Mutations of Cellular Oncogenes as a Basis for Neoplastic Change

1984 ◽  
pp. 61-77 ◽  
Author(s):  
Harold E. Varmus
Keyword(s):  
Neoplastic Change ◽  
Cellular Oncogenes

scholarly journals A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1039
Author(s):  
Daisuke Takeda ◽  
Manabu Shigeoka ◽  
Tenyu Sugano ◽  
Nanae Yatagai ◽  
Takumi Hasegawa ◽  
...  
Keyword(s):  
Histological Finding ◽  
Atypical Epithelium ◽  
Diagnostic Dilemma ◽  
Barr Virus ◽  
Japanese Female ◽  
Old Japanese ◽  
Neoplastic Change ◽  
Diagnostic Difficulties ◽  
Epstein Barr ◽  
Characteristic Features

Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein–Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.

scholarly journals Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

2018 ◽  
Vol 10 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Ethan Frank ◽  
David Macias ◽  
Brian Hondorp ◽  
Justin Kerstetter ◽  
Jared C. Inman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Low Cost ◽  
Neck Mass ◽  
Inclusion Cyst ◽  
Neoplastic Change ◽  
Epidermal Inclusion Cyst ◽  
Hematoxylin And Eosin ◽  
Well Differentiated

Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining. Given the potential for variable presentation and low cost of hematoxylin and eosin analysis, we recommend a low threshold for a comprehensive pathological search for malignancy in excised cysts when appropriate.

EFFECT OF CIGARETTE SMOKING ON CERVICAL EPITHELIAL IMMUNITY: A MECHANISM FOR NEOPLASTIC CHANGE?

The Lancet ◽  
1988 ◽  
Vol 332 (8612) ◽  
pp. 652-654 ◽  
Author(s):  
S.E. Barton ◽  
D. Jenkins ◽  
J. Cuzick ◽  
P.H. Maddox ◽  
R. Edwards ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Neoplastic Change ◽  
Epithelial Immunity

Viral and cellular oncogenes promote immune evasion

Oncogene ◽  
2022 ◽  
Author(s):  
Jessica J. Roetman ◽  
Minna K. I. Apostolova ◽  
Mary Philip
Keyword(s):  
Immune Evasion ◽  
Cellular Oncogenes

Cellular oncogenes (c-erb-A and c-erb-B) located on different chicken chromosomes can be transduced into the same retroviral genome

1984 ◽  
Vol 4 (8) ◽  
pp. 1627-1630
Author(s):  
G Symonds ◽  
E Stubblefield ◽  
M Guyaux ◽  
J M Bishop
Keyword(s):  
Chicken Genome ◽  
Large Chromosome ◽  
Cellular Genes ◽  
Intermediate Size ◽  
Avian Erythroblastosis Virus ◽  
Cellular Oncogenes

Avian erythroblastosis virus has transduced two cellular genes, c-erb-A and c-erb-B. Using fractionated chicken chromosomes, we found that the two genes are located on different chromosomes in the chicken genome: c-erb-A is on a microchromosome, and c-erb-B is on a large chromosome. The locations of two other cellular oncogenes (c-fps and c-myb) were also determined: c-fps is on a microchromosome, and c-myb is on chromosome of an intermediate size. Our results suggest that avian erythroblastosis virus had transduced the two cellular genes independently, conforming to previous indications that cellular oncogenes are dispersed among multiple chromosomes in every species that has been examined.

scholarly journals AGE OF THE HOST AND OTHER FACTORS AFFECTING THE PRODUCTION WITH URETHANE OF PULMONARY ADENOMAS IN MICE

1951 ◽  
Vol 93 (5) ◽  
pp. 427-449 ◽  
Author(s):  
Stanfield Rogers
Keyword(s):  
Age Differences ◽  
Proliferative Activity ◽  
Major Part ◽  
Inverse Correlation ◽  
Alveolar Cells ◽  
Pulmonary Tissue ◽  
Factors Affecting ◽  
Neoplastic Change ◽  
Nuclear Changes ◽  
Old Mice

Young, rapidly growing mice are greatly more responsive to the adenoma-inducing influence of urethane than are those just arriving at maturity. This is manifest both in the proportion of animals developing the tumors and in their number per individual. An amount of urethane per gram body weight which suffices to induce adenomas in only an occasional 8-week-old animal will cause them to appear in quantity in more than half the 3-week-old mice injected. There is an almost absolute inverse correlation between the rate of growth of the pulmonary tissue between the ages of 2 and 10 weeks and the response to urethane in terms of adenomas. Hence the conclusion seems justified that the natural proliferative activity of the alveolar cells during youth plays a major part in the formation of the tumors. After the 6th week the age differences become relatively slight, yet there is reason to think that they continue in some degree as life goes on. Urethane has no effect to promote multiplication of the cells it has rendered neoplastic, its whole role being to initiate neoplastic change. The abnormalities induced by urethane in the nucleus of normal and neoplastic cells, as observed by previous workers, have suggested that the substance brings about the adenomatous state by acting upon the nucleus. But colchicine, also a karyolytic poison causing pronounced nuclear changes, does not alter in the least the yield of adenomas to urethane when administered concurrently. Nor does fasting influence the yield, though it markedly reduces mitotic activity. The meaning of these facts is discussed.

Cellular Oncogenes and Retroviruses

1983 ◽  
Vol 52 (1) ◽  
pp. 301-354 ◽  
Author(s):  
J M Bishop
Keyword(s):  
Cellular Oncogenes
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