Local Ischemia as a Kininogen Depressant: Effect of Cortisone, Taurine and a Kallikrein Inhibitor

1970 ◽  
pp. 377-383 ◽  
Author(s):  
A. Bavazzano ◽  
N. Sidell ◽  
S. Michelacci ◽  
F. Sicuteri
Keyword(s):  
Depressant Effect ◽  
Kallikrein Inhibitor ◽  
Local Ischemia

Local ischemia as a kininogen depressant: Effect of cortisone, taurine and kallikrein inhibitor

1969 ◽  
Vol 1 (2) ◽  
pp. 137-138 ◽  
Author(s):  
A. Bavazzano ◽  
N. Sidell ◽  
S. Michelacci ◽  
F. Sicuteri
Keyword(s):  
Depressant Effect ◽  
Kallikrein Inhibitor ◽  
Local Ischemia

1276: Lower Urinary Tract Symptoms: Local Ischemia Assessed by Sonographic Findings and Correlated to Impaired Quality of Life

2006 ◽  
Vol 175 (4S) ◽  
pp. 410-411
Author(s):  
Germar M. Pinggera ◽  
Michael Mitterberger ◽  
Leo Pallwein ◽  
Peter Rehder ◽  
Ferdinand Frauscher ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Local Ischemia ◽  
Urinary Tract Symptoms ◽  
Impaired Quality ◽  
Lower Urinary

Anticoagulants Produced by Thrombin from Fibrin, the Effect on Blood Coagulation, Some Physical Characteristics

1971 ◽  
Vol 26 (02) ◽  
pp. 211-223 ◽  
Author(s):  
Ch R. Muirhead ◽  
D. C Triantaphyllopoulos
Keyword(s):  
Blood Coagulation ◽  
Gel Filtration ◽  
Deae Cellulose ◽  
Fibrin Clot ◽  
Disc Electrophoresis ◽  
Physical Characteristics ◽  
Advanced Stage ◽  
Kallikrein Inhibitor ◽  
Shed Blood ◽  
Complete Lysis

SummaryChromatographed thrombin in the presence of both 50 Kallikrein inhibitor units of Trasylol per ml and 0.1 M E-ACA solubilized fibrin and the products of lysis possessed anticoagulant properties. The peak of the antithrombic activity coincided with the time of complete lysis of the fibrin clot, plasmin lysed fibrin exhibited the peak of its antithrombic activity much earlier. The effect of thrombin lysed fibrin on the prothrombin consumption of shed blood was found to be inhibitory.The products of the digestion of fibrin by thrombin and by plasmin, isolated at an advanced stage of proteolysis were compared by gel filtration, disc electrophoresis and DEAE cellulose chromatography. Differences in physical characteristics of these fibrin breakdown products offer evidence that they were produced by two different enzymes.

Inhibition of Fibrinolysis and Fibrinogenolysis in Man: Comparison of ε-Aminocaproic Acid and Kallikrein Inhibitor

1963 ◽  
Vol 10 (01) ◽  
pp. 106-119 ◽  
Author(s):  
E Beck ◽  
R Schmutzler ◽  
F Duckert ◽  
Keyword(s):  
Aminocaproic Acid ◽  
Side Reactions ◽  
In Vitro Tests ◽  
Factor V ◽  
Clinical Use ◽  
Strong Inhibitor ◽  
Kallikrein Inhibitor ◽  
Therapeutic Possibilities

SummaryInhibitor of kallikrein and trypsin (KI) extracted from bovine parotis was compared with ε-aminocaproic acid (EACA): both substances inhibit fibrinolysis induced with streptokinase. EACA is a strong inhibitor of fibrinolysis in concentrations higher than 0, 1 mg per ml plasma. The same amount and higher concentrations are not able to inhibit completely the proteolytic-side reactions of fibrinolysis (fibrinogenolysis, diminution of factor V, rise of fibrin-polymerization-inhibitors). KI inhibits well proteolysis of plasma components in concentrations higher than 2,5 units per ml plasma. Much higher amounts of KI are needed to inhibit fibrinolysis as demonstrated by our in vivo and in vitro tests.Combination of the two substances for clinical use is suggested. Therapeutic possibilities are discussed.

