Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

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Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis

Dermatology ◽

10.1159/000517514 ◽

2021 ◽

pp. 1-8

Author(s):

Yusuf Hasamoh ◽

Kunlawat Thadanipon ◽

Premjit Juntongjin

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Inverse Association ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Newcastle Ottawa Scale ◽

25 Hydroxyvitamin D ◽

The Relationship ◽

Ottawa Scale

Background: Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking. Objective: To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity. Methods: This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale. Results: Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = –9.02 ng/mL, 95% CI = –13.22 to –4.81, p < 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68–5.23, I2 = 72%). Also, vitamin D levels were negatively correlated with acne severity. Conclusion: This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne.

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PS02.041: VITAMIN D SIGNALING PATHWAYS CONFER THE SUSCEPTIBILITY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.041 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 131-132

Author(s):

Aifang Ji ◽

Yang Zhou

Keyword(s):

Vitamin D ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathways ◽

Squamous Cell ◽

Chinese Population ◽

Common Variants ◽

Vitamin D Metabolism ◽

Vitamin D Levels ◽

Vitamin D Signaling

Abstract Background Experimental studies have determined the chemopreventive effects of vitamin D against theesophageal squamous cell carcinoma (ESCC); however, results from the epidemiological studies arenot yet well established. The current study aimed to evaluate the associations between plasmavitamin D levels and variants on vitamin D metabolic-related genes with the risks for ESCC. Methods A hospital-based case-control study was performed. 670 ESCC patients and 598 controls were recruited in a Northern Chinese population. The vitamin D levels in the plasma were determined with the ELISA detection kits provided by R&D Company and following the manufacturer's instructions. The coefficients of variation for the 25(OH)D levels between-assay and within-assay were less than 12.5%. Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and theplasma 25(OH)D level were determined. The genomic DNA was extracted from the blood lymphocyte cells with the QIAamp DNA Mini Kit (Qiagen, Germany). The SNPs were genotyped using the GenomeLab SNPstream 12-plex Genotyping System (Beckman Coulter, Inc., Fullerton, CA) following the manufacturer's instructions. The unconditional logistic regression method was applied to determine the associations between the variants and vitamin D level and ESCC. Results we evaluated 6 common variants on genes related to vitamin D metabolism including DHCR7 (rs3829251), DBP (rs12512631 and rs115563), CYP24A1 (rs2296241), CYP27B1 (rs4646536) and VDR (rs11568820) and their association with ESCC risk. For rs2296241, rs11568820 and rs4646536, interaction analysis shows that higher the plasma 25(OH)D levels are associated with a decreased ESCC risk.For rs3829251, rs3829251 and rs1155563, the plasma 25(OH)D levels did not vary across genotypes for any of the polymorphisms. The variants rs2296241 on CYP24A1 and rs11568820 on VDR are significantly associated with ESCC cancer. Conclusion Vitamin D signaling pathways may participate in the ESCC development. Further studies with larger sample size are warranted to confirm the results. Intervention studies are needed to determine whether vitamin D supplementation may reduce the ESCC risk in the Chinese population. Disclosure All authors have declared no conflicts of interest.

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Correlation between vitamin D levels and hard-to-heal wounds: a systematic review

Journal of Wound Care ◽

10.12968/jowc.2020.29.sup7.s24 ◽

2020 ◽

Vol 29 (Sup7) ◽

pp. S24-S30 ◽

Cited By ~ 1

Author(s):

Karen Smith ◽

Susan Hewlings

Keyword(s):

Vitamin D ◽

Financial Burden ◽

Vitamin D Supplementation ◽

Nutritional Deficiencies ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Venous Ulcers ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing. Method: PubMed and EBSCO databases were searched following PRISMA guidelines for primary research studies relating to pressure ulcers, diabetic ulcers or venous ulcers and vitamin D status. Results: A total of 10 studies, involving 2359 participants, met the inclusion criteria. There was a strong correlation between low levels of 25-hydroxyvitamin D and the presence of all three types of hard-to-heal wounds. Conclusion: Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is needed to understand the correlation between vitamin D and hard-to-heal wounds.

