Alzheimer%#x2019;s Disease and Genetically Engineered Animal Models

1999 ◽  
pp. 187-214
Author(s):  
David R. Borchelt ◽  
Philip C. Wong ◽  
Sangram S. Sisodia ◽  
Donald L. Price
Keyword(s):  
Animal Models ◽  
Genetically Engineered

scholarly journals Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications

2021 ◽  
Vol 8 (4) ◽  
pp. 59
Author(s):  
Elisabete Nascimento-Gonçalves ◽  
Bruno A.L. Mendes ◽  
Rita Silva-Reis ◽  
Ana I. Faustino-Rocha ◽  
Adelina Gama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Cancer Progression ◽  
Social Impact ◽  
Genetically Engineered ◽  
In Vivo Studies ◽  
Gastrointestinal Malignancies ◽  
Advantages And Disadvantages ◽  
Colon Cancer Progression

Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds’ effects on colorectal cancer.

scholarly journals Natriuretic peptide system: an overview of studies using genetically engineered animal models

FEBS Journal ◽  
2011 ◽  
Vol 278 (11) ◽  
pp. 1830-1841 ◽  
Author(s):  
Ichiro Kishimoto ◽  
Takeshi Tokudome ◽  
Kazuwa Nakao ◽  
Kenji Kangawa
Keyword(s):  
Animal Models ◽  
Natriuretic Peptide ◽  
Genetically Engineered ◽  
Peptide System ◽  
Natriuretic Peptide System

scholarly journals Animal models of colorectal peritoneal metastasis

2016 ◽  
Vol 1 (1) ◽  
pp. 23-43 ◽  
Author(s):  
Félix Gremonprez ◽  
Wouter Willaert ◽  
Wim Ceelen
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Peritoneal Carcinomatosis ◽  
Peritoneal Metastasis ◽  
Treatment Options ◽  
Genetically Engineered ◽  
Preclinical Research ◽  
Novel Treatment ◽  
Genetically Engineered Mice ◽  
Wide Range

AbstractColorectal cancer remains an important cause of mortality worldwide. The presence of peritoneal carcinomatosis (PC) causes significant symptoms and is notoriously difficult to treat. Therefore, informative preclinical research into the mechanisms and possible novel treatment options of colorectal PC is essential in order to improve the prognostic outlook in these patients. Several syngeneic and xenograft animal models of colorectal PC were established, studying a wide range of experimental procedures and substances. Regrettably, more sophisticated models such as those giving rise to spontaneous PC or involving genetically engineered mice are lacking. Here, we provide an overview of all reported colorectal PC animal models and briefly discuss their use, strengths, and limitations.

scholarly journals Emerging and Evolving Ovarian Cancer Animal Models

2015 ◽  
Vol 8s1 ◽  
pp. CGM.S21221 ◽  
Author(s):  
Alexander S. Bobbs ◽  
Jennifer M. Cole ◽  
Karen D. Cowden Dahl
Keyword(s):  
Ovarian Cancer ◽  
Animal Models ◽  
Mouse Models ◽  
Immune Cell ◽  
Treatment Options ◽  
The United States ◽  
Genetically Engineered ◽  
Response To Therapy ◽  
Gynecological Malignancy ◽  
Immunocompetent Mice

Ovarian cancer (OC) is the leading cause of death from a gynecological malignancy in the United States. By the time a woman is diagnosed with OC, the tumor has usually metastasized. Mouse models that are used to recapitulate different aspects of human OC have been evolving for nearly 40 years. Xenograft studies in immunocompromised and immunocompetent mice have enhanced our knowledge of metastasis and immune cell involvement in cancer. Patient-derived xenografts (PDXs) can accurately reflect metastasis, response to therapy, and diverse genetics found in patients. Additionally, multiple genetically engineered mouse models have increased our understanding of possible tissues of origin for OC and what role individual mutations play in establishing ovarian tumors. Many of these models are used to test novel therapeutics. As no single model perfectly copies the human disease, we can use a variety of OC animal models in hypothesis testing that will lead to novel treatment options. The goal of this review is to provide an overview of the utility of different mouse models in the study of OC and their suitability for cancer research.

scholarly journals Experimental models in the study of pathogenesis and the development of treatments for ovarian cancer (systematic review)

2021 ◽  
Vol 67 (4) ◽  
pp. 463-473
Author(s):  
Galina ZHUKOVA ◽  
Ekasterina Verenikina ◽  
Tatiana Protasova ◽  
Daria Yakubova ◽  
Anastasia Volkova
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Animal Models ◽  
Web Of Science ◽  
Ex Vivo ◽  
Primary Cultures ◽  
Genetically Engineered ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Immunodeficient Mice

A systematic review of modern methods of experimental study of ovarian cancer using traditional (immunocompetent, genetically engineered and immunodeficient) and non-traditional (that don’t belong to the mammals) animal models,established and primary cultures of human ovarian cancer, including three-dimensional organotypic spheroids (3D- models ex vivo) is presented. The prospects of the considered models for studying of the pathogenesis of various molecular-genetic and histological variants of ovarian cancer, as well as for developing methods of personalized treatment, are discussed. The limitations of modern animal models are indicated. The greatest attention is paid to studies on immunodeficient animals using xenografts based on established cultures of human ovarian cancer cells and on tumor tissue obtained directly from the patients (patient derived xenografts, PDX). The questions of various variants of xenograft transplantation with an emphasis on the problems of orthotopic transplantation of human ovarian cancer into immunodeficient mice and the relevance of methods for local humanization in heterotopic transplantation are considered. The most promising, from the point of the author’s view, approaches to studying the effectiveness of drug therapy for ovarian cancer in immunodeficient animal models are outlined. To prepare a systematic review, a literature search was carried out on the Scopus, Web of Science, Med Line, PubMed, Cyber Leninka, RSCI databases. The analysis used literature sources indexed in the Scopus and Web of Science databases (97%) and the RSCI. More than 60% of the works amount has been published over the past 5 years.

Genetically engineered animal models of Parkinson's disease: From worm to rodent

2019 ◽  
Vol 49 (4) ◽  
pp. 533-560 ◽  
Author(s):  
Ludivine S. Breger ◽  
Marie T. Fuzzati Armentero
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Genetically Engineered

Spontaneous and genetically engineered animal models

2004 ◽  
Vol 40 (6) ◽  
pp. 858-880 ◽  
Author(s):  
K Hansen ◽  
C Khanna
Keyword(s):  
Animal Models ◽  
Genetically Engineered

scholarly journals Humane Endpoints for Genetically Engineered Animal Models

ILAR Journal ◽  
2000 ◽  
Vol 41 (2) ◽  
pp. 94-98 ◽  
Author(s):  
M. B. Dennis
Keyword(s):  
Animal Models ◽  
Genetically Engineered
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