Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models

2014 ◽  
pp. 111-129
Author(s):  
Janet van Eersel ◽  
Fabien Delerue ◽  
Lars M. Ittner ◽  
Yazi D. Ke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Frontotemporal Lobar Degeneration

scholarly journals Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s disease and frontotemporal lobar degeneration

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Anna L Cranston ◽  
Adrianna Wysocka ◽  
Marta Steczkowska ◽  
Maciej Zadrożny ◽  
Ewelina Palasz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Choline Acetyltransferase ◽  
Basal Forebrain ◽  
Calcium Binding ◽  
Frontotemporal Lobar Degeneration ◽  
Ionized Calcium ◽  
Adaptor Molecule ◽  
Inflammatory Phenotypes

Abstract An early and sizeable loss of basal forebrain cholinergic neurons is a well-characterized feature associated with measurable deficits in spatial learning and cognitive impairment in patients with Alzheimer’s disease. In addition, pro-inflammatory glial cells such as astrocytes and microglia may play a key role in the neurodegenerative cascade of Alzheimer’s disease and tauopathies. We recently presented two mouse models: Line 1, expressing the truncated tau fragment identified as the core of the Alzheimer’s paired helical filament, and Line 66, expressing full-length human tau carrying a double mutation (P301S and G335D). Line 1 mice have a pathology that is akin to Alzheimer’s, whilst Line 66 resembles frontotemporal lobar degeneration. However, their cholinergic and inflammatory phenotypes remain elusive. We performed histological evaluation of choline acetyltransferase, acetylcholinesterase, p75 neurotrophin receptor, microglial ionized calcium binding adaptor molecule 1 and astrocytic glial fibrillary acidic protein in the basal forebrain, hippocampus and cortex of these models. A significant lowering of choline acetyltransferase-positive neurons and p75-positive neurons in the basal forebrain of Line 1 at 3, 6 and 9 months was observed in two independent studies, alongside a significant decrease in acetylcholinesterase staining in the cortex and hippocampus. The reductions in choline acetyltransferase positivity varied between 30% and 50% at an age when Line 1 mice show spatial learning impairments. Furthermore, an increase in microglial ionized calcium binding adaptor molecule 1 staining was observed in the basal forebrain, hippocampus and entorhinal cortex of Line 1 at 6 months. Line 66 mice displayed an intact cholinergic basal forebrain, and no difference in p75-positive neurons at 3 or 9 months. In addition, Line 66 exhibited significant microglial ionized calcium binding adaptor molecule 1 increase in the basal forebrain and hippocampus, suggesting a prominent neuroinflammatory profile. Increased concentrations of microglial interleukin-1β and astrocytic complement 3 were also seen in the hippocampus of both Line 1 and Line 66. The cholinergic deficit in Line 1 mice confirms the Alzheimer’s disease-like phenotype in Line 1 mice, whilst Line 66 revealed no measurable change in total cholinergic expression, a phenotypic trait of frontotemporal lobar degeneration. These two transgenic lines are therefore suitable for discriminating mechanistic underpinnings between the Alzheimer’s and frontotemporal lobar degeneration-like phenotypes of these mice.

Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models

2018 ◽  
pp. 187-219 ◽  
Author(s):  
Lars M. Ittner ◽  
Wei S. Lee ◽  
Kristie Stefanoska ◽  
Prita R. Asih ◽  
Yazi D. Ke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Frontotemporal Lobar Degeneration

scholarly journals Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models

2021 ◽  
Author(s):  
Satoshi Muraoka ◽  
Mark P. Jedrychowski ◽  
Naotoshi Iwahara ◽  
Mohammad Abdullah ◽  
Kristen D. Onos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Extracellular Vesicles

Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease

2013 ◽  
Vol 106 ◽  
pp. 57-67 ◽  
Author(s):  
Chun-Ming Wang ◽  
Ming-Yan Liu ◽  
Fang Wang ◽  
Min-Jie Wei ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amnesic Effect

CCL8/MCP-2 association analysis in patients with Alzheimer’s disease and frontotemporal lobar degeneration

2009 ◽  
Vol 256 (8) ◽  
pp. 1379-1381 ◽  
Author(s):  
Chiara Villa ◽  
Eliana Venturelli ◽  
Chiara Fenoglio ◽  
Francesca Clerici ◽  
Alessandra Marcone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Analysis ◽  
Frontotemporal Lobar Degeneration
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