Regulation of Candida albicans Populations in the Gastrointestinal Tract: Mechanisms and Significance in GI and Systemic Candidiasis

1989 ◽  
pp. 315-402 ◽  
Author(s):  
Michael J. Kennedy
Keyword(s):  
Candida Albicans ◽  
Gastrointestinal Tract ◽  
Systemic Candidiasis

scholarly journals Spontaneous (Primary) Candida peritonitis

1995 ◽  
Vol 9 (3) ◽  
pp. 144-146
Author(s):  
Joe Sukhabote ◽  
Hugh J Freeman
Keyword(s):  
Candida Albicans ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Amphotericin B ◽  
Ascitic Fluid ◽  
Systemic Candidiasis ◽  
Local Infection ◽  
Immunological Disorder ◽  
Candida Peritonitis

A 49-year-old female presented with abdominal pain and ascites. Subsequent investigations revealedCandida albicansin the ascitic fluid without evidence of systemic candidiasis or a source of local infection in another site. Additional studies revealed no evident underlying immunological disorder and the gastrointestinal tract was intact. Therapy with amphotericin B led to resolution of abdominal pain and ascites with no recurrence.

scholarly journals Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model

2011 ◽  
Vol 315 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Alireza Khodavandi ◽  
Fahimeh Alizadeh ◽  
Nabil S. Harmal ◽  
Shiran M. Sidik ◽  
Fauziah Othman ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Mouse Model ◽  
Systemic Candidiasis

scholarly journals The HOG Pathway Is Critical for the Colonization of the Mouse Gastrointestinal Tract by Candida albicans

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87128 ◽  
Author(s):  
Daniel Prieto ◽  
Elvira Román ◽  
Inês Correia ◽  
Jesus Pla
Keyword(s):  
Candida Albicans ◽  
Gastrointestinal Tract ◽  
Hog Pathway

scholarly journals Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a NovelIn VitroMucosal Model

2011 ◽  
Vol 80 (2) ◽  
pp. 620-632 ◽  
Author(s):  
Patricia I. Diaz ◽  
Zhihong Xie ◽  
Takanori Sobue ◽  
Angela Thompson ◽  
Basak Biyikoglu ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Gastrointestinal Tract ◽  
Oral Mucosa ◽  
Biofilm Formation ◽  
Salivary Flow ◽  
Flow Cell ◽  
Synergistic Interaction ◽  
Esophageal Mucosa ◽  
Oral Streptococci ◽  
Content Type

ABSTRACTCandida albicansis a commensal colonizer of the gastrointestinal tract of humans, where it coexists with highly diverse bacterial communities. It is not clear whether this interaction limits or promotes the potential ofC. albicansto become an opportunistic pathogen. Here we investigate the interaction betweenC. albicansand three species of streptococci from the viridans group, which are ubiquitous and abundant oral commensal bacteria. The ability ofC. albicansto form biofilms withStreptococcus oralis,Streptococcus sanguinis, orStreptococcus gordoniiwas investigated using flow cell devices that allow abiotic biofilm formation under salivary flow. In addition, we designed a novel flow cell system that allows mucosal biofilm formation under conditions that mimic the environment in the oral and esophageal mucosae. It was observed thatC. albicansand streptococci formed a synergistic partnership whereC. albicanspromoted the ability of streptococci to form biofilms on abiotic surfaces or on the surface of an oral mucosa analogue. The increased ability of streptococci to form biofilms in the presence ofC. albicanscould not be explained by a growth-stimulatory effect since the streptococci were unaffected in their growth in planktonic coculture withC. albicans. Conversely, the presence of streptococci increased the ability ofC. albicansto invade organotypic models of the oral and esophageal mucosae under conditions of salivary flow. Moreover, characterization of mucosal invasion by the biofilm microorganisms suggested that the esophageal mucosa is more permissive to invasion than the oral mucosa. In summary,C. albicansand commensal oral streptococci display a synergistic interaction with implications for the pathogenic potential ofC. albicansin the upper gastrointestinal tract.

Impact of serial systemic infection on Candida albicans virulence factors

2020 ◽  
Vol 15 (13) ◽  
pp. 1249-1263
Author(s):  
Glaucia S Arita ◽  
Daniella R Faria ◽  
Karina M Sakita ◽  
Franciele AV Rodrigues-Vendramini ◽  
Isis RG Capoci ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Virulence Factors ◽  
Murine Model ◽  
Systemic Infection ◽  
Systemic Candidiasis ◽  
Fungal Burden ◽  
Histopathological Findings ◽  
Phenotypic Profile ◽  
Proteomic Data ◽  
Repeated Contact

Aim: To evaluate changes in virulence and pathogenicity approaches from Candida albicans after successive passages in a murine model of systemic candidiasis. Materials & methods: Phenotypic assays were performed using colonies recovered from animals infected serially, totalizing five passages. Results: A progressive infection was observed along the passages, with increased fungal burden and the presence of greater inflammatory areas in the histopathological findings. Recovered strains exhibited increased filamentation and biofilm abilities, along with modulation of phospholipase and proteinase activities. Conclusion: Repeated contact between yeast and host increased the expression of virulence factors. Furthermore, a correspondence between phenotypic profile and proteomic data obtained previously was observed.

scholarly journals CX3CR1 Is Dispensable for Control of Mucosal Candida albicans Infections in Mice and Humans

2014 ◽  
Vol 83 (3) ◽  
pp. 958-965 ◽  
Author(s):  
Timothy J. Break ◽  
Martin Jaeger ◽  
Norma V. Solis ◽  
Scott G. Filler ◽  
Carlos A. Rodriguez ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Human Population ◽  
Systemic Candidiasis ◽  
Gi Tract ◽  
Content Type ◽  
Commensal Microbiota ◽  
Interleukin 17A ◽  
Mucosal Surfaces ◽  
Bacterial Microbiota ◽  
Mucosal Candidiasis

Candida albicansis part of the normal commensal microbiota of mucosal surfaces in a large percentage of the human population. However, perturbations of the host's immune response or bacterial microbiota have been shown to predispose individuals to the development of opportunisticCandidainfections. It was recently discovered that a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis. However, whether CX3CR1 confers protection against mucosalC. albicansinfection has not been investigated. Using two different mouse models, we found that Cx3cr1 is dispensable for the induction of interleukin 17A (IL-17A), IL-22, and IL-23 in the tongue after infection, as well as for the clearance of mucosal candidiasis from the tongue or lower gastrointestinal (GI) tract colonization. Furthermore, the dysfunctional human CX3CR1 alleleCX3CR1-M280was not associated with development of recurrent vulvovaginal candidiasis (RVVC) in women. Taken together, these data indicate that CX3CR1 is not essential for protection of the host against mucosal candidiasis, underscoring the dependence on different mammalian immune factors for control of mucosal versus systemicCandidainfections.

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