Interface Hepatitis in primary billary cirrhosis prognostic marker and therapeutic target

2007 ◽  
pp. 66-74
Author(s):  
R. Poupon ◽  
L. Abenavoli ◽  
N. Rabahi ◽  
Y. Chretien ◽  
O. Chazoulleres ◽  
...  
Keyword(s):  
Prognostic Marker ◽  
Therapeutic Target

Multiple Metamorphoses of CD38 from Prognostic Marker to Disease Modifier to Therapeutic Target in Chronic Lymphocytic Leukemia

2013 ◽  
Vol 13 (23) ◽  
pp. 2955-2964 ◽  
Author(s):  
Tiziana Vaisitti ◽  
Valentina Audrito ◽  
Sara Serra ◽  
Cinzia Bologna ◽  
Francesca Arruga ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Lymphocytic Leukemia ◽  
Disease Modifier

scholarly journals Programmed cell death 1 as prognostic marker and therapeutic target in upper gastrointestinal cancers

2021 ◽  
Vol 220 ◽  
pp. 153390
Author(s):  
Negar Khoshghamat ◽  
Niloufar Jafari ◽  
Mehrdad Moetamani-Ahmadi ◽  
Ghazaleh Khalili-Tanha ◽  
Mohammad-Hossein Khajavi rad ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Gastrointestinal Cancers ◽  
Programmed Cell Death 1 ◽  
Upper Gastrointestinal

scholarly journals COUP-TFII, a prognostic marker and therapeutic target for prostate cancer

2013 ◽  
Vol 15 (3) ◽  
pp. 360-361 ◽  
Author(s):  
Jun Qin ◽  
Sophia Tsai ◽  
Ming-Jer Tsai
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target

scholarly journals FoxM1 is an independent poor prognostic marker and therapeutic target for advanced Middle Eastern breast cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (25) ◽  
pp. 17466-17482 ◽  
Author(s):  
Abdul Khalid Siraj ◽  
Poyil Pratheeshkumar ◽  
Sandeep Kumar Parvathareddy ◽  
Zeeshan Qadri ◽  
Saravanan Thangavel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Middle Eastern

scholarly journals Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer

Oncogene ◽  
2014 ◽  
Vol 34 (16) ◽  
pp. 2094-2102 ◽  
Author(s):  
U Orfanelli ◽  
E Jachetti ◽  
F Chiacchiera ◽  
M Grioni ◽  
P Brambilla ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Antisense Transcription

The 9p21 locus as a potential therapeutic target and prognostic marker in colorectal cancer

2018 ◽  
Vol 19 (5) ◽  
pp. 463-474 ◽  
Author(s):  
Afsane Bahrami ◽  
Seyed Mahdi Hassanian ◽  
Majid Khazaei ◽  
Masoumeh Gharib ◽  
Mahsa Rahmani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
9P21 Locus

scholarly journals KLF7: a new candidate biomarker and therapeutic target for high-grade serous ovarian cancer

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Marta De Donato ◽  
Gabriele Babini ◽  
Simona Mozzetti ◽  
Marianna Buttarelli ◽  
Alessandra Ciucci ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Prognostic Marker ◽  
Late Stage ◽  
Therapeutic Target ◽  
Family Members ◽  
High Grade ◽  
Serous Ovarian Cancer

Abstract Background In spite of great progress in the surgical and clinical management, until now no significant improvement in overall survival of High-Grade Serous Ovarian Cancer (HGSOC) patients has been achieved. Important aspects for disease control remain unresolved, including unclear pathogenesis, high heterogeneity and relapse resistance after chemotherapy. Therefore, further research on molecular mechanisms involved in cancer progression are needed to find new targets for disease management. The Krüppel-like factors (KLFs) are a family of transcriptional regulators controlling several basic cellular processes, including proliferation, differentiation and migration. They have been shown to play a role in various cancer-relevant processes, in a context-dependent way. Methods To investigate a possible role of KLF family members as prognostic biomarkers, we carried out a bioinformatic meta-analysis of ovarian transcriptome datasets in different cohorts of late-stage HGSOC patients. In vitro cellular models of HGSOC were used for functional studies exploring the role of KLF7 in disease development and progression. Finally, molecular modelling and virtual screening were performed to identify putative KLF7 inhibitors. Results Bioinformatic analysis highlighted KLF7 as the most significant prognostic gene, among the 17 family members. Univariate and multivariate analyses identified KLF7 as an unfavourable prognostic marker for overall survival in late-stage TCGA-OV and GSE26712 HGSOC cohorts. Functional in vitro studies demonstrated that KLF7 can play a role as oncogene, driving tumour growth and dissemination. Mechanistic targets of KLF7 included genes involved in epithelial to mesenchymal transition, and in maintaining pluripotency and self-renewal characteristics of cancer stem cells. Finally, in silico analysis provided reliable information for drug-target interaction prediction. Conclusions Results from the present study provide the first evidence for an oncogenic role of KLF7 in HGSOC, suggesting it as a promising prognostic marker and therapeutic target.

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