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Study on the relationship between serum 25-hydroxyvitamin D levels and vascular calcification in hemodialysis patients with consideration of seasonal variation in vitamin D levels

Atherosclerosis ◽

10.1016/j.atherosclerosis.2011.11.028 ◽

2012 ◽

Vol 220 (2) ◽

pp. 563-568 ◽

Cited By ~ 8

Author(s):

Jae Hyun Chang ◽

Han Ro ◽

Sejoong Kim ◽

Hyun Hee Lee ◽

Wookyung Chung ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Vascular Calcification ◽

Hemodialysis Patients ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

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Correlation between vitamin D levels and hard-to-heal wounds: a systematic review

Journal of Wound Care ◽

10.12968/jowc.2021.30.sup6.s4 ◽

2021 ◽

Vol 30 (Sup6) ◽

pp. S4-S10

Author(s):

Karen Smith ◽

Susan Hewlings

Keyword(s):

Vitamin D ◽

Financial Burden ◽

Vitamin D Supplementation ◽

Nutritional Deficiencies ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Venous Ulcers ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

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Relationship of vitamin D, BMI and BMD in age and gender linked population

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20181439 ◽

2018 ◽

Vol 4 (3) ◽

pp. 406

Author(s):

Ritwik Ganguli ◽

Priyanka Pahari

Keyword(s):

Vitamin D ◽

Vitamin D Insufficiency ◽

Healthy Individuals ◽

Mineral Density ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

And Gender ◽

Relationship Of ◽

The Relationship

Background: Vitamin D insufficiency prevalence has been related to low bone mineral density (BMD). However, controversial results have been reported for the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and BMD. This study was done to investigate whether serum 25(OH)D levels were associated with BMD in different age group and sex link population.Methods: This study involved, aged 40-70 yr, who is consecutively selected from KPCMCH, BMD camp. BMD was measured at the lumbar spine and femoral neck. The correlation between serum 25(OH)D levels and BMD was investigated.Results: Vitamin D levels for healthy and patients individuals at hospital. The age of 40 healthy subjects ranged from 40 to 70 years with the average of 55.30±10.30 years and body mass index (BMI) ranged from 18 to 37 kg/m2, with the of average of 28.90±5.20 kg/m2. Comparison between healthy and patients based on BMI and vitamin D level for the overweight BMI healthy individuals was 29.78±9.40 ng/ml, and that of hyperlipidemic patients was 24.47±8.78 ng/ml.Conclusions: In this study, there is significant different between healthy and patients group in vitamin D3level.BMD significantly decreased in patients group more elderly.

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Evaluation of vitamin D levels and body mass indexes of university employees

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v19i2.45000 ◽

2020 ◽

Vol 19 (2) ◽

pp. 229-236

Author(s):

Murat Emrah MAVİŞ ◽

Çiğdem YILDIRIMMAVİŞ ◽

İrem ÖZAY ARANCIOĞLU ◽

Hatice Kübra YILMAZ ◽

Berrak ERGÜDEN ◽

...

Keyword(s):

Vitamin D ◽

Body Mass ◽

Anthropometric Measurement ◽

University Employees ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

25 Hydroxyvitamin D ◽

Body Mass Indexes ◽

The Relationship

Objective: Vitamin D is known to have important effects on human health. The existence of a relationship between obesity and vitamin D levels, which have been shown to cause a number of health problems with various studies, is certain. In this study, the relationship between vitamin D levels and body mass indexes(BMI) of individuals was evaluated. The study is unique for being the only research on literature that carried out with university employees. Materials and methods: Blood samples, anthropometric measurement (BMI) was obtained from 87 volunteer working at Haliç University. The questionnaire form covering the basic questions applied by means of face-to-face method. Quantification of the analytes for 25-hydroxyvitamin-D was carried out using LC-MS/MS. The relationship between 25-hydroxyvitamin-D values and BMI was evaluated with Tukey HSD multiple comparison test. 95% confidence and 80% power sampling were applied to the predictions of a minimum0.50 connection coefficient between 2 quantitative variables.The necessity of 30 cases was determined by using the N = [(Zα+Zβ)/C]2 + 3formula.Considering the losses, the work will be carried out over 80 people. Results and Discussion: There’s significant difference between 25-hydroxyvitamin-D2 and 25-hydroxyvitamin-D3 and the BMI levels of the subjects(p:0.028<0.05-p:0.000<0.05). The average 25-hydroxyvitamin-D3 and 25-hydroxyvitamin-D2 levels of overweight participants were significantly higher than the mean levels of underweight participants’. No significant relationship was found between 25-hydroxyvitamin-D3 and 25-hydroxyvitamin-D2 levels and the time spent outdoors during summer and winter. Conclusion: To prevent vitamin D deficiency and insufficiency is to obtain some sensible sun exposure, ingest foods that contain vitamin D, and take supplement. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.229-236

