Aging and Dietary Lipids Modulate Ca2+-Dependent Mitochondrial Function in the Post-Ischemic Heart

2003 ◽  
pp. 73-82
Author(s):  
Salvatore Pepe
Keyword(s):  
Mitochondrial Function ◽  
Dietary Lipids ◽  
Ischemic Heart

Abstract 306: DJ-1 Preserves Mitochondrial Function in the Ischemic Heart by Reducing the Glycation of Complex I

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Yvanna Pantner ◽  
Yuuki Shimizu ◽  
Rohini Polavarapu ◽  
Lian Li ◽  
Lih-Shen Chin ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Complex I ◽  
Ischemic Heart

scholarly journals STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

2018 ◽  
Vol 238 (3) ◽  
pp. 187-202 ◽  
Author(s):  
Silva Sütt ◽  
Emmelie Cansby ◽  
Alexandra Paul ◽  
Manoj Amrutkar ◽  
Esther Nuñez-Durán ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mitochondrial Function ◽  
Oxidative Capacity ◽  
Dietary Lipids ◽  
Lipid Storage ◽  
Whole Body ◽  
Mitochondrial Activity ◽  
Metabolic Efficiency ◽  
High Fat ◽  
Inflammatory Infiltration

Whole-body energy homeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in non-adipose tissue and systemic insulin resistance in the context of nutritional stress. Here, we investigated the role of STK25 in regulation of adipose tissue dysfunction in mice challenged with a high-fat diet. We found that overexpression of STK25 in high-fat-fed mice resulted in impaired mitochondrial function and aggravated hypertrophy, inflammatory infiltration and fibrosis in adipose depots. Reciprocally, Stk25-knockout mice displayed improved mitochondrial function and were protected against diet-induced excessive fat storage, meta-inflammation and fibrosis in brown and white adipose tissues. Furthermore, in rodent HIB-1B cell line, STK25 depletion resulted in enhanced mitochondrial activity and consequently, reduced lipid droplet size, demonstrating an autonomous action for STK25 within adipocytes. In summary, we provide the first evidence for a key function of STK25 in controlling the metabolic balance of lipid utilization vs lipid storage in brown and white adipose depots, suggesting that repression of STK25 activity offers a potential strategy for establishing healthier adipose tissue in the context of chronic exposure to dietary lipids.

scholarly journals Maternal intake of trans-unsaturated or interesterified fatty acids during pregnancy and lactation modifies mitochondrial bioenergetics in the liver of adult offspring in mice

2017 ◽  
Vol 118 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Patricia C. de Velasco ◽  
Gustavo Chicaybam ◽  
Dionizio M. Ramos-Filho ◽  
Raísa M. A. R. dos Santos ◽  
Caroline Mairink ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Palm Oil ◽  
Mitochondrial Function ◽  
Plasma Glucose ◽  
Unsaturated Fatty Acids ◽  
Dietary Lipids ◽  
Adult Offspring ◽  
Mitochondrial Bioenergetics ◽  
Pregnancy And Lactation ◽  
Interesterified Fat

AbstractThe quality of dietary lipids in the maternal diet can programme the offspring to diseases in later life. We investigated whether the maternal intake of palm oil or interesterified fat, substitutes for trans-unsaturated fatty acids (FA), induces metabolic changes in the adult offspring. During pregnancy and lactation, C57BL/6 female mice received normolipidic diets containing partially hydrogenated vegetable fat rich in trans-unsaturated fatty acids (TG), palm oil (PG), interesterified fat (IG) or soyabean oil (CG). After weaning, male offspring from all groups received the control diet until day 110. Plasma glucose and TAG and liver FA profiles were ascertained. Liver mitochondrial function was accessed with high-resolution respirometry by measuring VO2, fluorimetry for detection of hydrogen peroxide (H2O2) production and mitochondrial Ca2+ uptake. The results showed that the IG offspring presented a 20 % increase in plasma glucose and both the IG and TG offspring presented a 2- and 1·9-fold increase in TAG, respectively, when compared with CG offspring. Liver MUFA and PUFA contents decreased in the TG and IG offspring when compared with CG offspring. Liver MUFA content also decreased in the PG offspring. These modifications in FA composition possibly affected liver mitochondrial function, as respiration was impaired in the TG offspring and H2O2 production was higher in the IG offspring. In addition, mitochondrial Ca2+ retention capacity was reduced by approximately 40 and 55 % in the TG and IG offspring, respectively. In conclusion, maternal consumption of trans-unsaturated and interesterified fat affected offspring health by compromising mitochondrial bioenergetics and lipid metabolism in the liver.

Rigorous swim training impairs mitochondrial function in post-ischaemic rat heart

1997 ◽  
Vol 160 (1) ◽  
pp. 139-148
Author(s):  
S.B. LEICHTWEIS ◽  
C. LEEUWENBURGH ◽  
D. J. PARMELEE ◽  
R. FIEBIG ◽  
L. L. JI
Keyword(s):  
Mitochondrial Function ◽  
Rat Heart

Residual hepatic mitochondrial function assessment through 13C-methionine, 13C-octanoate and 13C-ketoisocaproate breath tests

2001 ◽  
Vol 120 (5) ◽  
pp. A566-A566
Author(s):  
A ARMUZZI ◽  
M ZOCCO ◽  
M CANDELLI ◽  
C DICAMPLI ◽  
E NISTA ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Breath Tests ◽  
Function Assessment

245 NT-proBNP diagnostic value for diagnosis of isolated diastolic LV dysfunction in ischemic heart disease

2006 ◽  
Vol 5 (1) ◽  
pp. 51-51
Author(s):  
K WITA ◽  
A FILIPECKI ◽  
Z TABOR ◽  
W WROBEL ◽  
M NOWAK ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Diagnostic Value ◽  
Ischemic Heart ◽  
Lv Dysfunction
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