Melanoblasts as Multipotent Cells in Murine Skin

2018 ◽  
pp. 257-266
Author(s):  
Tsutomu Motohashi ◽  
Takahiro Kunisada
Keyword(s):  
Multipotent Cells

scholarly journals New Sources, Differentiation, and Therapeutic Uses of Mesenchymal Stem Cells

2021 ◽  
Vol 22 (10) ◽  
pp. 5288
Author(s):  
Saeyoung Park ◽  
Sung-Chul Jung
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissues ◽  
Therapeutic Uses ◽  
Multipotent Cells

Mesenchymal stem cells (MSCs) are multipotent cells derived from various tissues including bone marrow and adipose tissues [...]

Adipocyte differentiation of multipotent cells established from human adipose tissue

2004 ◽  
Vol 315 (2) ◽  
pp. 255-263 ◽  
Author(s):  
Anne-Marie Rodriguez ◽  
Christian Elabd ◽  
Frédéric Delteil ◽  
Julien Astier ◽  
Cécile Vernochet ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Adipocyte Differentiation ◽  
Human Adipose Tissue ◽  
Multipotent Cells

The neural crest population responding to endothelin-3 in vitro includes multipotent cells

1997 ◽  
Vol 110 (14) ◽  
pp. 1673-1682 ◽  
Author(s):  
J.G. Stone ◽  
L.I. Spirling ◽  
M.K. Richardson
Keyword(s):  
Neural Crest ◽  
Schwann Cells ◽  
Cell Types ◽  
Developmental Potential ◽  
Colony Assay ◽  
Cellular Targets ◽  
Multipotent Cells ◽  
Endothelin 3

The peptide endothelin 3 (EDN3) is essential for normal neural crest development in vivo, and is a potent mitogen for quail truncal crest cells in vitro. It is not known which subpopulations of crest cells are targets for this response, although it has been suggested that EDN3 is selective for melanoblasts. In the absence of cell markers for different precursor types in the quail crest, we have characterised EDN3-responsive cell types using in vitro colony assay and clonal analysis. Colonies were analysed for the presence of Schwann cells, melanocytes, adrenergic cells or sensory-like cells. We provide for the first time a description of the temporal pattern of lineage segregation in neural crest cultures. In the absence of exogenous EDN3, crest cells proliferate and then differentiate. Colony assay indicates that in these differentiated cultures few undifferentiated precursors remain and there is a low replating efficiency. By contrast, in the presence of 100 ng/ml EDN3 differentiation is inhibited and most of the cells maintain the ability to give rise to mixed colonies and clones containing neural crest derivatives. A high replating efficiency is maintained. In secondary culture there was a progressive decline in the number of cell types per colony in control medium. This loss of developmental potential was not seen when exogenous EDN3 was present. Cell type analysis suggests two novel cellular targets for EDN3 under these conditions. Contrary to expectations, one is a multipotent precursor whose descendants include melanocytes, adrenergic cells and sensory-like cells; the other can give rise to melanocytes and Schwann cells. Our data do not support previous claims that the action of EDN3 in neural crest culture is selective for cells in the melanocyte lineage.

The fate of cells in the tailbud of Xenopus laevis

Development ◽  
2000 ◽  
Vol 127 (2) ◽  
pp. 255-267 ◽  
Author(s):  
R.L. Davis ◽  
M.W. Kirschner
Keyword(s):  
Xenopus Laevis ◽  
Small Groups ◽  
Neural Tube ◽  
Cell Types ◽  
Similar Distribution ◽  
Germ Layer ◽  
Cell Determination ◽  
Multipotent Cells ◽  
Axial Development

The vertebrate tailbud and trunk form very similar tissues. It has been a controversial question for decades whether cell determination in the developing tail proceeds as part of early axial development or whether it proceeds by a different mechanism. To examine this question more closely, we have used photoactivation of fluorescence to mark small neighborhoods of cells in the developing tailbud of Xenopus laevis. We show that, in one region of the tailbud, very small groups of adjacent cells can contribute progeny to the neural tube, notochord and somitic muscle, as well as other identified cell types within a single embryo. Groups averaging three adjacent cells at a later stage can contribute progeny with a similar distribution. Our data suggest that the tailbud contains multipotent cells that make very late germ-layer decisions.

scholarly journals Mesenchymal Stem Cells after Polytrauma: Actor and Target

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Markus Huber-Lang ◽  
Rebecca Wiegner ◽  
Lorenz Lampl ◽  
Rolf E. Brenner
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Healing Process ◽  
Severe Trauma ◽  
Signaling Mechanisms ◽  
Multipotent Cells ◽  
Proliferation And Differentiation ◽  
Tissue Trauma ◽  
Molecular Patterns ◽  
Severe Tissue

