The Heat Shock Response: A Model System for the Study of Gene Regulation in Drosophila

1980 ◽  
pp. 41-55
Author(s):  
M. L. Pardue ◽  
M. P. Scott ◽  
R. V. Storti ◽  
J. A. Lengyel
Keyword(s):  
Gene Regulation ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Model System ◽  
Shock Response

The heat shock response: A case study of chromatin dynamics in gene regulation

2013 ◽  
Vol 91 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Sheila S. Teves ◽  
Steven Henikoff
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Control Of Gene Expression ◽  
Pol Ii ◽  
Chromatin Dynamics ◽  
Regulatory Processes ◽  
Shock Response ◽  
Rate Limiting

Recent studies in transcriptional regulation using the Drosophila heat shock response system have elucidated many of the dynamic regulatory processes that govern transcriptional activation and repression. The classic view that the control of gene expression occurs at the point of RNA polymerase II (Pol II) recruitment is now giving way to a more complex outlook of gene regulation. Promoter chromatin dynamics coordinate with transcription factor binding to maintain the promoters of active genes accessible. For a large number of genes, the rate-limiting step in Pol II progression occurs during its initial elongation, where Pol II transcribes 30–50 bp and pauses for further signals. These paused genes have unique genic chromatin architecture and dynamics compared with genes where Pol II recruitment is rate limiting for expression. Further elongation of Pol II along the gene causes nucleosome turnover, a continuous process of eviction and replacement, which suggests a potential mechanism for Pol II transit along a nucleosomal template. In this review, we highlight recent insights into transcription regulation of the heat shock response and discuss how the dynamic regulatory processes involved at each transcriptional stage help to generate faithful yet highly responsive gene expression.

scholarly journals Analysis of HSF4 Binding Regions Reveals Its Necessity for Gene Regulation during Development and Heat Shock Response in Mouse Lenses

2008 ◽  
Vol 283 (44) ◽  
pp. 29961-29970 ◽  
Author(s):  
Mitsuaki Fujimoto ◽  
Koji Oshima ◽  
Toyohide Shinkawa ◽  
Bei Bei Wang ◽  
Sachiye Inouye ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Shock Response ◽  
Binding Regions
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