Effect of Ribosome-Inactivating Proteins on Ribosomes from Leishmania and Their Possible Uses in Chemotherapy

Leishmaniasis ◽  
1989 ◽  
pp. 773-779
Author(s):  
Pietro Cenini ◽  
Fiorenzo Stirpe
Keyword(s):  
Ribosome Inactivating Proteins

scholarly journals Effect of RIP Overexpression on Abiotic Stress Tolerance and Development of Rice

2021 ◽  
Vol 22 (3) ◽  
pp. 1434
Author(s):  
Pieter Wytynck ◽  
Jeroen Lambin ◽  
Simin Chen ◽  
Sinem Demirel Asci ◽  
Isabel Verbeke ◽  
...  
Keyword(s):  
Methyl Jasmonate ◽  
Stress Responses ◽  
Abiotic Stress Tolerance ◽  
Protein Translation ◽  
Ribosome Inactivating Proteins ◽  
Close Proximity ◽  
Inhibit Protein Translation ◽  
Plant Ribosomes ◽  
A Cell ◽  
Type 3

Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can inhibit protein translation by depurinating rRNA. Most plant RIPs are synthesized with a leader sequence that sequesters the proteins to a cell compartment away from the host ribosomes. However, several rice RIPs lack these signal peptides suggesting they reside in the cytosol in close proximity to the plant ribosomes. This paper aims to elucidate the physiological function of two nucleocytoplasmic RIPs from rice, in particular, the type 1 RIP referred to as OsRIP1 and a presumed type 3 RIP called nuRIP. Transgenic rice lines overexpressing these RIPs were constructed and studied for developmental effects resulting from this overexpression under greenhouse conditions. In addition, the performance of transgenic seedlings in response to drought, salt, abscisic acid and methyl jasmonate treatment was investigated. Results suggest that both RIPs can affect methyl jasmonate mediated stress responses.

scholarly journals Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-Thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin

1988 ◽  
Vol 58 (5) ◽  
pp. 558-561 ◽  
Author(s):  
F Stirpe ◽  
EJ Wawrzynczak ◽  
ANF Brown ◽  
RE Knyba ◽  
GJ Watson ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Ribosome Inactivating Proteins

Type 1 ribosome-inactivating proteins from Phytolacca dioica L. leaves: differential seasonal and age expression, and cellular localization

Planta ◽  
2008 ◽  
Vol 228 (6) ◽  
pp. 963-975 ◽  
Author(s):  
Augusto Parente ◽  
Barbara Conforto ◽  
Antimo Di Maro ◽  
Angela Chambery ◽  
Paolo De Luca ◽  
...  
Keyword(s):  
Cellular Localization ◽  
Ribosome Inactivating Proteins
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