Anti-Excitotoxic Therapies in Neurologic Diseases: Current Evidences and New Perspectives

2004 ◽  
pp. 339-354
Author(s):  
Laura Brighina ◽  
Angelo Aliprandi ◽  
Simone Beretta ◽  
Carlo Ferrarese
Keyword(s):  
Neurologic Diseases

Neuopeptides as CSF markers in neurologic diseases

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S95-S96
Author(s):  
A. WEINDL ◽  
J. UNGER ◽  
G. OCHS ◽  
M. SCHWARTZBERG ◽  
W. LANGE ◽  
...  
Keyword(s):  
Neurologic Diseases

Bullous Pemphigoid and Neurologic Diseases: Toward a Specific Serologic Profile?

2018 ◽  
Vol 18 (6) ◽  
pp. 662-664 ◽  
Author(s):  
Miriana Rosaria Petrera ◽  
Marilina Tampoia ◽  
Stefania Guida ◽  
Letizia Abbracciavento ◽  
Ruggiero Fumarulo ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Neurologic Diseases

Meningoencephalomyelitis in domestic cats: 3 cases of Pasteurella multocida infection and literature review

2021 ◽  
pp. 104063872110344
Author(s):  
Bianca S. de Cecco ◽  
Mariano Carossino ◽  
Fabio Del Piero ◽  
Nobuko Wakamatsu ◽  
Maria S. Mitchell ◽  
...  
Keyword(s):  
Pasteurella Multocida ◽  
Case Series ◽  
Infectious Agents ◽  
Domestic Cats ◽  
Neurologic Diseases ◽  
Gram Negative ◽  
The Central Nervous System ◽  
Upper Respiratory ◽  
Portal Of Entry ◽  
Histologic Changes

Neurologic diseases are common in domestic cats, and infectious agents are suspected to be the primary cause in 30–45% of cases. Among infectious etiologies, those of bacterial origin are only sporadically characterized in the literature, with few of these reports correlating gross and histologic findings with confirmatory bacteriologic identification. Here, we describe bacterial meningitis and meningoencephalomyelitis associated with Pasteurella multocida in 3 domestic cats. Purulent exudate expanding the cerebral meninges was grossly evident in 2 of the cases. In all 3 cases, histologic changes included multifocal suppurative-to-necrosuppurative meningitis and/or meningoencephalomyelitis of variable severity. Intralesional colonies of gram-negative, short rod-shaped to coccobacillary bacteria were evident histologically in only 1 case. P. multocida was confirmed by routine bacteriologic culture in all cases. Based on our cases, we hypothesize that the upper respiratory system serves as the main portal of entry for P. multocida, leading to invasion of the central nervous system and possible systemic hematogenous dissemination. A case series of meningoencephalomyelitis associated with P. multocida infection in cats has not been reported previously, to our knowledge. We also review briefly other causes of meningoencephalomyelitis in cats.

 1-Antitrypsin in Cerebrospinal Fluid of Patients With Neurologic Diseases

1985 ◽  
Vol 42 (8) ◽  
pp. 775-777 ◽  
Author(s):  
G. S. Pearl ◽  
R. E. Mullins
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Diseases

Pediatric Neurology

PEDIATRICS ◽  
1959 ◽  
Vol 24 (3) ◽  
pp. 361-361
Author(s):  
JOHN STOBO PRICHARD
Keyword(s):  
Cerebral Palsy ◽  
Neurologic Diseases ◽  
Pediatric Neurology ◽  
Comprehensive Account ◽  
Cerebral Infections ◽  
Clinical Conditions

It is generally considered that a good textbook should be either very complete or relatively short and readable, describing the most important clinical conditions in some detail and briefly mentioning the rest. This book is certainly not a comprehensive account of the neurologic diseases of childhood. Neither is it very short. But it does contain some useful material. In particular there is a practical account of the problems of cerebral palsy, and the cerebral infections are covered in some detail. Some people will disagree with a number of statements in the book.

Abstract WP239: Real Time Prospective Measurement of aPTT Predicts Paradoxical Embolism in Cryptogenic Stroke

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Bo Song ◽  
Wenjun Deng ◽  
Lindsay Fisher ◽  
I-ying Chou ◽  
Max Oyer ◽  
...  
Keyword(s):  
Real Time ◽  
Protein C ◽  
Cryptogenic Stroke ◽  
Protein S ◽  
Paradoxical Embolism ◽  
Proof Of Concept ◽  
Stroke Patients ◽  
Neurologic Diseases ◽  
Coagulation Testing ◽  
Coagulation Status

Patent foramen ovale (PFO) is an important underlying source of cryptogenic stroke (CS) associated with hematologic procoagulability. However, the association of genetically identified hyperocagulability and paradoxical embolism has been difficult to establish due to retrospective analysis and the limited numbers of of known genetically identified hypercoagulable conditions. In this study, we explored the utility of conventional coagulation status in PFO related stroke, as the patients may harbor genetically unidentified hyperocoagulable conditions. Method: Eligible pts were prospectively recruited in accordance with IRB, and underwent conventional coagulation testing (PT/PTT) testing within 12 hours of stroke. All patients underwent full cryptogenic workup such as MRI/MRA, mobile cardiac outpatient telemetry (>30 days), cardiac echo, and hypercoagulable testing. Results: We screened 4,831 pts admitted with acute neurologic diseases, and recruited 358 eligible acute ischemic stroke pts. 54 (15.1%) pts had CS and 32 pts had PFO related stroke. While there is no difference between PFO-related CS and PFO-unrelated CS on full hypercaogulable screen (protein S, protein C, FVL, PTGM, ATIII, APLAb, LA, hcy), aPTT was statistically significantly shortened in PFO-related stroke patients (PFO CS vs. non-PFO CS: aPTT 27.2±4.1s vs. 29.9±2.3s). ROC curve indicates early shortened aPTT can predict PFO related stroke (sensitivity 70%, specificity 81.5%, p=0.017) (see Figure). Conclusion: We found real time aPTT to be significantly shortened in patients eventually diagnosed with paradoxical embolism related to PFO. While studies in larger pt cohorts accounting for other potential confounders are underway, this proof-of-concept study demonstrates the importance and utility of early conventional coagulation testing in identifying paradoxical embolism. Pts with shortened aPTT may need additional workup for other underlying hypercoagulable conditions.

Neurogastroenterology

2015 ◽  
Author(s):  
Ronald F. Pfeiffer
Keyword(s):  
Wilson Disease ◽  
The Other ◽  
Neurologic Disease ◽  
Rare Disorders ◽  
Neurologic Diseases ◽  
Neurologic Dysfunction ◽  
Acquired Hepatocerebral Degeneration ◽  
Whipple Disease ◽  
Hepatocerebral Degeneration ◽  
Inflammatory Bowel

Contrary to what one may assume, neurology and gastroenterology are similar to each other in many ways. A process found in one system can also affect the other, whether it be gastrointestinal (GI) dysfunction present in neurologic diseases or neurologic dysfunction present in GI diseases. Several disorders from both fields of medicines are highlighted in this review, ranging from stroke, Parkinson disease, and multiple sclerosis (MS) as examples of GI dysfunction in neurologic disease, to celiac disease and inflammatory bowel disease as examples of neurologic dysfunction in GI disease. Rare disorders such as Whipple disease (WhD), chronic acquired hepatocerebral degeneration (CAHD), and Wilson disease (WD) should also be considered for their neurologic dysfunctions as manifested extraintestinally. Tables give an overview of clinical features of the various disorders presented in this review.   This module contains ­4 highly rendered figures, 9 tables, 349 references, and 5 MCQs. 

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