scholarly journals Role of adhesion molecules in the induction of restenosis after angioplasty in the lower limb

2006 ◽  
Vol 43 (5) ◽  
pp. 969-977 ◽  
Author(s):  
Peter Heider ◽  
Moritz Georg Wildgruber ◽  
Wolfgang Weiss ◽  
Hermann Jakob Berger ◽  
Eckstein Hans Henning ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Lower Limb

The role of delayed lower limb embolectomy in patients with late ischemia

Chirurgia ◽  
2020 ◽  
Vol 32 (6) ◽  
Author(s):  
Walid M. Gamal ◽  
Abdrheem F. Mohamed ◽  
Zeniab M. Askary
Keyword(s):  
Lower Limb

scholarly journals The Role of Circulating Biomarkers in Peripheral Arterial Disease

2021 ◽  
Vol 22 (7) ◽  
pp. 3601
Author(s):  
Goren Saenz-Pipaon ◽  
Esther Martinez-Aguilar ◽  
Josune Orbe ◽  
Arantxa González Miqueo ◽  
Leopoldo Fernandez-Alonso ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Lower Limb ◽  
Prediction Models ◽  
Arterial Disease ◽  
Cardiac Damage ◽  
Thrombotic Occlusion ◽  
Medical Treatments ◽  
Peripheral Arterial ◽  
Inflammatory Molecules

Peripheral arterial disease (PAD) of the lower extremities is a chronic illness predominantly of atherosclerotic aetiology, associated to traditional cardiovascular (CV) risk factors. It is one of the most prevalent CV conditions worldwide in subjects >65 years, estimated to increase greatly with the aging of the population, becoming a severe socioeconomic problem in the future. The narrowing and thrombotic occlusion of the lower limb arteries impairs the walking function as the disease progresses, increasing the risk of CV events (myocardial infarction and stroke), amputation and death. Despite its poor prognosis, PAD patients are scarcely identified until the disease is advanced, highlighting the need for reliable biomarkers for PAD patient stratification, that might also contribute to define more personalized medical treatments. In this review, we will discuss the usefulness of inflammatory molecules, matrix metalloproteinases (MMPs), and cardiac damage markers, as well as novel components of the liquid biopsy, extracellular vesicles (EVs), and non-coding RNAs for lower limb PAD identification, stratification, and outcome assessment. We will also explore the potential of machine learning methods to build prediction models to refine PAD assessment. In this line, the usefulness of multimarker approaches to evaluate this complex multifactorial disease will be also discussed.

Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell Disease

Hematology ◽  
2007 ◽  
Vol 2007 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Marilyn J. Telen
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Adhesion Molecules ◽  
Sickle Cell ◽  
Vascular Endothelium ◽  
Blood Cells ◽  
Cell Disease ◽  
Adhesive Interactions ◽  
Lines Of Evidence

AbstractA number of lines of evidence now support the hypothesis that vaso-occlusion and several of the sequelae of sickle cell disease (SCD) arise, at least in part, from adhesive interactions of sickle red blood cells, leukocytes, and the endothelium. Both experimental and genetic evidence provide support for the importance of these interactions. It is likely that future therapies for SCD might target one or more of these interactions.

Bilateral asymmetries in professional cyclists during a Grand Tour

2020 ◽  
pp. 1-7
Author(s):  
Alejandro Javaloyes ◽  
Manuel Mateo-March ◽  
Felipe P. Carpes ◽  
Manuel Moya-Ramon ◽  
Raúl Lopez-Grueso ◽  
...  
Keyword(s):  
Injury Prevention ◽  
Intensity Distribution ◽  
Power Output ◽  
Lower Limb ◽  
Overuse Injury ◽  
Power Balance ◽  
Grand Tour ◽  
Race Time ◽  
Potential Link

