Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics

Author(s):  
Jerome Hochman ◽  
Tomi Sawyer ◽  
Ruchia Duggal
Religions ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 548
Author(s):  
Elliott Ingersoll ◽  
Sophia Elliott ◽  
Stephanie Drcar

UFGLI students comprise 34% of the students enrolled in four-year universities. Unlike some students, UFGLI students face internal and systemic barriers throughout their educational experience and their struggles are often dismissed and disregarded. Working and raising a family while taking courses, minimal support systems, and financial struggles require students to optimize their resources. We explore the issues of UFGLI students and the importance of their spiritual and religious supports using a literature review and a case study. Religious and spiritual identities are resources that should be explored and supported by staff at university counselling centers. Affirming UFGLI students’ religious and spiritual identities and understanding how religion and spirituality work in their lives can assist these students in their acclimation to and success at university.


AERA Open ◽  
2021 ◽  
Vol 7 ◽  
pp. 233285842110187
Author(s):  
Meredith R. Naughton

The COVID-19 (coronavirus disease–2019) pandemic disrupted the education of students across the globe in the spring of 2020. Students who were previously at most risk for falling behind their peers and through the cracks because of academic, financial, racial, and/or generational disadvantage faced a wide range of additional obstacles in the pursuit of their college goals. This qualitative study sought to uncover postsecondary advising implications for students through the perspectives of near-peer college advisers (n = 23) serving in high-need schools in two different states as intensive, in-person advising was forced to adapt to virtual formats. Two key thematic findings reveal that advisers faced new communication challenges and existing systemic barriers for marginalized students became even larger. For seniors who had not yet made final postsecondary decisions or who had remaining to-dos, the impact of school closures and distanced advising may have fatally widened existing cracks in the path to college.


2016 ◽  
Vol 375 (2) ◽  
pp. 375-383 ◽  
Author(s):  
Marc Krüger ◽  
Hubert Kalbacher ◽  
Panagiotis L. Kastritis ◽  
Joachim Bischof ◽  
Holger Barth ◽  
...  
Keyword(s):  

2021 ◽  
pp. 1709-1718
Author(s):  
Kathleen F. Mittendorf ◽  
Sarah Knerr ◽  
Tia L. Kauffman ◽  
Nangel M. Lindberg ◽  
Katherine P. Anderson ◽  
...  

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Monire Davoodi ◽  
Behnaz Dindamal ◽  
Hossein Dargahi ◽  
Farzad Faraji-Khiavi

Abstract Background More than three decades of research and study for overcoming the problem of “non-acceptance/non-compliance” of patients has neither resolved nor reduced the severity of this problem. This phenomenological study aimed to identify barriers of adherence to medical advice among type 2 diabetic patients. Methods This study was a qualitative research using phenomenology approach, and the data were analyzed using content analysis approach. Participants were 69 type 2 diabetic patients covered by the diabetes unit of West and East Community Health Centers of Ahvaz, Iran. The views and attitudes of patients about the barriers of adherence to medical advice were elicited by conducting 20–45 min sessions of semi-structured interviews. Data analysis was performed following Colaizzi’s seven-step method. Results Barriers of adherence to medical advice were classified into systemic and individual barriers. Individual barriers included 11 codes and 5 categories, and systemic barriers contained within 5 codes and 3 categories. Physiologic and physical factors, financial problems, occupational factors, attitudinal problems and lack of knowledge, and social and family problems were identified as individual barriers. Systemic barriers included inadequate publicizing and limited notification, inadequate equipment and facilities, and poor inter-sectional coordination. Conclusions Generally, problems stated by diabetic patients at the individual level can partly be solved by training patients and the people around them. However, as for the systemic problems, it seems that solving the barriers of adherence to medical advice requires coordination with other organizations as well as intersection coordination. Overall, these problems require not only comprehensive health service efforts, but also the support of policymakers to resolve barriers at infrastructure level.


2005 ◽  
Vol 58 (11) ◽  
pp. 778 ◽  
Author(s):  
Andrew B. Hughes ◽  
Brad E. Sleebs

N-Methyl β-amino acids are potentially useful amino acid derivatives for incorporation in lead peptide therapeutics. The syntheses of five such compounds are presented. Their synthesis via 6-oxazinanones was low yielding. Alternatively, reductive cleavage of a 5-oxazolidinone gave the N-methyl α-amino acid, which was then homologated via an Arndt–Eistert procedure in high yield to give the N-methyl β-amino acid.


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