Cerebral Blood Volume and Hemoglobin Oxygen Saturation Monitoring in Neonatal Brain by near IR Spectroscopy

1986 ◽  
pp. 203-211 ◽  
Author(s):  
Marco Ferrari ◽  
Chiara De Marchis ◽  
Ivo Giannini ◽  
Anna Di Nicola ◽  
Rocco Agostino ◽  
...  
Keyword(s):  
Ir Spectroscopy ◽  
Oxygen Saturation ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Neonatal Brain ◽  
Hemoglobin Oxygen Saturation ◽  
Near Ir

scholarly journals Increased Cerebral Blood Volume and Oxygen Consumption in Neonatal Brain Injury

2009 ◽  
Vol 29 (10) ◽  
pp. 1704-1713 ◽  
Author(s):  
P Ellen Grant ◽  
Nadege Roche-Labarbe ◽  
Andrea Surova ◽  
George Themelis ◽  
Juliette Selb ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Brain Injury ◽  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Neonatal Brain ◽  
Neonatal Brain Injury ◽  
Brain Injured ◽  
Cerebral Tissue Oxygenation ◽  
Post Hoc

With the increasing interest in treatments for neonatal brain injury, bedside methods for detecting and assessing injury status and evolution are needed. We aimed to determine whether cerebral tissue oxygenation (StO2), cerebral blood volume (CBV), and estimates of relative cerebral oxygen consumption (rCMRO2) determined by bedside frequency-domain near-infrared spectroscopy (FD-NIRS) have the potential to distinguish neonates with brain injury from those with non-brain issues and healthy controls. We recruited 43 neonates ≤15 days old and >33 weeks gestational age (GA): 14 with imaging evidence of brain injury, 29 without suspicion of brain injury (4 unstable, 6 stable, and 19 healthy). A multivariate analysis of variance with Newman–Keuls post hoc comparisons confirmed group similarity for GA and age at measurement. StO2 was significantly higher in brain injured compared with unstable neonates, but not statistically different from stable or healthy neonates. Brain-injured neonates were distinguished from all others by significant increases in CBV and rCMRO2. In conclusion, although NIRS measures of StO2 alone may be insensitive to evolving brain injury, increased CBV and rCMRO2 seem to be useful for detecting neonatal brain injury and suggest increased neuronal activity and metabolism occurs acutely in evolving brain injury.

scholarly journals Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models

2016 ◽  
Vol 37 (6) ◽  
pp. 2270-2282 ◽  
Author(s):  
Ararat Chakhoyan ◽  
Aurélien Corroyer-Dulmont ◽  
Marine M Leblond ◽  
Aurélie Gérault ◽  
Jérôme Toutain ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Volume Blood

The alleviation of hypoxia in glioblastoma with carbogen to improve treatment has met with limited success. Our hypothesis is that the eventual benefits of carbogen depend on the capacity for vasodilation. We examined, with MRI, changes in fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in response to carbogen. The analyses were performed in two xenograft models of glioma (U87 and U251) recognized to have different vascular patterns. Carbogen increased fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in contralateral tissues. In the tumor core and peritumoral regions, changes were dependent on the capacity to vasodilate rather than on resting fractional cerebral blood volume. In the highly vascularised U87 tumor, carbogen induced a greater increase in fractional cerebral blood volume and blood oxygen saturation in comparison to the less vascularized U251 tumor. The blood oxygenation level dependent signal revealed a delayed response in U251 tumors relative to the contralateral tissue. Additionally, we highlight the considerable heterogeneity of fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent within U251 tumor in which multiple compartments co-exist (tumor core, rim and peritumoral regions). Finally, our study underlines the complexity of the flow/metabolism interactions in different models of glioblastoma. These irregularities should be taken into account in order to palliate intratumoral hypoxia in clinical trials.

scholarly journals Quantitative Magnetic Resonance Imaging in Experimental Hypercapnia: Improvement in the Relation between Changes in Brain R2* and the Oxygen Saturation of Venous Blood after Correction for Changes in Cerebral Blood Volume

1999 ◽  
Vol 19 (8) ◽  
pp. 853-862 ◽  
Author(s):  
Weili Lin ◽  
Azim Celik ◽  
Richard P. Paczynski ◽  
Chung Y. Hsu ◽  
William J. Powers
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Oxygen Saturation ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Venous Blood ◽  
Resonance Imaging ◽  
Gradient Echo ◽  
Paramagnetic Contrast Agent ◽  
The Brain

Acute hypercapnia simultaneously induces increases in regional cerebral blood volume (rCBV) and the oxygen saturation of cerebral venous blood (Yv). Changes in both physiologic parameters may influence the changes in R2* (ΔR2*) that can be measured in the brain with gradient echo magnetic resonance imaging. The authors examined the effect of incorporating independent measurements of the change in rCBV (ΔrCBV) on the fidelity of the relation between ΔR2* and ΔYv in the setting of experimental hypercapnia. A two-dimensional T2*-weighted gradient echo sequence was used to measure ΔR2* in the brain parenchyma of anesthetized rats in response to hypercapnia with respect to the control state. In parallel, estimates of rCBV were obtained using a three-dimensional steady-state approach in conjunction with a paramagnetic contrast agent during both control and hypercapnic states so that a ΔrCBV could be calculated. Regional CBV values of 2.96 ± 0.82% and 5.74 ± 1.21% were obtained during the control and hypercapnic states, respectively, and linear relations between rCBV and CO2 tension in both arterial ( r = 0.80) and jugular venous ( r = 0.76) blood samples were obtained. When correlating ΔR2* directly with ΔYv, no clear relation was apparent, but a strong linear relation ( r = 0.76) was observed when correction for ΔrCBV was incorporated into the data analysis. These results are consistent with the current understanding of the mechanisms of blood oxygen level–dependent (BOLD) contrast and underscore the potential importance of taking into account ΔrCBV when quantitative estimates of ΔYv from the “BOLD effect” are intended.

Sign in / Sign up

Export Citation Format

Share Document