Relationship Between the Antioxidant Enzyme DT-Diaphorase and Tumor Response to Mitomycin C Treatment

1988 ◽  
pp. 713-716 ◽  
Author(s):  
Chris A. Pritsos ◽  
Lani L. Pardini ◽  
Andrew J. Elliott ◽  
Ronald S. Pardini
Keyword(s):  
Antioxidant Enzyme ◽  
Mitomycin C ◽  
Tumor Response ◽  
Dt Diaphorase

BIOREDUCTIVE ACTIVATION OF THE ANTITUMOR QUINONE MITOMYCIN C BY DT-DIAPHORASE.

1991 ◽  
pp. 619-623
Author(s):  
David Ross ◽  
David Siegel ◽  
Sherri B. Turnipseed ◽  
James A. Ruth ◽  
Peter C. Preusch ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Dt Diaphorase ◽  
Bioreductive Activation

Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C

1998 ◽  
Vol 42 (2) ◽  
pp. 331-334 ◽  
Author(s):  
Zelanna I Goldberg ◽  
Bernard J Cummings ◽  
William B Chapman ◽  
Henry J Klamut ◽  
Andrew M Rauth
Keyword(s):  
Anal Canal ◽  
Mitomycin C ◽  
Anal Canal Carcinoma ◽  
Dt Diaphorase

Bioreductive activation of mitomycin C by DT-diaphorase

Biochemistry ◽  
1992 ◽  
Vol 31 (34) ◽  
pp. 7879-7885 ◽  
Author(s):  
David Siegel ◽  
Howard Beall ◽  
Claudia Senekowitsch ◽  
Masaji Kasai ◽  
Hitoshi Arai ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Dt Diaphorase ◽  
Bioreductive Activation

Intra-Arterial Injection of Adriamycin/Mitomycin C Lipiodol Suspension in Liver Metastases

1987 ◽  
Vol 28 (3) ◽  
pp. 275-280 ◽  
Author(s):  
H. Kobayashi ◽  
H. Inoue ◽  
J. Shimada ◽  
T. Yano ◽  
T. Maeda ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Liver Metastases ◽  
Contrast Enhancement ◽  
Mitomycin C ◽  
Tumor Size ◽  
Tumor Response ◽  
Hepatic Metastases ◽  
Intravenous Contrast

Intra-arterial injection of a suspension of adriamycin and/or mitomycin C in Lipiodol was performed in 17 patients with hepatic metastases, which at angiography were poorly vascularized. Accumulation of Lipiodol in the tumors was demonstrated at computed tomography (CT) in 15 of 17 patients examined within one week. Follow-up with CT showed that Lipiodol remained in the tumor during the first month in 94 per cent, after 2 months in 31 per cent, and after 3 months in 17 per cent. In the non-tumor part of the liver Lipiodol disappeared earlier, and one month after injection it could no longer be traced on CT. In 8/17 cases (47%) CT, after intra-arterial injection of Lipiodol, gave superior information compared with CT after intravenous contrast enhancement. Tumor response was achieved in 9 of 16 cases. Particularly in metastases originating from cancer of the colon and stomach response was observed with a decrease in tumor size in 8 of 10 patients.

Sign in / Sign up

Export Citation Format

Share Document