Molecular Aspects of Obesity and Insulin Resistance in Metabolic Syndrome and Neurological Disorders

2013 ◽  
pp. 143-189
Author(s):  
Akhlaq A. Farooqui
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Neurological Disorders ◽  
Molecular Aspects

scholarly journals Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Sandro M. Hirabara ◽  
Renata Gorjão ◽  
Marco A. Vinolo ◽  
Alice C. Rodrigues ◽  
Renato T. Nachbar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Molecular Basis ◽  
Insulin Action ◽  
Molecular Targets ◽  
Two Factors ◽  
Molecular Aspects

Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and the molecular aspects on inflammatory pathways interfering in insulin action. Moreover, we explore interventions based on molecular targets for preventing or treating correlated disorders, advances for a better characterization, and understanding of the mechanisms and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions.

Metabolic Syndrome and Prediabetes Fail to Detect a High Prevalence of Early Insulin Resistance—The PREMIER Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1534-P
Author(s):  
DAVID P. CISTOLA ◽  
ALOK K. DWIVEDI ◽  
JAMY D. ARD
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Prevalence

The Different Effect of Sucrose on Transcriptomic Profile in Adipose and Muscle Tissues in Model of Metabolic Syndrome and Insulin Resistance

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1722-P
Author(s):  
MARTINA HÜTTL ◽  
IRENA MARKOVÁ ◽  
HANA MALINSKA ◽  
LUDMILA KAZDOVA ◽  
ONDREJ SEDA
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Transcriptomic Profile ◽  
Muscle Tissues

Metabolic Syndrome During Menopause

2019 ◽  
Vol 17 (6) ◽  
pp. 595-603 ◽  
Author(s):  
Sezcan Mumusoglu ◽  
Bulent Okan Yildiz
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Central Obesity ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Natural Menopause ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Aging Women

The metabolic syndrome (MetS) comprises individual components including central obesity, insulin resistance, dyslipidaemia and hypertension and it is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The menopause per se increases the incidence of MetS in aging women. The effect(s) of menopause on individual components of MetS include: i) increasing central obesity with changes in the fat tissue distribution, ii) potential increase in insulin resistance, iii) changes in serum lipid concentrations, which seem to be associated with increasing weight rather than menopause itself, and, iv) an association between menopause and hypertension, although available data are inconclusive. With regard to the consequences of MetS during menopause, there is no consistent data supporting a causal relationship between menopause and CVD. However, concomitant MetS during menopause appears to increase the risk of CVD. Furthermore, despite the data supporting the association between early menopause and increased risk of T2DM, the association between natural menopause itself and risk of T2DM is not evident. However, the presence and the severity of MetS appears to be associated with an increased risk of T2DM. Although the mechanism is not clear, surgical menopause is strongly linked with a higher incidence of MetS. Interestingly, women with polycystic ovary syndrome (PCOS) have an increased risk of MetS during their reproductive years; however, with menopausal transition, the risk of MetS becomes similar to that of non-PCOS women.

C-Peptide and its Correlation to Parameters of Insulin Resistance in the Metabolic Syndrome

2011 ◽  
Vol 10 (8) ◽  
pp. 921-927 ◽  
Author(s):  
Shaheena Banu ◽  
Nasimudeen R. Jabir ◽  
C. N. Manjunath ◽  
Shazi Shakil ◽  
Mohammad A. Kamal
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
C Peptide ◽  
The Metabolic Syndrome

scholarly journals Metabolic Syndrome and Insulin Resistance in Schoolchildren From a Developing Country

2020 ◽  
Vol 7 ◽  
Author(s):  
Rashmi Ranjan Das ◽  
Manaswini Mangaraj ◽  
Sandeep Kumar Panigrahi ◽  
Amit Kumar Satapathy ◽  
Samarendra Mahapatro ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Developing Country
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