Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry

2019 ◽  
pp. 55-78 ◽  
Author(s):  
Rick Reisdorph ◽  
Cole Michel ◽  
Kevin Quinn ◽  
Katrina Doenges ◽  
Nichole Reisdorph
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Metabolomics Analysis

High resolution ion mobility-mass spectrometry for separation and identification of isomeric lipids

The Analyst ◽  
2015 ◽  
Vol 140 (20) ◽  
pp. 6904-6911 ◽  
Author(s):  
M. Groessl ◽  
S. Graf ◽  
R. Knochenmuss
Keyword(s):  
Mass Spectrometry ◽  
Double Bond ◽  
High Resolution ◽  
Ion Mobility ◽  
Biological Samples ◽  
Drift Tube ◽  
Acyl Chain ◽  
Ion Mobility Mass Spectrometry

Separation and identification of isomeric species is a major challenge in lipidomics. Herein, we demonstrate that lipid isomers that differ only in position of the acyl chain, position of the double bond or double bond geometry can be distinguished using drift-tube ion mobility-mass spectrometry, even in complex biological samples.

scholarly journals Electron capture dissociation and drift tube ion mobility-mass spectrometry coupled with site directed mutations provide insights into the conformational diversity of a metamorphic protein

2015 ◽  
Vol 17 (16) ◽  
pp. 10538-10550 ◽  
Author(s):  
Sophie R. Harvey ◽  
Massimiliano Porrini ◽  
Robert C. Tyler ◽  
Cait E. MacPhee ◽  
Brian F. Volkman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Top Down ◽  
Conformational Diversity ◽  
Metamorphic Protein

Ion mobility mass spectrometry can be combined with data from top-down sequencing to discern adopted conformations of proteins in the absence of solvent.

Rapid Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum Using Liquid Chromatography/Drift Tube Ion Mobility-Mass Spectrometry

2019 ◽  
Vol 91 (21) ◽  
pp. 13555-13561 ◽  
Author(s):  
Nicholas R. Oranzi ◽  
Jiajun Lei ◽  
Robin H. J. Kemperman ◽  
Christopher D. Chouinard ◽  
Brett Holmquist ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Serum ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry

Petroleomics by ion mobility mass spectrometry: resolution and characterization of contaminants and additives in crude oils and petrofuels

2015 ◽  
Vol 7 (11) ◽  
pp. 4450-4463 ◽  
Author(s):  
Jandyson Machado Santos ◽  
Renan de S. Galaverna ◽  
Marcos A. Pudenzi ◽  
Eduardo M. Schmidt ◽  
Nathaniel L. Sanders ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Crude Oil ◽  
Ion Mobility ◽  
Drift Tube ◽  
Crude Oils ◽  
Ion Mobility Mass Spectrometry ◽  
Uniform Field ◽  
Field Drift

IM-MS, was performed in a new uniform-field drift tube, IM-QTOF instrument. It can resolve and characterize crude oil and its contaminants, as well as petrofuels and their additives.

Liquid chromatography–drift tube ion mobility–mass spectrometry as a new challenging tool for the separation and characterization of silymarin flavonolignans

2020 ◽  
Vol 412 (4) ◽  
pp. 819-832 ◽  
Author(s):  
Marie Fenclova ◽  
Milena Stranska-Zachariasova ◽  
Frantisek Benes ◽  
Alena Novakova ◽  
Petra Jonatova ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry

Separation of phosphorothioated oligonucleotide diastereomers using multiplexed drift tube ion mobility mass spectrometry

2021 ◽  
pp. 339297
Author(s):  
Alice Demelenne ◽  
Gwenael Nys ◽  
Cindy Nix ◽  
John C. Fjeldsted ◽  
Jacques Crommen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry

Effects of Drift Gas on Collision Cross Sections of a Protein Standard in Linear Drift Tube and Traveling Wave Ion Mobility Mass Spectrometry

2012 ◽  
Vol 84 (20) ◽  
pp. 8524-8531 ◽  
Author(s):  
Ewa Jurneczko ◽  
Jason Kalapothakis ◽  
Iain D. G. Campuzano ◽  
Michael Morris ◽  
Perdita E Barran
Keyword(s):  
Mass Spectrometry ◽  
Cross Sections ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Linear Drift ◽  
Collision Cross Sections ◽  
Traveling Wave Ion Mobility

scholarly journals Resolving Structural Isomers of Monosaccharide Methyl Glycosides Using Drift Tube and Traveling Wave Ion Mobility Mass Spectrometry

2012 ◽  
Vol 84 (7) ◽  
pp. 3231-3239 ◽  
Author(s):  
Hongli Li ◽  
Kevin Giles ◽  
Brad Bendiak ◽  
Kimberly Kaplan ◽  
William F. Siems ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Structural Isomers ◽  
Traveling Wave Ion Mobility
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