Protective effect of panaxydol against repeated administration of aristolochic acid on renal function and lipid peroxidation products via activating Keap1‐Nrf2/ARE pathway in rat kidney

2020 ◽  
Author(s):  
Yinxue Guo ◽  
Maorong Hu ◽  
Juan Ma ◽  
Arunachalam Chinnathambi ◽  
Sulaiman Ali Alharbi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Renal Function ◽  
Protective Effect ◽  
Aristolochic Acid ◽  
Rat Kidney ◽  
Repeated Administration ◽  
Lipid Peroxidation Products

Acute lead exposure induces renal haeme oxygenase-1 and decreases urinary Na excretion

2003 ◽  
Vol 22 (5) ◽  
pp. 237-244 ◽  
Author(s):  
Hilda Vargas ◽  
Carlos Castillo ◽  
Francisco Posadas ◽  
Bruno Escalante
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Renal Function ◽  
Lead Exposure ◽  
Lead Acetate ◽  
Single Injection ◽  
Rat Kidney ◽  
Kidney Cortex ◽  
Tin Protoporphyrin ◽  
Pb Exposure

The effects of acute lead exposure on renal function, lipid peroxidation and the expression of haeme oxygenase (HO) in rat kidney were determined. A single injection of lead acetate (50 mg Pb/kg) was given to rats. Changes in renal function, characterized by a significant reduction in the Na excretion was observed six hours after Pb exposure; this effect persisted for 24 hours. TBARS levels increased in kidney cortex 24 hours after Pb administration. In kidney cortex, Pb exposure affected the expression of HO-1, a renal protein associated with oxidative stress. HO-1 mRNA increased 2.3-fold, three hours after Pb administration and remained increased for six, 12 and 24 hours. HO enzymatic activity and HO-1 protein increased six and three hours after Pb administration, respectively, and remained increased at 24 hours. HO inhibition by tin-protoporphyrin, potentiated Pb-induced increase in TBARS and prevented the Pb-induced reduction in Na excretion. Our data suggest that Pb may be acting through the generation of oxidant products and induction of HO.

scholarly journals PSVII-17 Program Chair Poster Pick: Reproductive function of cows depending on lipid metabolism

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 293-294
Author(s):  
Murat Baymishev ◽  
Sergey Eremin ◽  
Kirill Plemyashov ◽  
Khamidulla Baymishev ◽  
Igor Konopel’tsev ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Live Weight ◽  
Reproductive Function ◽  
Serum Levels ◽  
Total Serum ◽  
Dry Period ◽  
Lipid Peroxidation Products ◽  
Synthetic Function ◽  
The Difference ◽  
Oxidized Products

Abstract The aim of the study was to determine the etiopathogenesis of reproductive dysfunction in highly productive cows. Studies were conducted on cows of black-motley breed, aged 3–5 lactations, with a live weight of 480–520 kg. Cows were divided into two groups. The first group included 20 cows effective inseminated after the first insemination. The second group included 17 cows that did not fertilize after the first insemination. Blood samples (n = 253) were taken from 4–7; 14–17; 24–34; 35–50; 88–95; 195–210 days of pregnancy; during the beginning of dry period (DP); 1–4 days before calving and on the first day after calving. The content of total serum lipids in pregnant animals was 15.8% higher compared to unfertilized animals. In non-pregnant cows, a decrease in free cholesterol (by 28.65%), especially in its ether-bound fraction (14.91%), indicates a lower synthetic function of the liver, which is confirmed by the low serum levels of vitamins A and E (a difference of 11.3 and 23.65%). The DP was characterized by a significant increase in the products of lipid peroxidation - malondialdehyde by 12–17%, diene and triene conjugates - by 10–15 and 8–15%, respectively, and 1–4 days before calving in cows, which subsequently had a pathological calving, in particular - retention of placenta (5 cows), were characterized by an increased content in the blood plasma of lipid peroxidation products. Thus, the difference in the number of dienes, trienes, and malondialdehyde products was 14.0, 12.0, and 23.5%, compared with animals without obstetric pathology. On the first day after calving, this difference increased even more. Cows with retention of placenta had a significantly higher level of lipid peroxidation products and were characterized by a predominance of oxidized products over the antiradical thiol disulfide and ascorbate systems restored in the antioxidant balance.

scholarly journals Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 856
Author(s):  
Eun Young Kim ◽  
Stuart E. Dryer
Keyword(s):  
Renal Function ◽  
Protective Effect ◽  
Renal Fibrosis ◽  
Transient Receptor Potential ◽  
Smooth Muscle Actin ◽  
Receptor Potential ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Transient Receptor

Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in mice. Aging also evokes declines in renal function owing to effects on almost every renal compartment in humans and rodents. Here, we have examined the role of TRPC6 in driving inflammation and fibrosis during aging in Sprague-Dawley rats. This was assessed in rats with non-functional TRPC6 channels owing to CRISPR-Cas9 deletion of a portion of the ankyrin repeat domain required for the assembly of functional TRPC6 channels (Trpc6del/del rats). Wild-type littermates (Trpc6wt/wt rats) were used as controls. Animals were evaluated at 2 months and 12 months of age. There was no sign of kidney disease at 2 months of age, regardless of genotype. However, by 12 months of age, all rats examined showed declines in renal function associated with albuminuria, azotemia and increased urine excretion of β2–microglobulin, a marker for proximal tubule pathology. These changes were equally severe in Trpc6wt/wt and Trpc6del/del rats. We also observed age-related increases in renal cortical expression of markers of fibrosis (α-smooth muscle actin and vimentin) and inflammation (NLRP3 and pro-IL−1β), and there was no detectable protective effect of TRPC6 inactivation. Tubulointerstitial fibrosis assessed from histology also appeared equally severe in Trpc6wt/wt and Trpc6del/del rats. By contrast, glomerular pathology, blindly scored from histological sections, suggested a significant protective effect of TRPC6 inactivation, but only within the glomerular compartment.

scholarly journals Raised concentrations of aldehyde lipid peroxidation products in premature infants with chronic lung disease

1999 ◽  
Vol 80 (1) ◽  
pp. F21-F25 ◽  
Author(s):  
T. Ogihara ◽  
K. Hirano ◽  
T. Morinobu ◽  
H.-S. Kim ◽  
M. Hiroi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lung Disease ◽  
Premature Infants ◽  
Chronic Lung Disease ◽  
Lipid Peroxidation Products
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