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Prevalence of Vitamin D Deficiency among Patients Attending a General Otolaryngology Clinic in South Auckland

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940911800502 ◽

2009 ◽

Vol 118 (5) ◽

pp. 326-328 ◽

Cited By ~ 5

Author(s):

Jim Bartley ◽

David Reid ◽

Randall P. Morton

Keyword(s):

Vitamin D ◽

Statistical Analysis ◽

Vitamin D Deficiency ◽

Prospective Observational Study ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

Relationship Of ◽

The Relationship

Objectives: We performed a prospective observational study to estimate the prevalence of vitamin D deficiency in patients attending a general otolaryngology clinic in South Auckland, New Zealand. Methods: From July 21, 2008, to August 7, 2008, all new patients presenting to otolaryngology clinics at which one of the authors (D.R.) was present had their vitamin D status assessed by measurement of their plasma 25-hydroxyvitamin D [25(OH)D] level. Results: Of 48 patients, 2% had 25(OH)D levels of 17.5 nmol/L or less (a level associated with osteomalacia), 58% had 25(OH)D levels of 50 nmol/L or less (a level associated with vitamin D deficiency), and 100% had 25(OH)D levels of 80 nmol/L or less. Conclusions: Most of the patients attending a general otolaryngology clinic in South Auckland are vitamin D–deficient. It is unclear whether low vitamin D levels are associated more directly with otolaryngological disorders or skin type, because the small size of this study and the broad range of conditions seen precluded a meaningful statistical analysis. Further research into the relationship of vitamin D to specific otolaryngological presentations is required.

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Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature

BMJ Case Reports ◽

10.1136/bcr-2020-236477 ◽

2021 ◽

Vol 14 (1) ◽

pp. e236477

Author(s):

Subhash Soni ◽

Poonam Elhence ◽

Vaibhav Kumar Varshney ◽

Sunita Suman

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Survival Rates ◽

Ampulla Of Vater ◽

Metallic Stent ◽

Biological Behaviour ◽

Curative Intent ◽

Term Survival ◽

History Of

Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.

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Leiomyosarcoma of the Tracheostomy Site in a Patient with History of Laryngeal Squamous Cell Carcinoma

Case Reports in Oncology ◽

10.1159/000516797 ◽

2021 ◽

pp. 912-917

Author(s):

Zainub Ajmal ◽

Abdul Moiz Khan ◽

Lezah McCarthy ◽

Allison Lupinetti ◽

Syed Mehdi

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

English Literature ◽

Neck Region ◽

Multiple Risk Factors ◽

History Of ◽

Rare Malignancy

Leiomyosarcoma (LMS) of the trachea is an extremely rare malignancy with only a few reported cases in English literature. As such the diagnosis can be frequently missed or delayed. We present a case of a 69-year-old male who underwent tracheostomy for airway obstruction secondary to glottic squamous cell carcinoma and treated definitely with radiation therapy. Subsequently, the patient developed LMS of the tracheostomy site. The case further details multiple risk factors that could contribute to development of LMS including radiation exposure, prior malignancy, and chronic inflammation. These risk factors have been well established for LMS in other sites but less so in the head and neck region, which is the subject of our discussion. We also review the current guidelines for head and neck as well as limb sarcomas and discussed role of surgery or radiation and their accompanying challenges in management of this rare malignancy.

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