.4 butanediols (BD) with a tin octoate Sn(Oct)2 catalyst at a temperature of 180 °C and the pressure 5 mmHg. The structure and properties of PLA-diol are analyzed by the following methods: GPC, 1H-NMR and DSC. As a result, with the change in the content of Sn (Oct)2 from 0.1 to 1.0%, the molecular weight Mn of PLA - diol increased gradually from 4.119,2 to 7.359,6 g / mol . In addition, the BD content increased from 2.0% to 5.0%, the average molecular weight of the product decreased gradually from 7.536,9 g / mol to 4.735 g / mol, respectively. This change will affect the ability to use PLA-diol in the next denaturation research to apply in the field of biodegradable polymer such as copolymer with polyurethane, copolymer with polyethylene glycol diacid, or chain extension with other polymer in a chain reaction,...


2006 ◽  
Vol 25 (5) ◽  
pp. 628-634 ◽  
Author(s):  
Kazuo Arakawa ◽  
Toshio Mada ◽  
Sang-Dae Park ◽  
Mitsugu Todo

Author(s):  
Mihir Sheth ◽  
R. Ananda Kumar ◽  
Vipul Dav� ◽  
Richard A. Gross ◽  
Stephen P. McCarthy

2014 ◽  
Vol 56 ◽  
pp. 648-658 ◽  
Author(s):  
Sommai Pivsa-Art ◽  
Nichanan Phansroy ◽  
Wiranphat Thodsaratpiyakul ◽  
Chatchavan Sukkaew ◽  
Weraporn Pivsa-Art ◽  
...  

2000 ◽  
Vol 40 (12) ◽  
pp. 2539-2550 ◽  
Author(s):  
Jun Wuk Park ◽  
Seung Soon Im ◽  
Soo Hyun Kim ◽  
Young Ha Kim

2015 ◽  
Vol 3 (2) ◽  
pp. 100-109
Author(s):  
Sommai Pivsa-Art ◽  
Sumonman Niamlang ◽  
Weraporn Pivsa-Art ◽  
Nutchapon Santipatee ◽  
Tossamon Wongborh ◽  
...  

1999 ◽  
Vol 43 (3) ◽  
pp. 714-716 ◽  
Author(s):  
Kyriaki Kanellakopoulou ◽  
Maria Kolia ◽  
Antonios Anastassiadis ◽  
Themistoklis Korakis ◽  
Evangelos J. Giamarellos-Bourboulis ◽  
...  

ABSTRACT A biodegradable polymer of dl-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.


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