Recent Advances in Understanding the Cellular Functions of BRCA1

2009 ◽  
pp. 75-92
Author(s):  
Ellen Solomon ◽  
Joanna R. Morris
Keyword(s):  
Cellular Functions ◽  
Recent Advances

scholarly journals Recent advances in p97/VCP/Cdc48 cellular functions

2012 ◽  
Vol 1823 (1) ◽  
pp. 130-137 ◽  
Author(s):  
Kunitoshi Yamanaka ◽  
Yohei Sasagawa ◽  
Teru Ogura
Keyword(s):  
Cellular Functions ◽  
Recent Advances

scholarly journals Recent Advances in the Therapeutic Development of Receptor Tyrosine Kinases (RTK) against Different Types of Cancer

2021 ◽  
Author(s):  
Somi Patranabis
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Therapeutic Strategies ◽  
Cellular Functions ◽  
Recent Advances ◽  
Different Types ◽  
Therapeutic Development ◽  
Potential Applications ◽  
Specific Ligand ◽  
Novel Therapeutic

Receptor Tyrosine Kinases (RTKs) are an important class of receptors involved in regulating different cellular functions. The usual pathway of RTK activation involves specific ligand binding, dimerization and trans-autophosphorylation. Recently, RTK has been extensively studied as they have potential applications in targeted cancer therapy. RTK-based therapeutic strategies are promising because dysfunction of RTK is connected to a variety of diseases. More specifically, RTK has been widely associated with different types of cancer and related diseases. The chapter aims to cover recent advances and challenges in RTK related research, to get an overview of the problems and possibilities associated with targeted therapy. This will help in deciphering novel therapeutic applications in the future.

scholarly journals The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives

2020 ◽  
Vol 21 (6) ◽  
pp. 2174
Author(s):  
Martin Kadlec ◽  
José Luis Ros-Santaella ◽  
Eliana Pintus
Keyword(s):  
Assisted Reproductive Technologies ◽  
Male Gamete ◽  
Cell Types ◽  
Reproductive Technologies ◽  
Mechanisms Of Action ◽  
Sperm Function ◽  
Sperm Cells ◽  
Cellular Functions ◽  
Recent Advances ◽  
Potential Use

After being historically considered as noxious agents, nitric oxide (NO) and hydrogen sulfide (H2S) are now listed as gasotransmitters, gaseous molecules that play a key role in a variety of cellular functions. Both NO and H2S are endogenously produced, enzymatically or non-enzymatically, and interact with each other in a range of cells and tissues. In spite of the great advances achieved in recent decades in other biological systems, knowledge about H2S function and interactions with NO in sperm biology is in its infancy. Here, we aim to provide an update on the importance of these molecules in the physiology of the male gamete. Special emphasis is given to the most recent advances in the metabolism, mechanisms of action, and effects (both physiological and pathophysiological) of these gasotransmitters. This manuscript also illustrates the physiological implications of NO and H2S observed in other cell types, which might be important for sperm function. The relevance of these gasotransmitters to several signaling pathways within sperm cells highlights their potential use for the improvement and successful application of assisted reproductive technologies.

scholarly journals Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1592-1603 ◽  
Author(s):  
Zaki S. Seddigi ◽  
M. Shaheer Malik ◽  
A Prasanth Saraswati ◽  
Saleh A. Ahmed ◽  
Ahmed O. Babalghith ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Crucial Role ◽  
Cellular Functions ◽  
Recent Advances ◽  
Promising Target ◽  
Anticancer Drug Development

The dynamic and crucial role of tubulin in different cellular functions rendered it a promising target in anticancer drug development.

Diverse Cellular Roles of Autophagy

2019 ◽  
Vol 35 (1) ◽  
pp. 453-475 ◽  
Author(s):  
Hideaki Morishita ◽  
Noboru Mizushima
Keyword(s):  
Metabolic Adaptation ◽  
Cellular Functions ◽  
Cellular Homeostasis ◽  
Selective Autophagy ◽  
Intracellular Degradation ◽  
Recent Advances ◽  
Essential Contribution

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular functions of macroautophagy, including its essential contribution to metabolic adaptation and cellular homeostasis. We also discuss emerging findings on the mechanisms and functions of various types of selective autophagy.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

Surface Structure of Nucleated Animal Cells: Carbon Replicas

1967 ◽  
Vol 25 ◽  
pp. 120-121
Author(s):  
Robert M. Glaeser ◽  
Thea B. Scott
Keyword(s):  
Cell Surface ◽  
Surface Structure ◽  
Particle Diameter ◽  
Cellular Functions ◽  
Animal Cells ◽  
Replica Technique ◽  
Carbon Replica ◽  
Characteristic Particle ◽  
Cell Surface Structure ◽  
Carbon Replicas

The carbon-replica technique can be used to obtain information about cell-surface structure that cannot ordinarily be obtained by thin-section techniques. Mammalian erythrocytes have been studied by the replica technique and they appear to be characterized by a pebbly or “plaqued“ surface texture. The characteristic “particle” diameter is about 200 Å to 400 Å. We have now extended our observations on cell-surface structure to chicken and frog erythrocytes, which possess a broad range of cellular functions, and to normal rat lymphocytes and mouse ascites tumor cells, which are capable of cell division. In these experiments fresh cells were washed in Eagle's Minimum Essential Medium Salt Solution (for suspension cultures) and one volume of a 10% cell suspension was added to one volume of 2% OsO4 or 5% gluteraldehyde in 0.067 M phosphate buffer, pH 7.3. Carbon replicas were obtained by a technique similar to that employed by Glaeser et al. Figure 1 shows an electron micrograph of a carbon replica made from a chicken erythrocyte, and Figure 2 shows an enlarged portion of the same cell.

Multimode light microscopy and fluorescence-based reagents as tools for the study of chemical and molecular dynamics of living cells and tissues

1992 ◽  
Vol 50 (1) ◽  
pp. 418-419
Author(s):  
D. L. Taylor
Keyword(s):  
Living Cells ◽  
Cellular Level ◽  
Molecular Techniques ◽  
Cellular Functions ◽  
Macromolecular Assemblies ◽  
Cell Functions ◽  
Molecular Events ◽  
Yield Information ◽  
Full Knowledge ◽  
Structural Methods

Cells function through the complex temporal and spatial interplay of ions, metabolites, macromolecules and macromolecular assemblies. Biochemical approaches allow the investigator to define the components and the solution chemical reactions that might be involved in cellular functions. Static structural methods can yield information concerning the 2- and 3-D organization of known and unknown cellular constituents. Genetic and molecular techniques are powerful approaches that can alter specific functions through the manipulation of gene products and thus identify necessary components and sequences of molecular events. However, full knowledge of the mechanism of particular cell functions will require direct measurement of the interplay of cellular constituents. Therefore, there has been a need to develop methods that can yield chemical and molecular information in time and space in living cells, while allowing the integration of information from biochemical, molecular and genetic approaches at the cellular level.

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