Primo Vascular System and Its Potential Role in Cancer Metastasis

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

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Lymphangiogenesis in development and disease

Thrombosis and Haemostasis ◽

10.1160/th07-04-0238 ◽

2007 ◽

Vol 98 (08) ◽

pp. 304-310 ◽

Cited By ~ 27

Author(s):

Ruediger Liersch ◽

Michael Detmar

Keyword(s):

Lymph Nodes ◽

Cancer Metastasis ◽

Lymphatic System ◽

Vascular System ◽

Malignant Tumors ◽

Inflammatory Diseases ◽

Transplant Rejection ◽

Lymphatic Vessels ◽

Lipid Uptake ◽

Molecular Control

SummaryThe lymphatic vascular system plays an important role in the maintenance of fluid homeostasis, in the afferent immune response, in the intestinal lipid uptake and in the metastatic spread of malignant cells. The recent discovery of specific markers and growth factors for lymphatic endothelium and the establishment of genetic mouse models with impairment of lymphatic function have provided novel insights into the molecular control of the lymphatic system in physiology and in embryonic development. They have also identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Moreover, the lymphatic system plays a major role in chronic inflammatory diseases and in transplant rejection. Importantly, malignant tumors can directly promote lymphangiogenesis within the primary tumor and in draining lymph nodes, leading to enhanced cancer metastasis to lymph nodes and beyond. Based upon these findings, novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.

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Abstract 2001: GATA2: Potential role as a prostate cancer metastasis-driving gene

10.1158/1538-7445.am2014-2001 ◽

2014 ◽

Author(s):

Yan Ting Chiang ◽

Kendric Wang ◽

Francesco Crea ◽

Colin Collins ◽

Peter Gout ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Metastasis ◽

Potential Role ◽

Prostate Cancer Metastasis

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Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System

Cells ◽

10.3390/cells9081875 ◽

2020 ◽

Vol 9 (8) ◽

pp. 1875

Author(s):

Cho-Ming Chao ◽

Lei Chong ◽

Xuran Chu ◽

Amit Shrestha ◽

Judith Behnke ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Signaling Pathway ◽

Preterm Infants ◽

Bronchopulmonary Dysplasia ◽

Potential Role ◽

Vascular System ◽

Point Of View ◽

Pulmonary Vasculature ◽

Curative Therapy

More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.

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Breast cancer metastasis through the lympho-vascular system

Clinical & Experimental Metastasis ◽

10.1007/s10585-018-9902-1 ◽

2018 ◽

Vol 35 (5-6) ◽

pp. 443-454 ◽

Cited By ~ 6

Author(s):

S. David Nathanson ◽

David Krag ◽

Henry M. Kuerer ◽

Lisa A. Newman ◽

Markus Brown ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Metastasis ◽

Vascular System ◽

Breast Cancer Metastasis

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Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis

Frontiers in Molecular Biosciences ◽

10.3389/fmolb.2021.661516 ◽

2021 ◽

Vol 8 ◽

Author(s):

Rami Mustapha ◽

Kenrick Ng ◽

James Monypenny ◽

Tony Ng

Keyword(s):

Antitumor Immunity ◽

Cancer Metastasis ◽

Potential Role ◽

Cancer Invasiveness ◽

Tertiary Lymphoid Structures ◽

Lymphoid Structures ◽

Cancer Dissemination ◽

Alternative Routes ◽

Biomechanical Factors

Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature. TLS neogenesis in cancer is highly varied and tissue dependent. The role of TLS in adaptive antitumor immunity is of great interest. However, data also show that TLS can play a role in cancer metastasis. The importance of lymphatics in cancer distant metastasis is clear yet the precise detail of how various immunosurveillance mechanisms interplay within TLS and/or draining LN is still under investigation. As part of the tumor lymphatics, TLS vasculature can provide alternative routes for the establishment of the pre-metastatic niche and cancer dissemination. The nature of the cytokine and chemokine signature at the heart of TLS induction can be key in determining the success of antitumor immunity or in promoting cancer invasiveness. Understanding the biochemical and biomechanical factors underlying TLS formation and the resulting impact on the primary tumor will be key in deciphering cancer metastasis and in the development of the next generation of cancer immunotherapeutics.

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