Lyme Borreliosis in Children

1994 ◽  
pp. 13-20
Author(s):  
Hans-Jürgen Christen ◽  
Folker Hanefeld ◽  
Helmut Eiffert ◽  
Reiner Thomssen
Keyword(s):  
Lyme Borreliosis

Lyme Borreliosis Can Rest on Clinical Findings

2007 ◽  
Vol 37 (3) ◽  
pp. 22
Author(s):  
John R. Bell
Keyword(s):  
Lyme Borreliosis ◽  
Clinical Findings

Multifactorial analysis of clinical laboratory signs, the levels of IL-17A, IL-23, IL-33, IL-35, and specific antibodies in the serum of patients with Lyme borreliosis without erythema migrans

2020 ◽  
Vol 4 (11) ◽  
pp. 676-681
Author(s):  
V.V. Sapozhnikova ◽  
◽  
A.L. Bondarenko ◽  
Keyword(s):  
Principal Component Analysis ◽  
Lyme Borreliosis ◽  
Clinical Laboratory ◽  
Acute Infection ◽  
Erythema Migrans ◽  
Principal Component ◽  
Component Analysis ◽  
Control Group ◽  
Multifactorial Analysis ◽  
Specific Antibodies

Aim: to determine the association between clinical laboratory parameters, the production of cytokines (IL-17A, -23, -33, -35), and specific IgM and IgG in the serum of patients with Lyme borreliosis without erythema migrans. Patients and Methods: complete blood count, the concentrations of IL-17A, -23, -33, -35, and the levels of specific IgM and IgG were measured during acute infection and convalescence (n=30). The control group included age- and sex-matched healthy individuals (n=30). Statistical analysis was performed using the StatSoft Statistica v 10.0 software (parametric and non-parametric methods and multifactorial analysis, i.e., principal component analysis). Results: most (80%) patients with Lyme borreliosis without erythema migrans are the people of working age. In most patients, the combination of the specific antibodies against Borrelia afzelii and Borrelia garinii (76.7%) and severe intoxication and inflammatory process (100%) were detected. Moderate and severe disease associated with meningism was diagnosed in 90% and 10%, respectively. The mean duration of hectic period was 8.3±1.27 days. Abnormal ECG was reported in 40% of patients, i.e., conduction abnormalities in 20%, sinus bradycardia in 16.7%,and sinus tachycardia in 3.3%. The clinical laboratory signs of hepatitis without jaundice were identified in 26.7%. During treatment, the significant reduction in band and segmented neutrophil counts as well as the significant increase in platelet count were revealed compared to these parameters at admission. Abnormal cytokine levels (i.e., the increase in IL-17A, -23, -33 and the deficiency of IL-35) were detected. Conclusions: multifactorial analysis has demonstrated that the severity of immunological abnormalities in patients with Lyme borreliosis without erythema migrans is associated with fever, cardiac and liver disorders, the high levels of IL-23 and IL-33, and the lack of IL-35 and specific IgM and IgG. KEYWORDS: tick-borne borreliosis, Lyme disease without erythema migrans, clinical laboratory signs, cytokines, specific antibodies, multifactorial analysis, principal component analysis. FOR CITATION: Sapozhnikova V.V., Bondarenko A.L. Multifactorial analysis of clinical laboratory signs, the levels of IL-17A, IL-23, IL-33, IL-35, and specific antibodies in the serum of patients with Lyme borreliosis without erythema migrans. Russian Medical Inquiry. 2020;4(11):676–681. DOI: 10.32364/2587-6821-2020-4-11-676-681.

Incompetence of Roe Deer as Reservoirs of the Lyme Borreliosis Spirochete

1992 ◽  
Vol 29 (5) ◽  
pp. 813-817 ◽  
Author(s):  
Thomas G. T. Jaenson ◽  
Lars Tälleklint
Keyword(s):  
Lyme Borreliosis ◽  
Roe Deer

scholarly journals Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mahdi Aminikhah ◽  
Jukka T. Forsman ◽  
Esa Koskela ◽  
Tapio Mappes ◽  
Jussi Sane ◽  
...  
Keyword(s):  
Population Dynamics ◽  
Lyme Borreliosis ◽  
Bank Vole ◽  
Myodes Glareolus ◽  
Northern Europe ◽  
Time Lags ◽  
Rodent Population ◽  
Vole Cycles ◽  
Infection Dynamics ◽  
Abundance Fluctuations

AbstractZoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole (Myodes glareolus) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags.

Lyme borreliosis in Finland in 1986–1988

1989 ◽  
Vol 43 (6) ◽  
pp. 427-430 ◽  
Author(s):  
K. Schauman ◽  
J. Kovanen ◽  
I. Seppälä
Keyword(s):  
Lyme Borreliosis

scholarly journals T Cells Exacerbate Lyme Borreliosis in TLR2-Deficient Mice

2016 ◽  
Vol 7 ◽  
Author(s):  
Carrie E. Lasky ◽  
Carmela L. Pratt ◽  
Kinsey A. Hilliard ◽  
John L. Jones ◽  
Charles R. Brown
Keyword(s):  
T Cells ◽  
Lyme Borreliosis ◽  
Deficient Mice
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