Regulation of Keratinocyte Differentiation by Vitamin D and Its Relationship to Squamous Cell Carcinoma

2010 ◽  
pp. 283-303
Author(s):  
Arnaud Teichert ◽  
Daniel D. Bikle
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Keratinocyte Differentiation

scholarly journals Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways

2020 ◽  
Vol 40 (5) ◽  
pp. 2467-2474 ◽  
Author(s):  
ALLEN S.W. OAK ◽  
GEORGETA BOCHEVA ◽  
TAE-KANG KIM ◽  
ANNA A. BROŻYNA ◽  
ZORICA JANJETOVIC ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Serum levels of 25‐hydroxy‐vitamin D in patients with oral squamous cell carcinoma: Making a case for chemoprevention

2020 ◽  
Vol 6 (4) ◽  
pp. 428-432
Author(s):  
Samuel E. Udeabor ◽  
Abdullah M. Albejadi ◽  
Waleed A. K. Al‐Shehri ◽  
Chidozie I. Onwuka ◽  
Saeed Y. Al‐Fathani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Levels ◽  
25 Hydroxy Vitamin D

scholarly journals Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

2019 ◽  
pp. 278-282
Author(s):  
Mahboobeh-Sadat Hosseini ◽  
Fereshteh Salarvand ◽  
Amir Houshang Ehsani ◽  
Pedram Noormohammadpour ◽  
Shadi Azizzadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Outdoor Environment ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
History Of ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression

Head & Neck ◽  
2006 ◽  
Vol 28 (5) ◽  
pp. 432-440 ◽  
Author(s):  
Parish P. Sedghizadeh ◽  
Susan R. Mallery ◽  
Sarah J. Thompson ◽  
Laura Kresty ◽  
F. Michael Beck ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Serine Protease ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Keratinocyte Differentiation

Is Vitamin D level relevant in patients with mouth cancer - Squamous Cell Carcinoma?

2019 ◽  
Vol 57 (10) ◽  
pp. e23
Author(s):  
Akinsola Ogunbowale ◽  
Kamil Hassan ◽  
Rohith Gaikwad ◽  
Leo Stassen
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Common genetic variants related to vitamin D status are not associated with esophageal squamous cell carcinoma risk in China

2015 ◽  
Vol 39 (2) ◽  
pp. 157-159 ◽  
Author(s):  
Jian-Bing Wang ◽  
Sanford M. Dawsey ◽  
Jin-Hu Fan ◽  
Neal D. Freedman ◽  
Ze-Zhong Tang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Genetic Variants ◽  
Vitamin D Status ◽  
Common Genetic Variants ◽  
Carcinoma Risk

Vitamin D and glucocorticoids in a murine squamous cell carcinoma model system*

1997 ◽  
Vol 117 (2) ◽  
pp. P126-P127
Author(s):  
M MCELWAIN ◽  
W YU ◽  
C JOHNSON
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Model System
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