Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium

1995 ◽  
pp. 5-12
Author(s):  
Gilbert L. Kukielka ◽  
Keith A. Youker ◽  
Lloyd H. Michael ◽  
Ajith G. Kumar ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Ischemic Myocardium ◽  
Early Reperfusion

Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium

1995 ◽  
Vol 147 (1-2) ◽  
pp. 5-12 ◽  
Author(s):  
Gilbert L. Kukielka ◽  
Keith A. Youker ◽  
Lloyd H. Michael ◽  
Ajith G. Kumar ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Ischemic Myocardium ◽  
Early Reperfusion

Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell Disease

Hematology ◽  
2007 ◽  
Vol 2007 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Marilyn J. Telen
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Adhesion Molecules ◽  
Sickle Cell ◽  
Vascular Endothelium ◽  
Blood Cells ◽  
Cell Disease ◽  
Adhesive Interactions ◽  
Lines Of Evidence

AbstractA number of lines of evidence now support the hypothesis that vaso-occlusion and several of the sequelae of sickle cell disease (SCD) arise, at least in part, from adhesive interactions of sickle red blood cells, leukocytes, and the endothelium. Both experimental and genetic evidence provide support for the importance of these interactions. It is likely that future therapies for SCD might target one or more of these interactions.

P.1.a.012 New insights from cell adhesion molecules in antidepressant action: role of ITGB3 and GAP43 genes

2014 ◽  
Vol 24 ◽  
pp. S160
Author(s):  
C. Fabbri ◽  
C. Crisafulli ◽  
D. Gurwitz ◽  
J. Stingl ◽  
R. Calati ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Antidepressant Action

scholarly journals Role of adhesion molecules in the induction of restenosis after angioplasty in the lower limb

2006 ◽  
Vol 43 (5) ◽  
pp. 969-977 ◽  
Author(s):  
Peter Heider ◽  
Moritz Georg Wildgruber ◽  
Wolfgang Weiss ◽  
Hermann Jakob Berger ◽  
Eckstein Hans Henning ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Lower Limb

Role of Adhesion Molecules in Natural Killer Cell-Induced DNA Fragmentation of Cytomegalovirus-Infected Fibroblasts

1996 ◽  
Vol 9 (4) ◽  
pp. 219-224 ◽  
Author(s):  
MASAHIRO ITO ◽  
MASAHIRO WATANABE ◽  
HITOSHI KAMIYA ◽  
MINORU SAKURAI
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Adhesion Molecules ◽  
Dna Fragmentation ◽  
Killer Cell

scholarly journals Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice

2011 ◽  
Vol 300 (5) ◽  
pp. L781-L789 ◽  
Author(s):  
Szabolcs Bertok ◽  
Michael R. Wilson ◽  
Anthony D. Dorr ◽  
Justina O. Dokpesi ◽  
Kieran P. O'Dea ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Adhesion Molecules ◽  
Surface Expression ◽  
Tnf Receptor ◽  
Wild Type ◽  
Tnf Receptors ◽  
Pulmonary Endothelial Cells ◽  
Microvascular Inflammation

TNF plays a crucial role in the pathogenesis of acute lung injury. However, the expression profile of its two receptors, p55 and p75, on pulmonary endothelium and their influence on TNF signaling during lung microvascular inflammation remain uncertain. Using flow cytometry, we characterized the expression profile of TNF receptors on the surface of freshly harvested pulmonary endothelial cells (PECs) from mice and found expression of both receptors with dominance of p55. To investigate the impact of stimulating individual TNF receptors, we treated wild-type and TNF receptor knockout mice with intravenous TNF and determined surface expression of adhesion molecules (E-selectin, VCAM-1, ICAM-1) on PECs by flow cytometry. TNF-induced upregulation of all adhesion molecules was substantially attenuated by absence of p55, whereas lack of p75 had a similar but smaller effect that varied between adhesion molecules. Selective blockade of individual TNF receptors by specific antibodies in wild-type primary PEC culture confirmed that the in vivo findings were due to direct effects of TNF receptor inhibition on endothelium and not other cells (e.g., circulating leukocytes). Finally, we found that PEC surface expression of p55 dramatically decreased in the early stages of endotoxemia following intravenous LPS, while no change in p75 expression was detected. These data demonstrate a crucial in vivo role of p55 and an auxiliary role of p75 in TNF-mediated adhesion molecule upregulation on PECs. It is possible that the importance of the individual receptors varies at different stages of pulmonary microvascular inflammation following changes in their relative expression.

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