Myocardial Adaptation and Autophagy

2012 ◽  
pp. 415-432
Author(s):  
Dipak K. Das ◽  
Hannah R. Vasanthi
Keyword(s):  
Myocardial Adaptation

Myocardial adaptation and exercise performance in patients with pulmonary arterial hypertension assessed with patient-specific computer simulations

2021 ◽  
Vol 321 (5) ◽  
pp. H865-H880
Author(s):  
Niels Thue Olsen ◽  
Christoffer Göransson ◽  
Niels Vejlstrup ◽  
Jørn Carlsen
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Computer Simulations ◽  
Patient Specific ◽  
Limiting Factor ◽  
Myocardial Mechanics ◽  
Use Of Data ◽  
Pulmonary Arterial ◽  
Myocardial Adaptation ◽  
Rest And Exercise

Computer simulations of the myocardial mechanics and hemodynamics of rest and exercise were performed in nine patients with pulmonary arterial hypertension and 10 control subjects, with the use of data from invasive catheterization and from cardiac magnetic resonance. This approach allowed a detailed analysis of myocardial adaptation to pulmonary arterial hypertension and showed how reduction in right ventricular inotropic reserve is the important limiting factor for an increase in cardiac output during exercise.

scholarly journals Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia

1996 ◽  
Vol 271 (6) ◽  
pp. H2300-H2305
Author(s):  
G. Merati ◽  
S. Allibardi ◽  
L. D. Monti ◽  
J. W. de Jong ◽  
M. Samaja
Keyword(s):  
Low Flow ◽  
Control Performance ◽  
Perfusion Medium ◽  
Atp Production ◽  
Lactate Release ◽  
Rat Hearts ◽  
O2 Supply ◽  
Developed Pressure ◽  
Myocardial Adaptation ◽  
Isolated Rat

We investigated whether one or more factors control performance in O2-limited hearts. For this purpose, we measured the dynamics of myocardial adaptation to reduced O2 supply with a specially designed setup, analyzing early changes after reduction in either flow of the perfusion medium or its PO2. For 10 min, 38 isolated rat hearts underwent low-flow ischemia or hypoxemia, matched for O2 supply. Early during ischemia, developed pressure declined at a rate of 311 +/- 25 mmHg/s; lactate release increased and then leveled off to 3.4 +/- 0.7 mumol/min within 2 min. During hypoxemia, pressure dropped initially, as observed during ischemia. However, it then increased before slowly decreasing. Lactate release during hypoxemia peaked at 13.0 +/- 2.3 mumol/min after 2 min, leveling off to 3.5 +/- 1.3 mumol/min. Glycogen decreased by 52 and 81% in ischemic and hypoxemic hearts, respectively (P < 0.05). Reexposure to ischemia or hypoxemia induced comparable changes in both groups. We conclude that, at the beginning of ischemia, a single factor does limit myocardial performance. This variable, which remains undisturbed for 10 min, is presumably O2 availability. In contrast, approximately 20 s after induction of hypoxemia, glycolytic ATP production can partially override low O2 availability by providing most of the energy needed. During repeated restriction of O2 supply, O2 availability alone limits performance during both ischemia and hypoxemia.

Myocardial Adaptation and Weight Fluctuation in College Wrestlers

1994 ◽  
Vol 15 (02) ◽  
pp. 70-73 ◽  
Author(s):  
S. Smith ◽  
R. Humphrey ◽  
J. Wohlford ◽  
D. Flint
Keyword(s):  
Weight Fluctuation ◽  
Myocardial Adaptation

Preconditioning Potentiates Molecular Signaling for Myocardial Adaptation to Ischemia

1996 ◽  
Vol 793 (1 Myocardial Pr) ◽  
pp. 191-209 ◽  
Author(s):  
DIPAK K. DAS ◽  
NILANJANA MAULIK ◽  
TETSUYA YOSHIDA ◽  
RICHARD M. ENGELMAN ◽  
YOU-LI ZU
Keyword(s):  
Molecular Signaling ◽  
Myocardial Adaptation

scholarly journals AMP Activated Protein Kinase Is Indispensable for Myocardial Adaptation to Caloric Restriction in Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59682 ◽  
Author(s):  
Kai Chen ◽  
Satoru Kobayashi ◽  
Xianmin Xu ◽  
Benoit Viollet ◽  
Qiangrong Liang
Keyword(s):  
Protein Kinase ◽  
Caloric Restriction ◽  
Amp Activated Protein Kinase ◽  
Myocardial Adaptation

Signal Transduction Pathway Leading to Hsp27 and Hsp70 Gene Expression during Myocardial Adaptation to Stressa

1998 ◽  
Vol 851 (1 STRESS OF LIF) ◽  
pp. 129-138 ◽  
Author(s):  
DIPAK K. DAS ◽  
NILANJANA MAULIK ◽  
RICHARD M. ENGELMAN ◽  
JOHN A. ROUSOU ◽  
DAVID DEATON ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Hsp70 Gene ◽  
Transduction Pathway ◽  
Myocardial Adaptation

Myocardial adaptation and efficiency in response to intensive physical training in elite speedskaters

2008 ◽  
Vol 126 (3) ◽  
pp. 346-351 ◽  
Author(s):  
Kian-Keong Poh ◽  
Thanh-Thao Ton-Nu ◽  
Tomas G. Neilan ◽  
Francois B. Tournoux ◽  
Michael H. Picard ◽  
...  
Keyword(s):  
Physical Training ◽  
Myocardial Adaptation

Myocardial adaptation in different endurance sports: an echocardiographic study

2004 ◽  
Vol 20 (1) ◽  
pp. 19-26 ◽  
Author(s):  
J. Hoogsteen ◽  
A. Hoogeveen ◽  
H. Schaffers ◽  
P.F.F. Wijn ◽  
N.M. van Hemel ◽  
...  
Keyword(s):  
Endurance Sports ◽  
Echocardiographic Study ◽  
Myocardial Adaptation
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