Mesenchymal stem cells (MSCs) are multipotent cells that are considered indispensable in regeneration processes after tissue trauma. MSCs are recruited to damaged areas via several chemoattractant pathways where they function as “actors” in the healing process by the secretion of manifold pro- and anti-inflammatory, antimicrobial, pro- and anticoagulatory, and trophic/angiogenic factors, but also by proliferation and differentiation into the required cells. On the other hand, MSCs represent “targets” during the pathophysiological conditions after severe trauma, when excessively generated inflammatory mediators, complement activation factors, and damage- and pathogen-associated molecular patterns challenge MSCs and alter their functionality. This in turn leads to complement opsonization, lysis, clearance by macrophages, and reduced migratory and regenerative abilities which culminate in impaired tissue repair. We summarize relevant cellular and signaling mechanisms and provide an up-to-date overview about promising future therapeutic MSC strategies in the context of severe tissue trauma.

Involvement of acetyl-CoA-producing enzymes in the deterioration of the functional potential of adipose-derived multipotent cells from subjects with metabolic syndrome

Metabolism ◽  
2018 ◽  
Vol 88 ◽  
pp. 12-21 ◽  
Author(s):  
Wilfredo Oliva-Olivera ◽  
Said Lhamyani ◽  
Leticia Coín-Aragüez ◽  
Juan Alcaide-Torres ◽  
Fernando Cardona ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Acetyl Coa ◽  
Functional Potential ◽  
Multipotent Cells

Common precursors for neural and mesectodermal derivatives in the cephalic neural crest

Development ◽  
1991 ◽  
Vol 112 (1) ◽  
pp. 301-305 ◽  
Author(s):  
A. Baroffio ◽  
E. Dupin ◽  
N.M. Le Douarin
Keyword(s):  
Neural Crest ◽  
Cell Types ◽  
Culture Conditions ◽  
Pigment Cells ◽  
Stem Cell Population ◽  
Multipotent Cells ◽  
Clonal Cultures ◽  
Vertebrate Embryos ◽  
Derivatives Of

The cephalic neural crest (NC) of vertebrate embryos yields a variety of cell types belonging to the neuronal, glial, melanocytic and mesectodermal lineages. Using clonal cultures of quail migrating cephalic NC cells, we demonstrated that neurons and glial cells of the peripheral nervous system can originate from the same progenitors as cartilage, one of the mesectodermal derivatives of the NC. Moreover, we obtained evidence that the migrating cephalic NC contains a few highly multipotent precursors that are common to neurons, glia, cartilage and pigment cells and which we interprete as representative of a stem cell population. In contrast, other NC cells, although provided with identical culture conditions, give rise to clones composed of only one or some of these cell types. These cells thus appear restricted in their developmental potentialities compared to multipotent cells. It is therefore proposed that, in vivo, the active proliferation of pluripotent NC cells during the migration process generates distinct subpopulations of cells that become progressively committed to different developmental fates.

scholarly journals Identification of two distinct pathways of human myelopoiesis

2019 ◽  
Vol 4 (35) ◽  
pp. eaau7148 ◽  
Author(s):  
Roy Drissen ◽  
Supat Thongjuea ◽  
Kim Theilgaard-Mönch ◽  
Claus Nerlov
Keyword(s):  
Mast Cell ◽  
Single Cell ◽  
Lineage Commitment ◽  
Cell Populations ◽  
Single Cell Level ◽  
Cell Level ◽  
Lymphoid Lineage ◽  
Myeloid Progenitor ◽  
Multipotent Cells ◽  
Cellular Pathways

Human myelopoiesis has been proposed to occur through oligopotent common myeloid progenitor (CMP) and lymphoid-primed multipotent progenitor (LMPP) populations. However, other studies have proposed direct commitment of multipotent cells to unilineage fates, without specific intermediary lineage cosegregation patterns. We here show that distinct human myeloid progenitor populations generate the neutrophil/monocyte and mast cell/basophil/eosinophil lineages as previously shown in mouse. Moreover, we find that neutrophil/monocyte potential selectively cosegregates with lymphoid lineage and mast cell/basophil/eosinophil potentials with megakaryocyte/erythroid potential early during lineage commitment. Furthermore, after this initial commitment step, mast cell/basophil/eosinophil and megakaryocyte/erythroid potentials colocalize at the single-cell level in restricted oligopotent progenitors. These results show that human myeloid lineages are generated through two distinct cellular pathways defined by complementary oligopotent cell populations.

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