ENHANCERS OF LIVER REGENERATION IN ONCOLOGICAL SURGERY

2021 ◽  
Vol 108 (Supplement_3) ◽  
Author(s):  
M Osorio Capitan ◽  
S Rose ◽  
I Novo Sukia ◽  
B Herrero de la Parte ◽  
I Ruiz Montesinos ◽  
...  
Keyword(s):  
Folic Acid ◽  
Liver Function ◽  
Liver Regeneration ◽  
Control Group ◽  
Depressant Effect ◽  
Oncological Surgery ◽  
Portal Branch ◽  
Treatment Control ◽  
Early Application ◽  
Mean Size

Abstract INTRODUCTION Chemotherapy hinders liver function and probably its regenerating capacity, forcing to delay it after surgery. Our objective has been to verify this effect in an experimental model and to see if a hepatotrophic agent can prevent it. MATERIAL AND METHODS Four groups of 6 WAG/RijHsd rats (males, 3-4 months) were submitted to ligation of the portal branch to the left lateral and left paramedian lobes. They were sacrificed 36 h later to quantify the percentage of liver corresponding to the ligated lobes (weight), the number of hepatocyte’s nuclei (nº/100 µm2) and their mean size (µm2). One group received no treatment (control); another folic acid (2.5 mg/kg ip, during surgery); other 5-Fluorouracil (5-FU 50 mg/kg ip 48 h before); and the fourth received folic&5-FU. RESULTS The animals treated with folic acid showed a greater number of hepatocyte’s nuclei (24.4 ± 2.77 vs 15.2 ± 1.51) and their mean size was also greater (121 ± 2.34 vs 111 ± 1.8). However, the reduction in weight of the ligated parenchyma was less than in control group (33.4 ± 1.08 vs 29.5 ± 1.08). 5-FU did not modify the number of nuclei (15.6 ± 18.4), although they were smaller in size (104 ± 1.7). The addition of folic acid to 5-FU increased the number of nuclei (21.7 ± 2.8) and normalized their size (111 ± 3.2). CONCLUSIONS 5-FU exerts a depressant effect on livers regeneration, and folic acid overcomes it. Thus, folic acid could allow early application of chemotherapy without affecting liver regeneration.

Increased sensitivity of frog skeletal muscle to procaine in the presence of organic anions

1978 ◽  
Vol 56 (5) ◽  
pp. 739-746 ◽  
Author(s):  
J. G. Foulks ◽  
F. A. Perry
Keyword(s):  
Action Potentials ◽  
Time Course ◽  
Organic Anion ◽  
Organic Anions ◽  
Depressant Effect ◽  
Alkyl Sulfonates ◽  
Carboxylate Anions ◽  
Increased Sensitivity ◽  
Local Anaesthetic Action ◽  
Anaesthetic Action

In solutions containing an organic anion in place of chloride, frog toe muscles displayed increased sensitivity to the local anaesthetic action of procaine. Twitch inhibition by procaine in all media was accompanied by suppression of action potentials without change in membrane resting potentials. The twitch depressant effect of procaine was greater in solutions with carboxylate anions than with alkyl sulfonates. The intensity and the rapidity of onset of the effects of organic anions was related to the size of their hydrophobic component.Procaine accentuated acetate-induced reductions in the [K]0 required to produce K contractures and in the time course of submaximum K contractures. These effects were not shared by benzocaine. They were antagonized by increased [Ca]0.The results indicate that separate agents can exert mutually enhancing actions from opposite surfaces of the sarcolemma to facilitate the inactivation of depolarization-induced excitation–contraction coupling as well as that of the potential-dependent sodium channel.

Some effects of superior laryngeal nerve stimulation on sympathetic preganglionic neuron firing

1979 ◽  
Vol 57 (10) ◽  
pp. 1073-1081 ◽  
Author(s):  
Urs Gerber ◽  
Canio Polosa
Keyword(s):  
Firing Pattern ◽  
Superior Laryngeal Nerve ◽  
Inhibitory Effect ◽  
Laryngeal Nerve ◽  
Depressant Effect ◽  
Excitatory Effect ◽  
Sympathetic Preganglionic Neurons ◽  
Preganglionic Neurons ◽  
Phrenic Motoneurons ◽  
Frequency Of Stimulation

Repetitive electrical stimulation of afferent fibers in the superior laryngeal nerve (SLN) evoked depressant or excitatory effects on sympathetic preganglionic neurons of the cervical trunk in Nembutal-anesthetized, paralyzed, artificially ventilated cats. The depressant effect, which consisted of suppression of the inspiration-synchronous discharge of units with such firing pattern, was obtained at low strength and frequency of stimulation (e.g. 600 mV, 30 Hz) and was absent at end-tidal CO2 values below threshold for phrenic nerve activity. The excitatory effect required higher intensity and frequency of stimulation and was CO2 independent. The depressant effect on sympathetic preganglionic neurons with inspiratory firing pattern seemed a replica of the inspiration-inhibitory effect observed on phrenic motoneurons. Hence, it could be attributed to the known inhibition by the SLN of central inspiratory activity, if it is assumed that this is a common driver for phrenic motoneurons and some sympathetic preganglionic neurons. The excitatory effect, on the other hand, appears to be due to connections of SLN afferents with sympathetic preganglionic neurons, independent of the respiratory center.

scholarly journals A Depressant Effect of Adrenaline on the Rat Diaphragm

Nature ◽  
1951 ◽  
Vol 167 (4251) ◽  
pp. 653-653 ◽  
Author(s):  
K. A. MONTAGU
Keyword(s):  
Rat Diaphragm ◽  
Depressant Effect
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