CCL8/MCP-2 association analysis in patients with Alzheimer’s disease and frontotemporal lobar degeneration

2009 ◽  
Vol 256 (8) ◽  
pp. 1379-1381 ◽  
Author(s):  
Chiara Villa ◽  
Eliana Venturelli ◽  
Chiara Fenoglio ◽  
Francesca Clerici ◽  
Alessandra Marcone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Analysis ◽  
Frontotemporal Lobar Degeneration

scholarly journals The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Elisa Ridolfi ◽  
Cinzia Barone ◽  
Elio Scarpini ◽  
Daniela Galimberti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Lobar Degeneration ◽  
Environmental Changes ◽  
Current Evidence ◽  
Neuronal Function ◽  
Immune Effector ◽  
Effector Cells ◽  
The Central Nervous System

In the last few years, genetic and biomolecular mechanisms at the basis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) have been unraveled. A key role is played by microglia, which represent the immune effector cells in the central nervous system (CNS). They are extremely sensitive to the environmental changes in the brain and are activated in response to several pathologic events within the CNS, including altered neuronal function, infection, injury, and inflammation. While short-term microglial activity has generally a neuroprotective role, chronic activation has been implicated in the pathogenesis of neurodegenerative disorders, including AD and FTLD. In this framework, the purpose of this review is to give an overview of clinical features, genetics, and novel discoveries on biomolecular pathogenic mechanisms at the basis of these two neurodegenerative diseases and to outline current evidence regarding the role played by activated microglia in their pathogenesis.

P4-074: ITALIAN NETWORK FOR AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN)

2014 ◽  
Vol 10 ◽  
pp. P810-P810
Author(s):  
Martina Bocchetta ◽  
Michela Pievani ◽  
Claudio Babiloni ◽  
Amalia C. Bruni ◽  
Elio Scarpini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Lobar Degeneration ◽  
Autosomal Dominant ◽  
Autosomal Dominant Alzheimer’S Disease

scholarly journals Risk of caregiver burden in patients with three types of dementia

2019 ◽  
Vol 31 (1) ◽  
pp. 153-153
Author(s):  
Tomoyuki Kawada
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Caregiver Burden ◽  
Frontotemporal Lobar Degeneration ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Behavioral Disturbances

Liu et al. (2017) investigated caregiver burden of patients with frontotemporal lobar degeneration (FTD) and dementia with Lewy bodies (DLB), which was compared with caregivers of patients with Alzheimer's disease. The authors concluded that the frequency and severity of behavioral disturbances in caregiver of patients with FTD and DLB were higher than those with caregivers of patients with Alzheimer's disease. I have some concerns about their study.

scholarly journals Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

2020 ◽  
Vol 26 (3) ◽  
pp. 387-397 ◽  
Author(s):  
Elisabeth H. Thijssen ◽  
◽  
Renaud La Joie ◽  
Amy Wolf ◽  
Amelia Strom ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Lobar Degeneration ◽  
Diagnostic Value

P3-219: Progranulin gene mutation scanning in Alzheimer's disease and frontotemporal lobar degeneration: Functional and phenotypic correlations

2008 ◽  
Vol 4 ◽  
pp. T585-T585 ◽  
Author(s):  
Daniela Galimberti ◽  
Chiara Fenoglio ◽  
Francesca Cortini ◽  
Eliana Venturelli ◽  
Ilaria Guidi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Mutation ◽  
Frontotemporal Lobar Degeneration ◽  
Mutation Scanning ◽  
Phenotypic Correlations
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