Along with the in-depth development of higher education and teaching reform in China, multimedia technology has been widely applied in classroom teaching, which not only provides a new field for optimization of teaching process and renovation of teaching methods, but also plays a significant role on the enhancement of instructional quality and the promotion of teaching reform. However, some negative issues still affect teaching effect in present higher education institutions, because of being lack of an efficient and scientific instructional evaluation system. In this paper, after the analysis of the advantages of applying the multimedia for the sake of teaching method reformation and teaching effect improvement, the negative effects exist in the process of multimedia teaching application are discussed. Moreover, the measurements of employing multimedia teaching to promote teaching effect is proposed, and the procedures of building a scientific evaluation index system is summarized, which includes creating standards of multimedia teaching effectiveness, the management systems, and the composition of courseware, etc.