Vector-Encoded Interleukin-5 and Interleukin-6 Enhance Specific Mucosal Immunoglobulin a Reactivity In Vivo

1995 ◽  
pp. 35-42 ◽  
Author(s):  
Alistair J. Ramsay
Keyword(s):  
Interleukin 6 ◽  
Immunoglobulin A ◽  
Interleukin 5

scholarly journals Porcine Milk-Derived Small Extracellular Vesicles Promote Intestinal Immunoglobulin Production through pIgR

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1522
Author(s):  
Bin Zeng ◽  
Hailong Wang ◽  
Junyi Luo ◽  
Meiying Xie ◽  
Zhengjiang Zhao ◽  
...  
Keyword(s):  
Small Intestine ◽  
Extracellular Vesicles ◽  
Immunoglobulin A ◽  
Luciferase Reporter ◽  
Epithelial Cell Line ◽  
Intestinal Immunity ◽  
In Vivo Experiments ◽  
Porcine Milk

Secretory immunoglobulin A (SIgA) plays an important role in gut acquired immunity and mucosal homeostasis. Breast milk is the irreplaceable nutritional source for mammals after birth. Current studies have shown the potential functional role of milk-derived small extracellular vesicles (sEVs) and their RNAs cargo in intestinal health and immune regulation. However, there is a lack of studies to demonstrate how milk-derived sEVs affect intestinal immunity in recipient. In this study, through in vivo experiments, we found that porcine milk small extracellular vesicles (PM-sEVs) promoted intestinal SIgA levels, and increased the expression levels of polymeric immunoglobulin receptor (pIgR) both in mice and piglet. We examined the mechanism of how PM-sEVs increased the expression level of pIgR in vitro by using a porcine small intestine epithelial cell line (IPEC-J2). Through bioinformatics analysis, dual-luciferase reporter assays, and overexpression or knockdown of the corresponding non-coding RNAs, we identified circ-XPO4 in PM-sEVs as a crucial circRNA, which leads to the expression of pIgR via the suppression of miR-221-5p in intestinal cells. Importantly, we also observed that oral administration of PM-sEVs increased the level of circ-XPO4 and decreased the level of miR-221-5p in small intestine of piglets, indicating that circRNAs in milk-derived sEVs act as sponge for miRNAs in recipients. This study, for the first time, reveals that PM-sEVs have a capacity to stimulate intestinal SIgA production by delivering circRNAs to receptors and sponging the recipient’s original miRNAs, and also provides valuable data for insight into the role and mechanism of animal milk sEVs in intestinal immunity.

The Effect of Interleukin-6 on Pituitary Hormone Release in vivo and in vitro

1991 ◽  
Vol 54 (3) ◽  
pp. 262-266 ◽  
Author(s):  
Krzysztof Lyson ◽  
Samuel M. McCann
Keyword(s):  
Interleukin 6 ◽  
Pituitary Hormone ◽  
Hormone Release

scholarly journals Massive gliosis induced by interleukin‐6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

2009 ◽  
Vol 24 (2) ◽  
pp. 548-559 ◽  
Author(s):  
Paramita Chakrabarty ◽  
Karen Jansen‐West ◽  
Amanda Beccard ◽  
Carolina Ceballos‐Diaz ◽  
Yona Levites ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Driving Force ◽  
Amyloid Deposition

scholarly journals Enhancement of the Specific Mucosal Iga Response In Vivo by Interleukin-5 Expressed by an Attenuated Strain of Salmonella Serotype Dublin

1997 ◽  
Vol 46 (12) ◽  
pp. 1029-1038 ◽  
Author(s):  
B. L. Whittle ◽  
R. M. Smith ◽  
K. I. Matthaei ◽  
I. G. Young ◽  
N. K. Verma
Keyword(s):  
Interleukin 5 ◽  
Iga Response ◽  
Salmonella Serotype

Serum Levels of Interleukin 4, Interleukin 6 and Interferon-Gamma following in vivo Isotype-Specific Activation of IgE Synthesis in Humans

1991 ◽  
Vol 96 (1) ◽  
pp. 92-94 ◽  
Author(s):  
Yuri S. Lebedin ◽  
Ludmila A. Raudla ◽  
Alexandre G. Chuchalin
Keyword(s):  
Interferon Gamma ◽  
Interleukin 6 ◽  
Serum Levels ◽  
Interleukin 4 ◽  
Ige Synthesis

scholarly journals α1A-Adrenergic Receptors Regulate Cardiac Hypertrophy In Vivo Through Interleukin-6 Secretion

2013 ◽  
Vol 83 (5) ◽  
pp. 939-948 ◽  
Author(s):  
Robert S. Papay ◽  
Ting Shi ◽  
Michael T. Piascik ◽  
Sathyamangla V. Naga Prasad ◽  
Dianne M. Perez
Keyword(s):  
Cardiac Hypertrophy ◽  
Interleukin 6 ◽  
Adrenergic Receptors

scholarly journals CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Zafar Mahmood ◽  
Khalid Muhammad ◽  
Marc Schmalzing ◽  
Petra Roll ◽  
Thomas Dörner ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cells ◽  
Interleukin 6 ◽  
Memory B Cells ◽  
Interleukin 6 Receptor
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