Capsaicin and Its Protective Effect Against UV-Induced Lipid Peroxidation on Liposomal Preparations

1993 ◽  
pp. 377-380
Author(s):  
A. K. De ◽  
J. J. Ghosh
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect

scholarly journals Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line

1999 ◽  
pp. 35-39 ◽  
Author(s):  
M Gallo ◽  
M Aragno ◽  
V Gatto ◽  
E Tamagno ◽  
E Brignardello ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect ◽  
Human Liver ◽  
Antioxidant Properties ◽  
Liver Cells ◽  
Threshold Concentration ◽  
Blue Staining ◽  
Lag Phase ◽  
Human Liver Cell ◽  
Chang Liver

OBJECTIVE: Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim was to evaluate whether its two opposed effects on lipid peroxidation reported in the literature may be dependent on schedule and doses used. METHODS: Chang liver cells, a line derived from normal human liver, were grown in media containing either no steroids (control) or DHEA at concentrations ranging from 0.1 micromol/l to 50 micromol/l. At specific times, cultures were halted and cells received a pro-oxidant stimulus (cumene (CuOOH) 0.5 mmol/l), at which time cell viability (by trypan blue staining and lactate dehydrogenase (LDH) release) and thiobarbituric acid reactive substances (TBARS) concentration (spectrophotometrical assay) were evaluated. RESULTS: At concentrations ranging from 0.1 micromol/l to 1 micromol/l, DHEA protects Chang liver cells against lipid peroxidation and/or death induced by cumene. This effect disappears if the concentration is increased to 10 micromol/l; at higher concentrations (50 micromol/l) a pro-oxidant/cytotoxic effect of DHEA appears. CONCLUSIONS: DHEA exhibits two opposed effects on lipid peroxidation; depending on its concentration it acts either to limit or to induce oxidative stress. The threshold concentration at which the pro-oxidant activity of DHEA prevails is not far in excess of that having an antioxidant effect. Either effect of DHEA on lipid peroxidation is only evident after a 'lag-phase'.

Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H2O2 induced lipid peroxidation in renal tubular epithelial cells

2008 ◽  
Vol 46 (9) ◽  
pp. 2984-2990 ◽  
Author(s):  
Monica Deiana ◽  
Alessandra Incani ◽  
Antonella Rosa ◽  
Giulia Corona ◽  
Angela Atzeri ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Epithelial Cells ◽  
Protective Effect ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular

Protective Effect of Carvedilol on Paracetamol-induced Hepatotoxicity; Role of Modulation Inflammation and Lipid Peroxidation

2016 ◽  
Vol 13 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Heba M. Mahmoud ◽  
Amira M. Abo-Yousse ◽  
Ali A. Abo-Saif
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect

scholarly journals Protective effect of benexate hydrochloride betadex against indomethacin-induced gastric lesions: Blockage of lipid peroxidation.

1994 ◽  
Vol 64 ◽  
pp. 279
Author(s):  
Takuji Mizui ◽  
Mikio Ogawa ◽  
Tohko Ryu ◽  
Junko Higaki ◽  
Kenji Miyata
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect ◽  
Gastric Lesions
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