BACKGROUND: Pedalling asymmetries are a topic of interest to cycling coaches and athletes due to a potential link with performance and injury prevention. OBJECTIVES: The aim of this study is to describe the bilateral asymmetry of professional cyclists during two editions of a Grand Tour. METHODS: Here we set out to determine the power balance (power produced by each lower limb) between stronger and weaker leg (dominant vs. non-dominant) of 12 UCI professional cyclists competing at two Giro d’Italia editions. Power data were recorded during competition stages. Further analysis considered power data clustered into individual intensity zones (from Z1 to Z7). RESULTS: Higher intensity elicited better power balance (lower asymmetry) regardless of the stage profile. Intensity distribution analysed according to the role of the cyclist was lower for climbers in Z2 (p= 0.006) and Z7 (p= 0.002) and higher in Z5 (p= 0.023) compared to team helpers. Power balance ranged from 0 to 9 % across the different athletes. CONCLUSIONS: Increase in power output improves power balance, especially in team helpers, and the lower power balance at lower exercise intensities, which are most of the race time, may elicit significant cumulative loading on a given leg of the cyclists, which requires further attention regarding risks of overuse injury.

P.1.a.012 New insights from cell adhesion molecules in antidepressant action: role of ITGB3 and GAP43 genes

2014 ◽  
Vol 24 ◽  
pp. S160
Author(s):  
C. Fabbri ◽  
C. Crisafulli ◽  
D. Gurwitz ◽  
J. Stingl ◽  
R. Calati ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Antidepressant Action

Role of Adhesion Molecules in Natural Killer Cell-Induced DNA Fragmentation of Cytomegalovirus-Infected Fibroblasts

1996 ◽  
Vol 9 (4) ◽  
pp. 219-224 ◽  
Author(s):  
MASAHIRO ITO ◽  
MASAHIRO WATANABE ◽  
HITOSHI KAMIYA ◽  
MINORU SAKURAI
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Adhesion Molecules ◽  
Dna Fragmentation ◽  
Killer Cell

scholarly journals Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice

2011 ◽  
Vol 300 (5) ◽  
pp. L781-L789 ◽  
Author(s):  
Szabolcs Bertok ◽  
Michael R. Wilson ◽  
Anthony D. Dorr ◽  
Justina O. Dokpesi ◽  
Kieran P. O'Dea ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Adhesion Molecules ◽  
Surface Expression ◽  
Tnf Receptor ◽  
Wild Type ◽  
Tnf Receptors ◽  
Pulmonary Endothelial Cells ◽  
Microvascular Inflammation

TNF plays a crucial role in the pathogenesis of acute lung injury. However, the expression profile of its two receptors, p55 and p75, on pulmonary endothelium and their influence on TNF signaling during lung microvascular inflammation remain uncertain. Using flow cytometry, we characterized the expression profile of TNF receptors on the surface of freshly harvested pulmonary endothelial cells (PECs) from mice and found expression of both receptors with dominance of p55. To investigate the impact of stimulating individual TNF receptors, we treated wild-type and TNF receptor knockout mice with intravenous TNF and determined surface expression of adhesion molecules (E-selectin, VCAM-1, ICAM-1) on PECs by flow cytometry. TNF-induced upregulation of all adhesion molecules was substantially attenuated by absence of p55, whereas lack of p75 had a similar but smaller effect that varied between adhesion molecules. Selective blockade of individual TNF receptors by specific antibodies in wild-type primary PEC culture confirmed that the in vivo findings were due to direct effects of TNF receptor inhibition on endothelium and not other cells (e.g., circulating leukocytes). Finally, we found that PEC surface expression of p55 dramatically decreased in the early stages of endotoxemia following intravenous LPS, while no change in p75 expression was detected. These data demonstrate a crucial in vivo role of p55 and an auxiliary role of p75 in TNF-mediated adhesion molecule upregulation on PECs. It is possible that the importance of the individual receptors varies at different stages of pulmonary microvascular inflammation following changes in their relative expression.

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